• Fredrik Bajers Vej 3B

    DK-9220 Aalborg Øst

    Denmark

Organization profile

Organisation profile

Background
Stem cells are becoming an ever more important element in medical therapies. Until recently, stem cells were almost exclusively used to repopulate bone marrow depleted after chemo- and/or radiotherapy. They are now also used in a number of experimental therapies ranging from inborn errors of metabolism, endocrine and cardiovascular disorders to various neurological conditions.

Extensive global research is being done on the potential of human stem cells, and a number of private companies are preparing to enter the market.

The Laboratory for Stem Cell Research has a background in in vitro oxygen tension control of transcription regulation of molecular processes in human tumour cells and is now spearheading the basic and translational research into novel regenerative therapies based on the use of embryonic and somatic stem cells. The laboratory is focused on the development of innovative interdisciplinary approaches to control the fate of stem cells and devise original clinically applicable cell- and tissue-based products.

Main activities
The main research activities of the laboratory are focused on four basic areas:

  1. The role of oxygen in the control of the fate of stem cells
  2. The use of adipose stem cells in the construction of a novel cartilage implant
  3. The use of embryonic stem cells in the treatment of limbal stem cells deficiency
  4. The use of mesenchymal stem cells in the treatment of myocardial failure

The laboratory has recently set up a unique cell culture facility that enables manipulation and continuous growth of the cells in a fully controlled atmosphere. This workstation makes possible investigations on the responses of the embryonic (ESC) and mesenchymal (MSC) stem cells to hypoxic conditions. The molecular mechanisms underlying maintenance of pluripotential state of ESCs or differentiation of MSC into various specific lineages are investigated through specific genes as well as transcriptomic, proteomic, genomic, and miRNA studies.

Regarding the novel approaches to treat the cartilage defects/osteoarthritis, specific forms of blindness, and myocardial infarction/failure, we are exploring the therapeutic potential of both the MSCs and ESCs. We are attempting to translate the basic knowledge regarding the biology and molecular biology of the stem cells into advanced tissue engineering and cell-based procedures applicable in routine medical practice. To that end, the laboratory is collaborating with several prestigious clinics in Denmark and abroad.

Future perspectives
Our long-term goal is to use stem cells for ex vivo production of biological spare parts.

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Stem Cells Medicine & Life Sciences
Stem cells Chemical Compounds
Spermatozoa Medicine & Life Sciences
Tissue Engineering Medicine & Life Sciences
Tissue Chemical Compounds
Biomechanical Phenomena Medicine & Life Sciences
Diamond Medicine & Life Sciences
Boron Medicine & Life Sciences

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Projects 2002 2016

Cancer stem cells

Duroux, M., Pilgaard, L. & Zachar, V.

01/01/2011 → …

Project: Research

Reconstruction of ocular surface based on the somatic stem cells

Zachar, V., Søndergaard, C., Yang, S. & Emmersen, J.

01/01/2011 → …

Project: Research

Research Output 2002 2019

Design and Characterization of a Tissue-Engineered Trilayer Chitosan, and PLA Based Scaffold for Urethral Tissue Repair

Abbas, T. & Pennisi, P., 2019, 30th Congress of the ESPU: Abstract Book. Lyon: ESPU Congress, p. 47 S1-6

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

8 Downloads (Pure)

From Acellular Matrices to Smart Polymers: Degradable Scaffolds that are Transforming the Shape of Urethral Tissue Engineering

Abbas, T. O., Yalcin, H. C. & Pennisi, C. P., 10 Apr 2019, In : International Journal of Molecular Sciences . 20, 7

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
File
tissue engineering
Tissue Engineering
Scaffolds (biology)
Tissue engineering
Scaffolds

In Vivo Assessment of the Biomechanics of Rabbit Urethra: an Important Aid in Optimized Translatable Urethral Regenerative Medicine Experiment

Abbas, T. & Pennisi, P., 2019, 30th Congress of the ESPU: Abstract Book. Lyon: ESPU Congress, p. 47 S1-5

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

Activities 2015 2017

  • 3 Talks and presentations in private or public companies
  • 2 Conference presentations
  • 1 Membership of review committee

Advances in semen analysis techniques and functional tests

Hiva Alipour (Speaker)
31 May 2017

Activity: Talks and presentationsTalks and presentations in private or public companies

Dansk Fertilitetsselskabs Årsmøde 2016

Hiva Alipour (Speaker)
13 Mar 2016

Activity: Talks and presentationsConference presentations

Improved sperm kinematics in consecutive sperm samples

Hiva Alipour (Speaker)
1 May 2017

Activity: Talks and presentationsTalks and presentations in private or public companies

Press / Media

Tre forskertalenter fik legater

Simone Riis Porsborg

21/02/2019

1 item of media coverage

Press/Media: Press / Media

Legat til talentfuld diabetesforsker

Simone Riis Porsborg

03/12/2018

1 item of media coverage

Press/Media: Press / Media