TY - JOUR
T1 - The validity of pathology codes for biopsy-confirmed kidney disease in the Danish National Patobank
AU - Møller, Marie
AU - Bressendorff, Iain
AU - Borg, Rikke
AU - Dieperink, Hans
AU - Gregersen, Jon W.
AU - Hansen, Helle
AU - Hommel, Kristine
AU - Hornum, Mads
AU - Ivarsen, Per
AU - Jensen, Karina H.
AU - Jørgensen, Morten B.
AU - Kristensen, Tilde
AU - Krustrup, Dorrit
AU - Mose, Frank H.
AU - Rossing, Peter
AU - Otte, Kjeld E.
AU - Persson, Frederik
AU - Schandorff, Kristine D.
AU - Hansen, Ditte
N1 - © The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.
PY - 2024/8
Y1 - 2024/8
N2 - BACKGROUND: This study validates the application of Systematized Nomenclature of Medicine second edition (SNOMED II) codes used to describe medical kidney biopsies in Denmark in encoded form, aiming to support robust epidemiological research on the causes, treatments and prognosis of kidney diseases.METHODS: Kidney biopsy reports from 1 January 1998 to 31 December 2018 were randomly extracted from the Danish National Patobank, using SNOMED codes. A 5% sample was selected, and nephrologists assessed the corresponding medical records, assigning each case the applied clinical diagnoses. Sensitivity, specificity, positive predictive values (PPV), negative predictive values and Cohen's kappa coefficient for the retrieved SNOMED codes were calculated.RESULTS: A total of 613 kidney biopsies were included. The primary clinical disease groups were glomerular disease (n = 368), tubulointerstitial disease (n = 67), renal vascular disease (n = 51), diabetic nephropathy (n = 51) and various renal disorders (n = 40). Several SNOMED codes were used to describe each clinical disease group and PPV for the combined SNOMED codes were high for glomerular disease (94%), diabetic nephropathy (85%) and systemic diseases affecting the kidney (96%). Conversely, tubulointerstitial disease (62%), renal vascular disease (60%) and other renal disorders (17%) showed lower PPV.CONCLUSIONS: SNOMED codes have a high PPV for glomerular diseases, diabetic nephropathy and systemic diseases affecting the kidney, in which they could be applied for future epidemiological research.
AB - BACKGROUND: This study validates the application of Systematized Nomenclature of Medicine second edition (SNOMED II) codes used to describe medical kidney biopsies in Denmark in encoded form, aiming to support robust epidemiological research on the causes, treatments and prognosis of kidney diseases.METHODS: Kidney biopsy reports from 1 January 1998 to 31 December 2018 were randomly extracted from the Danish National Patobank, using SNOMED codes. A 5% sample was selected, and nephrologists assessed the corresponding medical records, assigning each case the applied clinical diagnoses. Sensitivity, specificity, positive predictive values (PPV), negative predictive values and Cohen's kappa coefficient for the retrieved SNOMED codes were calculated.RESULTS: A total of 613 kidney biopsies were included. The primary clinical disease groups were glomerular disease (n = 368), tubulointerstitial disease (n = 67), renal vascular disease (n = 51), diabetic nephropathy (n = 51) and various renal disorders (n = 40). Several SNOMED codes were used to describe each clinical disease group and PPV for the combined SNOMED codes were high for glomerular disease (94%), diabetic nephropathy (85%) and systemic diseases affecting the kidney (96%). Conversely, tubulointerstitial disease (62%), renal vascular disease (60%) and other renal disorders (17%) showed lower PPV.CONCLUSIONS: SNOMED codes have a high PPV for glomerular diseases, diabetic nephropathy and systemic diseases affecting the kidney, in which they could be applied for future epidemiological research.
KW - Danish National Patient Registry
KW - SNOMED codes
KW - kidney biopsy
KW - nephrology
KW - validation
UR - http://www.scopus.com/inward/record.url?scp=85201060710&partnerID=8YFLogxK
U2 - 10.1093/ckj/sfae203
DO - 10.1093/ckj/sfae203
M3 - Journal article
C2 - 39131077
SN - 2048-8505
VL - 17
JO - Clinical Kidney Journal
JF - Clinical Kidney Journal
IS - 8
M1 - sfae203
ER -