TY - JOUR
T1 - Venous thrombosis in pancreaticobiliary tract cancer
T2 - outcome and prognostic factors
AU - Larsen, Anders Christian
AU - Brøndum Frøkjaer, Jens
AU - Iyer, Victor Vishwanath
AU - Vincents Fisker, Rune
AU - Sall, Mogens
AU - Yilmaz, Mette Karen
AU - Møller, Bjarne Kuno
AU - Kristensen, Søren Risom
AU - Thorlacius-Ussing, Ole
N1 - This article is protected by copyright. All rights reserved.
PY - 2015/1/16
Y1 - 2015/1/16
N2 - BACKGROUND: Differences in outcome among cancer patients with incidental versus symptomatic venous thromboembolism (VTE) are unknown. In this study, Patients with extrahepatic pancreatico-biliary tract cancer (PBC) were selected for a prospective cohort study between February 2008 and February 2011.METHOD: At the time of cancer diagnosis, all patients were examined for deep vein thrombosis (DVT) using bilateral compression ultrasonography (biCUS). Computed tomography pulmonary angiography (CTPA) was also performed to diagnose pulmonary embolisms (PEs). After inclusion, the patients were followed up with clinical examinations, blood collections and biCUS.RESULTS: A total of 121 PBC patients were enrolled. At the time of cancer diagnosis, 15 patients had experienced a VTE (12.4%, 95% confidence interval (CI), 7.1-19.6), including six symptomatic and nine incidental cases. A total of 25 first-time VTE events were identified (20.7%, CI, 13.8 - 29.0), Patients with a VTE had reduced survival, with a median survival time (mOS) of 4.4 months (95% CI, 2.2-11.5; HR). The median OS of the patients with incidental VTE was 3.0 months (95% CI, 0.1-15.0), which was not different from the median OS of the patients with symptomatic VTE (5.0 months; 95% CI, 2.1 - 14.5). The median overall survival (OS) was 11.9 (95% CI, 8.1-14.7) months in the PBC patients with no VTEs.CONCLUSION: The occurrence of a VTE event in a PBC patient within the first months of the disease is associated with significantly increased mortality. This article is protected by copyright. All rights reserved.
AB - BACKGROUND: Differences in outcome among cancer patients with incidental versus symptomatic venous thromboembolism (VTE) are unknown. In this study, Patients with extrahepatic pancreatico-biliary tract cancer (PBC) were selected for a prospective cohort study between February 2008 and February 2011.METHOD: At the time of cancer diagnosis, all patients were examined for deep vein thrombosis (DVT) using bilateral compression ultrasonography (biCUS). Computed tomography pulmonary angiography (CTPA) was also performed to diagnose pulmonary embolisms (PEs). After inclusion, the patients were followed up with clinical examinations, blood collections and biCUS.RESULTS: A total of 121 PBC patients were enrolled. At the time of cancer diagnosis, 15 patients had experienced a VTE (12.4%, 95% confidence interval (CI), 7.1-19.6), including six symptomatic and nine incidental cases. A total of 25 first-time VTE events were identified (20.7%, CI, 13.8 - 29.0), Patients with a VTE had reduced survival, with a median survival time (mOS) of 4.4 months (95% CI, 2.2-11.5; HR). The median OS of the patients with incidental VTE was 3.0 months (95% CI, 0.1-15.0), which was not different from the median OS of the patients with symptomatic VTE (5.0 months; 95% CI, 2.1 - 14.5). The median overall survival (OS) was 11.9 (95% CI, 8.1-14.7) months in the PBC patients with no VTEs.CONCLUSION: The occurrence of a VTE event in a PBC patient within the first months of the disease is associated with significantly increased mortality. This article is protected by copyright. All rights reserved.
U2 - 10.1111/jth.12843
DO - 10.1111/jth.12843
M3 - Journal article
C2 - 25594256
SN - 1538-7933
VL - 13
SP - 555
EP - 562
JO - Journal of Thrombosis and Haemostasis
JF - Journal of Thrombosis and Haemostasis
IS - 4
ER -