TY - JOUR
T1 - Validation study of the early onset schizophrenia diagnosis in the Danish Psychiatric Central Research Register
AU - Vernal, Ditte Lammers
AU - Stenstrøm, Anne Dorte
AU - Staal, Nina
AU - Christensen, Anne Marie Raabjerg
AU - Ebbesen, Christine
AU - Pagsberg, Anne Katrine
AU - Correll, Christoph U.
AU - Nielsen, René Ernst
AU - Lauritsen, Marlene Briciet
PY - 2018
Y1 - 2018
N2 - The objective of this study is to assess (1) the concordance and validity of schizophrenia register diagnoses among children and adolescents (early onset schizophrenia = EOS) in the Danish Psychiatric Central Research Register (DPCRR), and (2) the validity of clinical record schizophrenia diagnoses. Psychiatric records from 200 patients with a first-time diagnosis of schizophrenia (F20.x) at age 0.78–0.83 depending on classification. Compared to diagnoses made in outpatient settings, EOS diagnoses during hospitalizations were more likely to be valid and had fewer registration errors. Diagnosed in inpatient settings, EOS diagnoses are reliable and valid for register-based research. Schizophrenia diagnosed in children and adolescents in outpatient settings were found to have a high number of false-positives, both due to registration errors and diagnostic practice. Utilizing this knowledge, it is possible to reduce the number of false-positives in register-based research of EOS.
AB - The objective of this study is to assess (1) the concordance and validity of schizophrenia register diagnoses among children and adolescents (early onset schizophrenia = EOS) in the Danish Psychiatric Central Research Register (DPCRR), and (2) the validity of clinical record schizophrenia diagnoses. Psychiatric records from 200 patients with a first-time diagnosis of schizophrenia (F20.x) at age 0.78–0.83 depending on classification. Compared to diagnoses made in outpatient settings, EOS diagnoses during hospitalizations were more likely to be valid and had fewer registration errors. Diagnosed in inpatient settings, EOS diagnoses are reliable and valid for register-based research. Schizophrenia diagnosed in children and adolescents in outpatient settings were found to have a high number of false-positives, both due to registration errors and diagnostic practice. Utilizing this knowledge, it is possible to reduce the number of false-positives in register-based research of EOS.
KW - Early onset schizophrenia
KW - Register
KW - Schizophrenia
KW - Validity
UR - http://www.scopus.com/inward/record.url?scp=85040014394&partnerID=8YFLogxK
U2 - 10.1007/s00787-017-1102-z
DO - 10.1007/s00787-017-1102-z
M3 - Journal article
SN - 1435-165X
VL - 27
SP - 965
EP - 975
JO - European Child & Adolescent Psychiatry
JF - European Child & Adolescent Psychiatry
IS - 8
ER -