Supplementary Material for: Plasma Phospholipid Long-Chain n-3 Polyunsaturated Fatty Acids and Body Weight Change

  • Marianne U. Jakobsen (Creator)
  • Claus Dethlefsen (Creator)
  • Karen Margrete Due (Creator)
  • Nadia Slimani (Creator)
  • Veronique Chajès (Creator)
  • Anne M May (Creator)
  • Thorkild I. A. Sørensen (Contributor)
  • Jytte Halkjaer (Creator)
  • Anne Tjønneland (Creator)
  • Francoise Clavel-Chapelon (Creator)



Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was –0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: –20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. Conclusion: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.
Date made available1 Aug 2011
PublisherKarger Publishers
  • Plasma Phospholipid Long-Chain n-3 Polyunsaturated Fatty Acids and Body Weight Change

    Jakobsen, M. U., Dethlefsen, C., Due, K. M., Slimani, N., Chajès, V., May, A. M., Sørensen, T. I. A., Halkjær, J., Tjønneland, A., Clavel-Chapelon, F., Boutron-Ruault, M-C., Fagherazzi, G., Teucher, B., Kaaks, R., Boeing, H., Schütze, M., Trichopoulou, A., Zylis, D., Makrygiannis, G., Palli, D., & 21 othersMattiello, A., Tagliabue, G., van der A, D. L., Bueno-de-Mesquita, H. B., Rodríguez, L., Travier, N., Molina-Montes, E., Huerta, J. M., Barricarte, A., Amiano, P., Manjer, J., Wirfält, E., Johansson, I., Hallmans, G., Khaw, K-T., Wareham, N. J., Crowe, F., Romieu, I., Riboli, E., Peeters, P. H. M. & Overvad, K., 1 Jan 2011, In: Obesity Facts. 4, p. 312-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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