Type 1 diabetes is associated with T-wave morphology changes: The Thousand & 1 Study

Jonas Lynggaard Isaksen, Claus Graff, Christina Ellervik, Jan Skov Jensen, Henrik Ullits Andersen, Peter Rossing, Jørgen K. Kanters, Magnus T. Jensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

1 Citationer (Scopus)
56 Downloads (Pure)

Abstrakt

Background: Repolarization is impaired in patients with type 1 diabetes mellitus (T1DM), and repolarization disturbances are associated with an increased mortality. To study cardiac repolarization, we assessed T-wave morphology in patients with T1DM without known heart disease. Methods: 855 T1DM patients without known heart disease were matched 1:2 with 1710 people from a background population. Rate-corrected T-wave morphology markers were obtained. Patients were stratified by albuminuria. Results are mean ± standard deviation. Results: T-waves were flatter (0.398 ± 0.059 vs. 0.382 ± 0.062, p < 0.001) and more asymmetric (0.082 ± 0.068 vs. 0.071 ± 0.084, p = 0.001) in T1DM. Patients with albuminuria had an increased heart rate (normoalbuminuria: 71 ± 13 bpm, microalbuminuria: 75 ± 12 bpm, p < 0.001, macroalbuminuria: 78 ± 12 bpm, p < 0.001) and more asymmetric T-waves (normoalbuminuria: 0.079 ± 0.060, microalbuminuria: 0.094 ± 0.085, p < 0.01, macroalbuminuria: 0.101 ± 0.080, p < 0.01), but the QTc interval remained unchanged. Conclusions: T1DM is associated with changes in T-wave morphology. T-wave asymmetry but not QTc interval is associated with albuminuria in T1DM and may be used for stratification.

OriginalsprogEngelsk
TidsskriftJournal of Electrocardiology
Vol/bind51
Udgave nummer6, Suppl.
Sider (fra-til)S72-S77
ISSN0022-0736
DOI
StatusUdgivet - 1 nov. 2018

Fingeraftryk Dyk ned i forskningsemnerne om 'Type 1 diabetes is associated with T-wave morphology changes: The Thousand & 1 Study'. Sammen danner de et unikt fingeraftryk.

  • Projekter

    • 1 Igangværende

    Cardiac Repolarization

    Graff, C.

    01/08/2005 → …

    Projekter: ProjektForskning

    Citationsformater

    Isaksen, J. L., Graff, C., Ellervik, C., Jensen, J. S., Andersen, H. U., Rossing, P., Kanters, J. K., & Jensen, M. T. (2018). Type 1 diabetes is associated with T-wave morphology changes: The Thousand & 1 Study. Journal of Electrocardiology, 51(6, Suppl.), S72-S77. https://doi.org/10.1016/j.jelectrocard.2018.05.015