Transfusion of blood during cardiac surgery is associated with higher long-term mortality in low-risk patients

Carl-Johan Jakobsen, Pia Katarina Ryhammer, Mariann Tang Jensen, Jan Jesper Andreasen, Poul Erik Mortensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

93 Citationer (Scopus)

Abstract

OBJECTIVENumerous reports have emphasized the need for reduction in transfusions of allogeneic red blood cells (RBC) due to increased morbidity and mortality. Nevertheless, transfusion rates are still high in several cardiac surgery institutions. Reports on long-term survival after cardiac surgery and RBC transfusion are few.METHODSData from the Western Denmark Heart Registry (WDHR) were used to identify all (25 117) adult cardiac surgery performed in four centres during 1999-2010. Patients with multiple entries (1049), re-do cardiac surgery (985), special/complex procedures (2329), dying within 30 days (668) and not eligible for follow-up (85) were excluded leaving a cohort of 20 001. Registration in the WDHR is mandatory. WDHR and the unique Danish Civil Registration System with continuous sequential updates of the Danish population ensure that all patients and outcomes are accounted for.RESULTSKaplan-Meier survival plot for low-risk patients (EuroSCORE 0-4), undergoing simple cardiac surgery showed a significantly lower estimated survival after >4500 days (0.637 vs. 0.745) when receiving perioperative RBC transfusion (P 
OriginalsprogEngelsk
TidsskriftEuropean Journal of Cardio-Thoracic Surgery
Vol/bind42
Sider (fra-til)114-20
Antal sider7
ISSN1010-7940
DOI
StatusUdgivet - 2012
Udgivet eksterntJa

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