Aalborg University Hospital

    Research Output 2000 2020

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    Letter
    2019
    1 Citation (Scopus)

    Clinical prognostic scores are poor predictors of overall survival in various types of malignant lymphomas

    Biccler, J. L., El-Galaly, T. C., Bøgsted, M., Jørgensen, J., de Nully Brown, P., Poulsen, C. B., Starklint, J., Juul, M. B., Christensen, J. H., Josefsson, P., Dessau, A. & Jakobsen, L. H., 2019, In : Leukemia and Lymphoma. 60, 6, p. 1580–1583 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

    3 Citations (Scopus)

    DAHANCA 9 - a randomized multicenter study to compare accelerated normo-fractionated radiotherapy with accelerated hyperfractionated radiotherapy in patients with primary squamous cell carcinoma of the head and neck (HNSCC)

    Evensen, J. F., Sand Hansen, H., Overgaard, M., Johansen, J., Andersen, L. J. & Overgaard, J., 8 Jul 2019, In : Acta oncologica (Stockholm, Sweden). p. 1-4 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

    Dose-response curves for co-exposure inhalation challenges with ozone and pollen allergen

    Ørby, P. V., Bønløkke, J. H., Bibby, B. M., Ravn, P., Hertel, O., Sigsgaard, T. & Schlünssen, V., Aug 2019, In : European Respiratory Journal. 54, 2, 3 p., 1801208.

    Research output: Contribution to journalLetterResearchpeer-review

    1 Citation (Scopus)

    Efficacy and toxicity of eribulin treatment in metastatic breast cancer patients

    Brems-Eskildsen, A. S., Kristoffersen, K. B., Linnet, S., Lörincz, T. & Langkjer, S. T., 2 Jan 2019, In : Acta Oncologica. 58, 1, p. 119-121 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

    1 Citation (Scopus)

    Frequency of bowel perforation and impact of bowel rest in aggressive non-Hodgkin lymphoma with gastrointestinal involvement

    Chin, C. K., Tsang, E., Mediwake, H., Khair, W., Biccler, J., Hapgood, G., Mollee, P., Nizich, Z., Joske, D., Radeski, D., Cull, G., Villa, D., El-Galaly, T. C. & Cheah, C. Y., 2019, In : British Journal of Haematology. 184, 5, p. 826-828 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

    Hemoglobin variants found in relation to HbA1c testing: high occurrence of Hb Athens-Georgia in the Northern Jutland, Denmark

    Nybo, J., Hansen, A. T., Petersen, J. B. & Brock, A., Jun 2019, In : Clinical Chemistry and Laboratory Medicine. 57, 6, p. E108-E110

    Research output: Contribution to journalLetterResearchpeer-review

    Left Ventricular Endocardial Pacing With a Novel Wireless CRT System Pacing Threshold Trend: Medium Term 2-Year Data

    Twomey, D. J., Riahi, S., Turley, A. J. & James, S., 1 May 2019, In : J A C C: Clinical Electrophysiology. 5, 5, p. 635-636 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

    1 Citation (Scopus)

    Long-Term Outcomes of Partial Oral Treatment of Endocarditis

    Bundgaard, H., Ihlemann, N., Gill, S. U., Bruun, N. E., Elming, H., Madsen, T., Jensen, K. T., Fursted, K., Christensen, J. J., Schultz, M., Østergaard, L., Rosenvinge, F., Schønheyder, H. C., Helweg-Larsen, J., Fosbøll, E. L., Køber, L., Torp-Pedersen, C., Tønder, N., Moser, C. & Iversen, K., 4 Apr 2019, In : The New England Journal of Medicine. 380, 14, p. 1373-1374 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

    No differential overall or relative survival effect of rituximab in male and female patients with diffuse large B-cell lymphoma: a Danish population-based study of 3783 patients

    Jakobsen, L. H., Biccler, J. L., Brown, P. D. N., Jørgensen, J. M., Josefsson, P. L., Poulsen, C. B., Starklint, J., Clausen, M. R., Pedersen, P. T., Juul, M. B., Severinsen, M. T., Bøgsted, M. & El-Galaly, T. C., 6 May 2019, In : Leukemia and Lymphoma. 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

    8 Downloads (Pure)
    Open Access
    File
    Preclinical Drug Evaluations
    Attention Deficit Disorder with Hyperactivity
    Immunoassay
    Amphetamine
    Bupropion

    Pilot study experiences with hyperpolarized [1-13 C]pyruvate MRI in pancreatic cancer patients

    Stødkilde-Jørgensen, H., Laustsen, C., Hansen, E. S. S., Schulte, R., Ardenkjaer-Larsen, J. H., Comment, A., Frøkiaer, J., Ringgaard, S., Bertelsen, L. B., Ladekarl, M. & Weber, B., 1 Aug 2019, In : Journal of Magnetic Resonance Imaging.

    Research output: Contribution to journalLetterResearchpeer-review

    Pyruvic Acid
    Pancreatic Neoplasms
    1 Citation (Scopus)

    Subglottic squamous cell carcinoma in Denmark 1971-2015 - a national population-based cohort study from DAHANCA, the Danish Head and Neck Cancer group

    Hill-Madsen, L., Kristensen, C. A., Andersen, E., Johansen, J., Andersen, L. J., Primdahl, H., Overgaard, J. & Lyhne, N. M., 31 Jul 2019, In : Acta oncologica (Stockholm, Sweden). 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

    1 Citation (Scopus)

    The majority of newly diagnosed myeloma patients do not fulfill the inclusion criteria in clinical phase III trials

    Klausen, T. W., Gregersen, H., Abildgaard, N., Andersen, N. F., Frølund, U. C., Gimsing, P., Helleberg, C. & Vangsted, A. J., Feb 2019, In : Leukemia. 33, 2, p. 546-549 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

    2018
    2 Citations (Scopus)

    A Danish national effort of BRCA1/2 variant classification

    Pedersen, I. S., Schmidt, A. Y., Bertelsen, B., Ernst, A., Andersen, C. L. T., Kruse, T., Rossing, M. & Thomassen, M., 2018, In : Acta Oncologica. 57, 1, p. 159-162 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

    2 Citations (Scopus)

    Associations between cohabitation status, treatment, and outcome in AML patients: a national population-based study

    Østgård, L. S. G., Nørgaard, M., Medeiros, B. C., Severinsen, M. T., Friis, L. S., Marcher, C. W., Schoellkopf, C. & Nørgaard, J. M., 2018, In : Blood. 131, 24, p. 2730-2733 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

    6 Citations (Scopus)

    CAD is an independent risk factor for stroke among patients with atrial fibrillation

    Steensig, K., Olesen, K. K. W., Thim, T., Nielsen, J. C., Jensen, S. E., Jensen, L. O., Kristensen, S. D., Bøtker, H. E., Lip, G. Y. H. & Maeng, M., 13 Nov 2018, In : Journal of the American College of Cardiology. 72, 20, p. 2540-2542 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

    3 Citations (Scopus)

    Drug concentrations and anti-drug antibodies during treatment with biosimilar infliximab (CT-P13) in routine care

    Glintborg, B., Kringelbach, T., Bolstad, N., Warren, D. J., Eng, G., Sørensen, I. J., Loft, A. G., Hendricks, O., Hansen, I., Linauskas, A., Nordin, H., Kristensen, S., Lindegaard, H., Jensen, D. V., Goll, G. L., Høgdall, E., Gehin, J., Enevold, C., Nielsen, C. H., Krogh, N. S. & 2 others, Johansen, J. S. & Hetland, M. L., 2018, In : Scandinavian Journal of Rheumatology. 47, 5, p. 418–421 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

    1 Citation (Scopus)

    Evolution of relative survival for acute promyelocytic leukemia patients alive at landmark time-points: a population-based study

    Biccler, J. L., Østgård, L. S. G., Severinsen, M. T., Marcher, C. W., Møller, P., Schöllkopf, C., Friis, L. S., Bøgsted, M., Jakobsen, L. H., El-Galaly, T. C. & Nørgaard, J. M., 2018, In : Leukemia. 32, 10, p. 2263-2265 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

    5 Citations (Scopus)
    105 Downloads (Pure)

    Incidence and predictors of infection among patients prior to treatment of chronic lymphocytic leukemia: a Danish nationwide cohort study

    Andersen, M. A., Eriksen, C. T., Brieghel, C., Biccler, J. L., da Cunha-Bang, C., Helleberg, M. & Niemann, C. U., 2018, In : Haematologica. 103, 7, p. e300-e303 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

    Open Access
    File
    2 Citations (Scopus)

    Real world data on rituximab maintenance therapy after frontline immunochemotherapy in grade 1-3a follicular lymphoma

    Bech, R. S., Nielsen, K. L., Larsen, T. S., Bentzen, H. H. N., Lynggaard, L. S., Do, T. H., Braendstrup, P., Brady, J., Mikhaeel, N. G., Dybkaer, K., Johnsen, H. E., Jensen, P., Bøgsted, M. & El-Galaly, T. C., 2018, In : British Journal of Haematology. 182, 2, p. 297-301 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

    2 Citations (Scopus)
    16 Downloads (Pure)

    Six cycles of R-CHOP-21 are not inferior to eight cycles for treatment of diffuse large B-cell lymphoma: a Nordic Lymphoma Group population-based study

    Wästerlid, T., Biccler, J. L., Brown, P. N., Bøgsted, M., Enblad, G., Jørgensen, J. M., Christensen, J. H., Wahlin, B. E., Smedby, K. E., El-Galaly, T. C. & Jerkeman, M., 2018, In : Annals of Oncology. 29, 8, p. 1882–1883 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

    Open Access
    File
    2 Citations (Scopus)

    Skewed ratio between type 1 and type 2 calreticulin mutations in essential thrombocytosis patients with concomitant Janus kinase 2 V617F mutation

    Haunstrup, L. M., Ebbesen, L. H., Hansen, M., Severinsen, M. T. & Aggerholm, A., Dec 2018, In : Experimental Hematology. 68, p. 62-65 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

    Janus Kinase 2
    Calreticulin
    Thrombocytosis
    Mutation
    Neoplasms
    2 Citations (Scopus)

    The management and survival outcomes of nasopharyngeal cancer in the Nordic countries

    Mäkitie, A., Ruuskanen, M., Bentzen, J., Brun, E., Gebre-Medhin, M., Friesland, S., Marsk, E., Hammarstedt-Nordenvall, L., Gille, E., Reizenstein, J., Adell, G., Farnebo, L., Rzepecki, J., Haugen, H., Söderström, K., Zackrisson, B., Bergström, S., Lödén, B., Cederblad, L., Laurell, G. & 18 others, Smeland, E., Folkvard Evensen, J., Lund, J. Å., Tøndel, H., Karlsdottir, Å., Jóhannsson, J., Johansen, J., Kristensen, C. A., Jensen, K., Andersen, L. J., Koivunen, P., Korpela, M., Voutilainen, L., Wigren, T., Minn, H., Joensuu, H., Overgaard, J. & Saarilahti, K., Apr 2018, In : Acta Oncologica. 57, 4, p. 557-560 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

    Transmission of rheumatoid arthritis through blood transfusion: a retrospective cohort study

    Just, S. A., Rostgaard, K., Titlestad, K., Edgren, G., Erikstrup, C., Ullum, H., Pedersen, O. B., Nielsen, K. R., Askling, J., Lindegaard, H. & Hjalgrim, H., 2018, In : Annals of the Rheumatic Diseases. 77, 10, p. 1536-1537 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

    2017
    125 Downloads (Pure)

    Adolescent sense of coherence and antidepressants usage 11 years later

    Würtz, E. T., Mortensen, J. T. & Fonager, K., 2017, In : Journal of Family Medicine and Disease Prevention. 3, 3, 3 p., 066.

    Research output: Contribution to journalLetterResearchpeer-review

    Open Access
    File
    2 Citations (Scopus)

    Behind the scenes in urinalysis: to report or not to report

    Azuz, S., Gertsen, J. B., Rasmussen, S. S., Jensen, C. S., Jansåker, E. F. & Fuglsang-Damgaard, D., 2017, In : Infectious Diseases. 49, 9, p. 712-715 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

    7 Citations (Scopus)
    55 Downloads (Pure)

    Central nervous system infections in the absence of cerebrospinal fluid pleocytosis

    Erdem, H., Ozturk-Engin, D., Cag, Y., Senbayrak, S., Inan, A., Kazak, E., Elaldi, N., Savasci, U., Vahaboglu, H., Hasbun, R., ID-IRI study group & Sørensen, S. M., 1 Dec 2017, In : International Journal of Infectious Diseases. 65, p. 107-109 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

    Open Access
    File
    Central Nervous System Infections
    Leukocytosis
    Cerebrospinal Fluid
    Pneumococcal Meningitis
    Neurosyphilis
    8 Citations (Scopus)

    Effect of reduced renal function on time in therapeutic range among anticoagulated atrial fibrillation patients

    Bonde, A. N., Lip, G. Y. H., Kamper, A-L., Staerk, L., Torp-Pedersen, C., Gislason, G. H. & Olesen, J. B., 14 Feb 2017, In : Journal of the American College of Cardiology. 69, 6, p. 752-753

    Research output: Contribution to journalLetterResearchpeer-review

    5 Citations (Scopus)

    Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations

    Visco, C., Wang, J., Tisi, M. C., Deng, L., D'Amore, E. S. G., Tzankov, A., Montes-Moreno, S., Dybkær, K., Bhagat, G., Hsi, E. D., van Krieken, J. H., Ponzoni, M., Ferreri, A. J. M., Møller, M. B., Piris, M. A., Medeiros, L. J., Xu-Monette, Z. Y. & Young, K. H., 2017, In : British Journal of Cancer. 117, 11, p. 1685-1688 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

    Open Access
    Lymphoma, Large B-Cell, Diffuse
    Hepacivirus
    Non-Hodgkin's Lymphoma
    Gene Expression Profiling
    B-Cell Lymphoma
    62 Citations (Scopus)

    Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

    Milne, R. L., Kuchenbaecker, K. B., Michailidou, K., Beesley, J., Kar, S., Lindström, S., Hui, S., Lemaçon, A., Soucy, P., Dennis, J., Jiang, X., Rostamianfar, A., Finucane, H., Bolla, M. K., McGuffog, L., Wang, Q., Aalfs, C. M., Adams, M., Adlard, J., Agata, S. & 31 others, Ahmed, S., Ahsan, H., Aittomäki, K., Al-Ejeh, F., Allen, J., Ambrosone, C. B., Amos, C. I., Andrulis, I. L., Anton-Culver, H., Antonenkova, N. N., Arndt, V., Arnold, N., Aronson, K. J., Auber, B., Auer, P. L., Ausems, M. G. E. M., Azzollini, J., Bacot, F., Balmaña, J., Barile, M., Barjhoux, L., Barkardottir, R. B., Barrdahl, M., Barnes, D., Barrowdale, D., Baynes, C., Beckmann, M. W., Benitez, J., Bermisheva, M., Pedersen, I. S. & ABCTB Investigators, 2017, In : Nature Genetics. 49, 12, p. 1767-1778 12 p.

    Research output: Contribution to journalLetterResearchpeer-review

    Open Access
    Estrogen Receptors
    Breast Neoplasms
    Genome-Wide Association Study
    Mutation
    Disease Susceptibility
    13 Citations (Scopus)

    Incidence and prevalence of multiple endocrine neoplasia 2B in Denmark: a nationwide study

    Mathiesen, J. S., Kroustrup, J. P., Vestergaard, P., Madsen, M., Stochholm, K., Poulsen, P. L., Krogh Rasmussen, Å., Feldt-Rasmussen, U., Schytte, S., Pedersen, H. B., Hahn, C. H., Bentzen, J., Gaustadnes, M., Ørntoft, T. F., Hansen, T. V. O., Nielsen, F. C., Brixen, K., Frederiksen, A. L. & Godballe, C., 2017, In : Endocrine - Related Cancer. 24, 7, p. L39-L42 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

    Multiple Endocrine Neoplasia
    Denmark
    Incidence
    Mutation
    Proto-Oncogenes

    Predictive value of galectin-1 in the development and progression of HIV-associated lymphoma

    Vase, M. Ø., Ludvigsen, M., Bendix, K., Dutoit, S. H., Hjortebjerg, R., Petruskevicius, I., Møller, M. B., Pedersen, G., Denton, P. W., Honoré, B., Rabinovich, G. A., Larsen, C. S. & d'Amore, F., 2017, In : AIDS. 31, 16, p. 2311-2313 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

    1 Citation (Scopus)

    The population attributable fraction of occupational COPD among Danish women

    Würtz, E., Schlünssen, V., Malling, T., Hansen, J. G. & Omland, Ø., 2017, In : ERJ Open Research. 3, 2

    Research output: Contribution to journalLetterResearchpeer-review

    Open Access
    Chronic Obstructive Pulmonary Disease
    Population
    2016
    5 Citations (Scopus)
    9 Citations (Scopus)

    D-Dimer predicts prognosis and non-resectability in patients with pancreatic cancer: a prospective cohort study

    Stender, M. T., Larsen, A. C., Sall, M. & Thorlacius-Ussing, O., 2016, In : Blood Coagulation and Fibrinolysis. 27, 5, p. 597-601 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

    Pancreatic Neoplasms
    Cohort Studies
    Prospective Studies
    Confidence Intervals
    Survival
    3 Citations (Scopus)

    Early coagulation activation precedes the development of acute lung injury after cardiac surgery

    Rasmussen, B. S., Maltesen, R. G., Pedersen, S. & Kristensen, S. R., Jan 2016, In : Thrombosis Research. 139, p. 82-84 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

    15 Citations (Scopus)
    50 Downloads (Pure)

    Influenza vaccine effectiveness in adults 65 years and older, Denmark, 2015/16: a rapid epidemiological and virological assessment

    Emborg, H., Krause, T. G., Nielsen, L., Thomsen, M. K., Christiansen, C. B., Skov, M. N., Nielsen, X. C., Sandborg Weinreich, L., Fischer, T. K., Rønn, J. & Trebbien, R., 2016, In : Eurosurveillance (Online). 21, 14, p. 2-7 6 p.

    Research output: Contribution to journalLetterResearchpeer-review

    Open Access
    File
    12 Citations (Scopus)

    Intralymphatic immunotherapy induces allergen specific plasmablasts and increases tolerance to skin prick testing in a pilot study

    Schmid, J. M., Nezam, H., Madsen, H. H. T., Schmitz, A. & Hoffmann, H. J., 2016, In : Clinical and Translational Allergy. 6, 4 p., 19.

    Research output: Contribution to journalLetterResearchpeer-review

    Open Access
    Immunologic Desensitization
    Allergens
    Skin
    Poaceae
    Injections
    11 Citations (Scopus)

    Prospective study of bicycling and risk of coronary heart disease in Danish men and women

    Blond, K., Jensen, M. K., Rasmussen, M. G., Overvad, K., Tjønneland, A., Østergaard, L. & Grøntved, A., 1 Nov 2016, In : Circulation. 134, 18, p. 1409-1411 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

    2015
    9 Citations (Scopus)

    Aggressive Medullary Thyroid Carcinoma in a Ten-Year-Old Patient with Multiple Endocrine Neoplasia 2B Due to the A883F Mutation

    Mathiesen, J. S., Stochholm, K., Poulsen, P. L., Vestergaard, E. M., Christiansen, P. & Vestergaard, P., Jan 2015, In : Thyroid. 25, 1, p. 139-140 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

    A novel chemosensitivity profiling platform for small acute lymphoblastic leukemia cell populations

    Groth-Pedersen, L., Chen, Y-H., Faber, M., Valentin, R., Albertsen, B. K., Wehner, P. S., Rosthøj, S., Frandsen, T. L., Marquart, H. V. & Schmiegelow, K., 2015, In : Leukemia and Lymphoma. 56, 7, p. 2208-2211 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

    13 Citations (Scopus)

    Causes of early death in multiple myeloma patients who are ineligible for high-dose therapy with hematopoietic stem cell support: A study based on the nationwide Danish Myeloma Database

    Holmström, M. O., Gimsing, P., Abildgaard, N., Andersen, N. F., Helleberg, C., Clausen, N. A. T., Klausen, T. W., Frederiksen, M., Kristensen, D. L., Larsen, H., Pedersen, P. T., Andersen, K. T., Pedersen, R. S., Jensen, B. A., Gregersen, H. & Vangsted, A. J., 2015, In : American Journal of Hematology. 90, 4, p. E73-74 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

    Open Access
    3 Citations (Scopus)

    Circulating tumor necrosis factor-α and YKL-40 level is associated with remission status following salvage therapy in relapsed non-Hodgkin lymphoma

    El-Galaly, T. C., Bilgrau, A. E., Gaarsdal, E., Klausen, T. W., Pedersen, L. M., Nielsen, K. R., Bæch, J., Bøgsted, M., Dybkær, K., Johansen, J. S. & Johnsen, H. E., 2015, In : Leukemia and Lymphoma. 56, 8, p. 2476-2478 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

    2 Citations (Scopus)

    Correlation between pretreatment FDG-PET biological target volume and location of T-site failure after definitive radiation therapy for head and neck cancers

    Sand, H. M. B., Brunø, A. H., Andersen, L. J. & Carl, J., 2015, In : Acta Oncologica. 54, 9, p. 1682-1685 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

    Open Access

    Eksantem hos en hiv-positiv patient: Månedens billede

    Translated title of the contribution: Tuberkuløs spondylitis med psoas-abscesSørensen, S. M., 2015, In : Ugeskrift for Laeger. 177, 24, p. 2335 V66776.

    Research output: Contribution to journalLetterResearchpeer-review

    Open Access

    Elephantiasis nostras verrucosa

    Hagen, T. L., 2015, In : Ugeskrift for Laeger. 177, 25, p. 2434 V66925.

    Research output: Contribution to journalLetterResearchpeer-review

    Open Access

    Fourniers gangræn : månedens billede

    Translated title of the contribution: Fourniers gangræn.Carøe, T. & Jønler, M., 2 Feb 2015, In : Ugeskrift for Laeger. 177, 6, p. 271 V65952.

    Research output: Contribution to journalLetterResearchpeer-review

    13 Citations (Scopus)

    Quality assurance of radiation therapy for head and neck cancer patients treated in DAHANCA 10 randomized trial

    Hansen, C. R., Johansen, J., Kristensen, C. A., Smulders, B., Andersen, L. J., Samsøe, E., Andersen, E., Petersen, J. B. B., Overgaard, J. & Grau, C., 2015, In : Acta Oncologica. 54, 9, p. 1669-1673 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

    Open Access