Publikationer pr. år
Publikationer pr. år
Rasmus Skov Husted, Carsten Juhl, Anders Troelsen, Kristian Thorborg, Thomas Kallemose, Michael Skovdal Rathleff, Thomas Bandholm
Publikation: Bidrag til tidsskrift › Review (oversigtsartikel) › peer review
OBJECTIVE: The aim of this systematic review was to evaluate the relationship between prescribed knee-extensor strength exercise dosage in pre-operative exercise intervention and the effect on knee-extensor muscle strength prior to and following TKA. Additional meta-analyses report the effect of pre-habilitation on outcomes prior to and following TKA.
DESIGN: A systematic literature search was performed including RCT´s evaluating the effect of pre-operative exercise prior to and following TKA. Meta-regression analysis was performed to evaluate the dose-response relationship between prescribed exercise dose and the pooled effect, measured as standardized mean difference (SMD). The prescribed exercise dose was quantified using a formula accounting for as many exercise descriptors as possible. Risk of bias in the included trials was assessed using the Cochrane Risk of Bias Tool.
RESULTS: Twelve trials with 616 patients were included. Meta-regression analysis showed no relationship between prescribed pre-operative knee-extensor exercise dosage and change in knee-extensor strength neither prior to (slope 0.0005 [95%CI -0.007 to 0.008]) or three months following TKA (slope 0.0014 [95%CI -0.006 to 0.009]). Prior to TKA, a moderate effect favoring pre-operative exercise for increase in knee-extensor strength was found (SMD 0.50 [95%CI 0.12 to 0.88]), but not at three months following TKA (SMD -0.01 [95%CI -0.45 to 0.43]). Risk of bias was generally assessed as unclear.
CONCLUSION: Meta-regression analysis of existing trials suggests no relationship between the prescribed pre-operative knee-extensor exercise dosage and the change in knee-extensor strength observed prior to and following TKA. Pre-operative exercise including knee-extensor muscle strength exercise increased knee-extensor strength moderately prior to but not three months following TKA.
PROTOCOL REGISTRATION: PROSPERO ID (CRD42018076308) (http://www.crd.york.ac.uk/PROSPERO/).
Originalsprog | Engelsk |
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Tidsskrift | Osteoarthritis and Cartilage |
Vol/bind | 28 |
Udgave nummer | 11 |
Sider (fra-til) | 1412-1426 |
Antal sider | 15 |
ISSN | 1063-4584 |
DOI | |
Status | Udgivet - nov. 2020 |
Publikation: Konferencebidrag uden forlag/tidsskrift › Konferenceabstrakt til konference › Forskning › peer review
Publikation: Konferencebidrag uden forlag/tidsskrift › Konferenceabstrakt til konference › Forskning › peer review