Description
Autoimmune diseases are caused by an un-controlled immune response where the host’s immune system targets healthy cells and tissue. The etiology of the immune response is incomplete and the diseases are poorly understood, but it is clear that both environmental and genetic factors are involved.In this project, we attempt to gain a deeper understanding of the underlying biological triggers of the autoimmune diseases by using inflammatory joint- and intestine diseases as a model system.
The analytical part of the project is based on strategies for quantitative mass spectrometry (MS) driven proteome analysis, with emphasis on post translational modifications. The differences in proteome between intestinal biopsy samples from patients with inflammatory bowel diseases, including Crohn’s Disease (CD) and Ulcerative Colitis (UC), is analyzed and compared to a healthy control group. A part of the project is dedicated to the analysis of the proteins in synovial fluid in collaboration with Dr Hanno Steens lab at Children’s Hospital Boston Harvard Medical School.
Furthermore, the protein composition of the inflammation inducing protein complexes, the inflammasomes, is investigated when expression is induced by an infection, in order to investigate the inflammation triggering pathway.
The project is a collaboration between Aalborg University, Copenhagen University, South Danish University and Regional Hospitals Silkeborg and Viborg as well as the pharmaceutical company Ferring and Dr Hanno Steen's proteomics laboratory at Children’s Hospital Boston, Harvard Medical School.
| Period | 20 Mar 2013 |
|---|---|
| Held at | Unknown external organisation |