Use of Pregabalin - A Nationwide Pharmacoepidemiological Drug Utilization Study with Focus on Abuse Potential

O Schjerning, A Pottegård, P Damkier, M Rosenzweig, Jimmi Nielsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

47 Citationer (Scopus)

Abstract

Introduction: Pregabalin is currently approved for the treatment of epilepsy, generalized anxiety disorder and neuropathic pain with a licensed dosage range of 150 mg to 600 mg/day. Growing concern about the abuse potential of pregabalin is partly based on reports of pregabalin being used in dosages that exceed the approved therapeutic range. Methods: To identify predictors of pregabalin use above recommended dosage, we conducted a pharmacoepidemological drug utilization study using the Danish nationwide registers. We deployed 4 measures of abuse: high use (≥600 mg/day) or very high use (≥1 200 mg/day) over a 6- or 12-month period, respectively. Multiple logistic regression was used to identify patient and treatment characteristics that were associated with either abuse marker. Results: Out of 42 520 pregabalin users 4 090 (9.6%) were treated with more than 600 mg/day for 6 months and 2 765 (6.5%) for more than 12 months. Male gender and prescription of antipsychotics and benzodiazepines were associated with increased risk of use of above the recommended dosage. Discussion: Use of pregabalin above recommended dosages was rare but abuse may occur in susceptible patients.

OriginalsprogEngelsk
TidsskriftPharmacopsychiatry
Vol/bind49
Udgave nummer4
Sider (fra-til)155-161
Antal sider7
ISSN0176-3679
DOI
StatusUdgivet - 2016

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