Abstract
Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy.
Bidragets oversatte titel | Combination therapy of thyroxine and triiodothyronine in hypothyroid patients |
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Originalsprog | Dansk |
Artikelnummer | V05180340 |
Tidsskrift | Ugeskrift for Laeger |
Vol/bind | 180 |
Udgave nummer | 20A |
Sider (fra-til) | 1843-1846 |
Antal sider | 4 |
ISSN | 0041-5782 |
Status | Udgivet - 2018 |