Abstract
Hyponatremia, a condition of low serum concentrations of sodium, shares an
intertwined and often paradoxical relationship with thiazide diuretics and
osteoporosis. In retrospective studies, thiazides have been shown to protect against osteoporosis-related fractures, but also to cause hyponatremia which is associated with a higher risk of falling. In recent years, evidence has been found of an association between hyponatremia and osteoporosis in epidemiological and basal in vitro studies. Further research is needed to determine three aspects; who will benefit from thiazides in terms of fracture risk, why this is the case, and who are running an unnecessary risk of thiazide-induced hyponatremia when commencing therapy, predisposing to fractures.
The aim of this thesis was to investigate the role of hyponatremia in Danish
osteoporosis patients, to investigate possible age groups that may benefit from
thiazide therapy on fracture risk, and to examine the effect of hyponatremia on
mortality, hospitalization burden and readmission risk.
This thesis is based on six retrospective epidemiological studies using Danish and Belgian data of regional and national origins, and one systematic review and metaanalysis reviewing clinical trials of thiazide use on bone mineral density and
electrolyte metabolism.
intertwined and often paradoxical relationship with thiazide diuretics and
osteoporosis. In retrospective studies, thiazides have been shown to protect against osteoporosis-related fractures, but also to cause hyponatremia which is associated with a higher risk of falling. In recent years, evidence has been found of an association between hyponatremia and osteoporosis in epidemiological and basal in vitro studies. Further research is needed to determine three aspects; who will benefit from thiazides in terms of fracture risk, why this is the case, and who are running an unnecessary risk of thiazide-induced hyponatremia when commencing therapy, predisposing to fractures.
The aim of this thesis was to investigate the role of hyponatremia in Danish
osteoporosis patients, to investigate possible age groups that may benefit from
thiazide therapy on fracture risk, and to examine the effect of hyponatremia on
mortality, hospitalization burden and readmission risk.
This thesis is based on six retrospective epidemiological studies using Danish and Belgian data of regional and national origins, and one systematic review and metaanalysis reviewing clinical trials of thiazide use on bone mineral density and
electrolyte metabolism.
| Bidragets oversatte titel | Thiazid-diuretika og hyponatriæmi i relation til osteoporose |
|---|---|
| Originalsprog | Engelsk |
| Vejledere |
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| Udgiver | |
| ISBN'er, elektronisk | 978-87-7210-068-5 |
| DOI | |
| Status | Udgivet - 2017 |
Bibliografisk note
PhD supervisor:Professor Peter Vestergaard, Aalborg University, Denmark
Assistant PhD supervisor:
Associate Professor, MD, PhD Pia Eiken, University of Copenhagen, Denmark
Emneord
- Thiazid
- Hyponatriæmi
- Fraktur
- Osteoporose
- Knoglebrud
- Saltbalance
- Vanddrivende