• Fredrik Bajers Vej 7 A2

    DK-9220 Aalborg East


Organization profile

Organisation profile

About Center for Neuroplasticity and Pain (CNAP)

Center for Neuroplasticity and Pain (CNAP) is a Center of Excellence at the Department of Health Science and Technology, funded by the Danish National Research Foundation in the period 2015-2025.

Our vision

The ambition of CNAP is to identify and modulate key features of human pain neuroplasticity. We keenly believe that this can be achieved through a systematic engineering approach, including provoking, probing and modulation of the dynamic neuroplastic properties of the pain system.

Our approach

CNAP applies a basic research approach where new advanced biomedical provocation and probing platforms are being discovered and applied to study novel aspects of the human pain neuroplasticity. When an injury results in acute pain, the nervous system undergoes an adaptive neuroplastic response resulting in an increase in sensitivity. After some time, the pain neuroplasticity is normalized as the injury heals. In some cases, such neuroplastic processes fail to normalize during convalescence, and acute pain develops into chronic pain with hypersensitivity. The continuing pain after injury resolution may be caused by maladaptive pain neuroplasticity. In contrast, advantageous neuroplasticity permits the nervous system to cope with challenges such as maladaptive pain neuroplasticity to help returning to a pain-free state.

Interdisciplinary, international cooperation, and research training combined with the capacity of leading researchers is the core research philosophy of CNAP. Thus, all our research groups are highly interdisciplinary and include experts within e.g. biomedical engineering, neuropsychology, pharmacology, biophysics, and medicine. To secure international excellence, CNAP strives for an equal distribution between genders and between national and international staff.

Research groups

CNAP consists of researchers from four different research groups:

  • Neural Engineering and Neurophysiology
  • Integrative Neuroscience
  • Pain and Motor System Plasticity
  • Translational Pain Biomarkers

Network Dive into details by clicking on the dots.


Research Output

Activation of the descending pain modulatory system using cuff pressure algometry: Back translation from man to rat

Cummins, TM., Kucharczyk, M., Graven-Nielsen, T. & Bannister, K., 29 Apr 2020, In : European Journal of Pain.

Research output: Contribution to journalJournal articleResearchpeer-review

  • Activity Modification and Knee Strengthening for Osgood-Schlatter Disease: A Prospective Cohort Study

    Rathleff, M. S., Winiarski, L., Krommes, K., Graven-Nielsen, T., Hölmich, P., Olesen, J. L., Holden, S. & Thorborg, K., Apr 2020, In : Orthopaedic Journal of Sports Medicine. 8, 4, 2325967120911106.

    Research output: Contribution to journalJournal articleResearchpeer-review

    Open Access
  • 9 Downloads (Pure)

    Alterations in pro-nociceptive and anti-nociceptive mechanisms in patients with low back pain: a systematic review with meta-analysis

    McPhee, M. E., Vaegter, H. B. & Graven-Nielsen, T., Mar 2020, In : Pain. 161, 3, p. 464-475 12 p.

    Research output: Contribution to journalReview articleResearchpeer-review

  • Datasets

    C19 SymMaps survey data

    Boudreau, S. (Data Collector), VBN, 1 Apr 2020



    Best Abstract Prize

    Petersen, Kristian Kjær (Recipient) & Larsen, Dennis Boye (Recipient), 7 Sep 2019

    Prize: Conference prizes

    Best poster abstract

    Tøttrup, Lea (Recipient), 2019

    Prize: Conference prizes

    Best poster award

    Galve Villa, Maria (Recipient), 2019

    Prize: Conference prizes


    Girls' Day in Science AAU 2019

    Amelia Reimer Borregaard (Organizer), , Rikke Hagensby Jensen (Organizer), , Anna Lyhne Jensen (Participant), , Anne Marie Svane (Participant), , Anne Juhler Hansen (Participant), , Ann-Louise Andersen (Participant), , Belinda Nors (Participant), , Cejna Anna Quist-Jensen (Participant), , Katrine Vogt Møller (Participant), , Kirstine Meyer Frandsen (Participant), , Lea Tøttrup (Participant), , Marike Koch van den Broek (Participant), , Lone Kørnøv (Participant), , Janne Jul Jensen (Participant), , Vibeke R Borregaard (Participant), & Lotte Sørensen (Participant)

    2 Oct 2019

    Activity: Attending an eventOrganisation or participation in workshops, courses, or seminars


    Phenotyping of multiple biofluids for liquid biomarkers for diagnostics and personalized medicine

    Allan Stensballe (Lecturer), , Sten Rasmussen (Lecturer), , Lars Arendt-Nielsen (Lecturer), & Thomas Bouet Guldbæk Poulsen (Lecturer)

    18 Sep 2019

    Activity: Talks and presentationsConference presentations


    Press / Media

    Skal patienten have superviseret træning eller en pjece?

    Lars Arendt-Nielsen & Ole Simonsen


    1 item of Media coverage

    Press/Media: Press / Media

    Ny tvivl om bækkenløsning

    Thorvaldur Palsson & Thomas Graven-Nielsen


    1 item of Media coverage

    Press/Media: Press / Media