Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Hina Kalra; Richard J Simpson; Hong Ji; Elena Aikawa; Peter Altevogt; Philip Askenase; Vincent C Bond; Francesc E Borràs; Xandra Breakefield; Vivian Budnik; Edit Buzas; Giovanni Camussi; Aled Clayton; Emanuele Cocucci; Juan M Falcon-Perez; Susanne Gabrielsson; Yong Song Gho; Dwijendra Gupta; H C Harsha; An Hendrix; Andrew F Hill; Jameel M Inal; Guido Jenster; Eva-Maria Krämer-Albers; Sai Kiang Lim; Alicia Llorente; Jan Lötvall; Antonio Marcilla; Lucia Mincheva-Nilsson; Irina Nazarenko; Rienk Nieuwland; Esther N M Nolte-'t Hoen; Akhilesh Pandey; Tushar Patel; Melissa G Piper; Stefano Pluchino; T S Keshava Prasad; Lawrence Rajendran; Graca Raposo; Michel Record; Gavin E Reid; Francisco Sánchez-Madrid; Raymond M Schiffelers; Pia Siljander; Allan Stensballe; Willem Stoorvogel; Douglas Taylor; Clotilde Thery; Hadi Valadi; Bas W M van Balkom; Jesús Vázquez; Michel Vidal; Marca H M Wauben; María Yáñez-Mó; Margot Zoeller; Suresh Mathivanan

doi:10.1371/journal.pbio.1001450

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Hina Kalra, Richard J Simpson, Hong Ji, Elena Aikawa, Peter Altevogt, Philip Askenase, Vincent C Bond, Francesc E Borràs, Xandra Breakefield, Vivian Budnik, Edit Buzas, Giovanni Camussi, Aled Clayton, Emanuele Cocucci, Juan M Falcon-Perez, Susanne Gabrielsson, Yong Song Gho, Dwijendra Gupta, H C Harsha, An HendrixAndrew F Hill, Jameel M Inal, Guido Jenster, Eva-Maria Krämer-Albers, Sai Kiang Lim, Alicia Llorente, Jan Lötvall, Antonio Marcilla, Lucia Mincheva-Nilsson, Irina Nazarenko, Rienk Nieuwland, Esther N M Nolte-'t Hoen, Akhilesh Pandey, Tushar Patel, Melissa G Piper, Stefano Pluchino, T S Keshava Prasad, Lawrence Rajendran, Graca Raposo, Michel Record, Gavin E Reid, Francisco Sánchez-Madrid, Raymond M Schiffelers, Pia Siljander, Allan Stensballe, Willem Stoorvogel, Douglas Taylor, Clotilde Thery, Hadi Valadi, Bas W M van Balkom, Jesús Vázquez, Michel Vidal, Marca H M Wauben, María Yáñez-Mó, Margot Zoeller, Suresh Mathivanan

Institut for Kemi og Biovidenskab

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

975 Citationer (Scopus)

Abstract

Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.

Originalsprog	Engelsk
Tidsskrift	PLoS - Biology
Vol/bind	10
Udgave nummer	12
ISSN	1544-9173
DOI	https://doi.org/10.1371/journal.pbio.1001450
Status	Udgivet - 2012

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Kalra, H., Simpson, R. J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., Bond, V. C., Borràs, F. E., Breakefield, X., Budnik, V., Buzas, E., Camussi, G., Clayton, A., Cocucci, E., Falcon-Perez, J. M., Gabrielsson, S., Gho, Y. S., Gupta, D., Harsha, H. C., ... Mathivanan, S. (2012). Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation. PLoS - Biology, 10(12). https://doi.org/10.1371/journal.pbio.1001450

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abstract = "Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.",

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AU - Kalra, Hina

AU - Simpson, Richard J

AU - Ji, Hong

AU - Aikawa, Elena

AU - Altevogt, Peter

AU - Askenase, Philip

AU - Bond, Vincent C

AU - Borràs, Francesc E

AU - Breakefield, Xandra

AU - Budnik, Vivian

AU - Buzas, Edit

AU - Camussi, Giovanni

AU - Clayton, Aled

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AU - Gho, Yong Song

AU - Gupta, Dwijendra

AU - Harsha, H C

AU - Hendrix, An

AU - Hill, Andrew F

AU - Inal, Jameel M

AU - Jenster, Guido

AU - Krämer-Albers, Eva-Maria

AU - Lim, Sai Kiang

AU - Llorente, Alicia

AU - Lötvall, Jan

AU - Marcilla, Antonio

AU - Mincheva-Nilsson, Lucia

AU - Nazarenko, Irina

AU - Nieuwland, Rienk

AU - Nolte-'t Hoen, Esther N M

AU - Pandey, Akhilesh

AU - Patel, Tushar

AU - Piper, Melissa G

AU - Pluchino, Stefano

AU - Prasad, T S Keshava

AU - Rajendran, Lawrence

AU - Raposo, Graca

AU - Record, Michel

AU - Reid, Gavin E

AU - Sánchez-Madrid, Francisco

AU - Schiffelers, Raymond M

AU - Siljander, Pia

AU - Stensballe, Allan

AU - Stoorvogel, Willem

AU - Taylor, Douglas

AU - Thery, Clotilde

AU - Valadi, Hadi

AU - van Balkom, Bas W M

AU - Vázquez, Jesús

AU - Vidal, Michel

AU - Wauben, Marca H M

AU - Yáñez-Mó, María

AU - Zoeller, Margot

AU - Mathivanan, Suresh

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N2 - Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.

AB - Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.

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U2 - 10.1371/journal.pbio.1001450

DO - 10.1371/journal.pbio.1001450

M3 - Journal article

C2 - 23271954

SN - 1544-9173

VL - 10

JO - PLoS - Biology

JF - PLoS - Biology

IS - 12

ER -

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Abstract

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