Research Output 2016 2019

2019

4 week treatment for hepatitis C: A randomized controlled trial (4RIBC)

Madsen, L. W., Ovrehus, A., Gerstoft, J., Weis, N., Barfod, T. S., Laursen, A., Krarup, H., Ernst, A. & Christensen, P. B., Apr 2019, In : Journal of Hepatology. 70, 1, Suppl., p. e247-e248 2 p., THU-193.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Dominguez-Valentin, M., Sampson, J. R., Seppälä, T. T., Ten Broeke, S. W., Plazzer, J-P., Nakken, S., Engel, C., Aretz, S., Jenkins, M. A., Sunde, L., Bernstein, I., Capella, G., Balaguer, F., Thomas, H., Evans, D. G., Burn, J., Greenblatt, M., Hovig, E., de Vos Tot Nederveen Cappel, W. H., Sijmons, R. H. & 68 others, Bertario, L., Tibiletti, M. G., Cavestro, G. M., Lindblom, A., Della Valle, A., Lopez-Köstner, F., Gluck, N., Katz, L. H., Heinimann, K., Vaccaro, C. A., Büttner, R., Görgens, H., Holinski-Feder, E., Morak, M., Holzapfel, S., Hüneburg, R., Knebel Doeberitz, M. V., Loeffler, M., Rahner, N., Schackert, H. K., Steinke-Lange, V., Schmiegel, W., Vangala, D., Pylvänäinen, K., Renkonen-Sinisalo, L., Hopper, J. L., Win, A. K., Haile, R. W., Lindor, N. M., Gallinger, S., Le Marchand, L., Newcomb, P. A., Figueiredo, J. C., Thibodeau, S. N., Wadt, K., Therkildsen, C., Okkels, H., Ketabi, Z., Moreira, L., Sánchez, A., Serra-Burriel, M., Pineda, M., Navarro, M., Blanco, I., Green, K., Lalloo, F., Crosbie, E. J., Hill, J., Denton, O. G., Frayling, I. M., Rødland, E. A., Vasen, H., Mints, M., Neffa, F., Esperon, P., Alvarez, K., Kariv, R., Rosner, G., Pinero, T. A., Gonzalez, M. L., Kalfayan, P., Tjandra, D., Winship, I. M., Macrae, F., Möslein, G., Mecklin, J-P., Nielsen, M. & Møller, P., 24 Jul 2019, In : Genetics in Medicine.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Hereditary Nonpolyposis Colorectal Neoplasms
DNA Mismatch Repair
Neoplasm Genes
Databases
Endometrial Neoplasms

Detection of PMS2 mutations by screening hereditary nonpolyposis colon cancer families from Denmark and Sweden

Okkels, H., Lagerstedt-Robinsson, K., Wikman, F. P., Hansen, T. V. O., Lolas, I., Lindberg, L. J. & Krarup, H. B., 1 Sep 2019, In : Genetic Testing and Molecular Biomarkers. 23, 9, p. 688-695 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Hereditary Nonpolyposis Colorectal Neoplasms
Denmark
Sweden
DNA Mismatch Repair
Mutation
1 Citation (Scopus)

Discriminatory rapid tests cause HIV-type misclassification-evaluation of three rapid tests using clinical samples from Guinea-Bissau

Hønge, B. L., Jespersen, S., Medina, C., Té, D. D. S., da Silva, Z. J., Christiansen, M., Kjerulff, B., Laursen, A. L., Wejse, C., Krarup, H., Erikstrup, C. & Bissau HIV Cohort study group, 4 Jun 2019, In : Transactions of the Royal Society of Tropical Medicine and Hygiene.

Research output: Contribution to journalJournal articleResearchpeer-review

Guinea-Bissau
HIV-2
HIV-1
HIV
Dual (Psychiatry) Diagnosis
1 Citation (Scopus)

Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants

Jensen, S. B., Fahnøe, U., Pham, L. V., Serre, S., Tang, Q., Ghanem, L., Pedersen, M. S., Ramirez, S., Humes, D., Pihl, A. F., Filskov, J., Sølund, C. S., Dietz, J., Fourati, S., Pawlotsky, J-M., Sarrazin, C., Weis, N., Schønning, K., Krarup, H., Bukh, J. & 1 others, Gottwein, J. M., Apr 2019, In : Hepatology.

Research output: Contribution to journalJournal articleResearchpeer-review

Protease Inhibitors
Hepacivirus
Genotype
Genome
Therapeutics
1 Citation (Scopus)
15 Downloads (Pure)

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Ferreira, M. A., Gamazon, E. R., Al-Ejeh, F., Aittomäki, K., Andrulis, I. L., Anton-Culver, H., Arason, A., Arndt, V., Aronson, K. J., Arun, B. K., Asseryanis, E., Azzollini, J., Balmaña, J., Barnes, D. R., Barrowdale, D., Beckmann, M. W., Behrens, S., Benitez, J., Bermisheva, M., Białkowska, K. & 196 others, Blomqvist, C., Bogdanova, N. V., Bojesen, S. E., Bolla, M. K., Borg, A., Brauch, H., Brenner, H., Broeks, A., Burwinkel, B., Caldés, T., Caligo, M. A., Campa, D., Campbell, I., Canzian, F., Carter, J., Carter, B. D., Castelao, J. E., Chang-Claude, J., Chanock, S. J., Christiansen, H., Chung, W. K., Claes, K. B. M., Clarke, C. L., GC-HBOC Study Collaborators, GEMO Study Collaborators, EMBRACE Collaborators, Couch, F. J., Cox, A., Cross, S. S., Czene, K., Daly, M. B., de la Hoya, M., Dennis, J., Devilee, P., Diez, O., Dörk, T., Dunning, A. M., Dwek, M., Eccles, D. M., Ejlertsen, B., Ellberg, C., Engel, C., Eriksson, M., Fasching, P. A., Fletcher, O., Flyger, H., Friedman, E., Frost, D., Gabrielson, M., Gago-Dominguez, M., Ganz, P. A., Gapstur, S. M., Garber, J., García-Closas, M., García-Sáenz, J. A., Gaudet, M. M., Giles, G. G., Glendon, G., Godwin, A. K., Goldberg, M. S., Goldgar, D. E., González-Neira, A., Greene, M. H., Gronwald, J., Guénel, P., Haiman, C. A., Hall, P., Hamann, U., He, W., Heyworth, J., Hogervorst, F. B. L., Hollestelle, A., Hoover, R. N., Hopper, J. L., Hulick, P. J., Humphreys, K., Imyanitov, E. N., HEBON Investigators, BCFR Investigators, ABCTB Investigators, Isaacs, C., Jakimovska, M., Jakubowska, A., James, P. A., Janavicius, R., Jankowitz, R. C., John, E. M., Johnson, N., Joseph, V., Karlan, B. Y., Khusnutdinova, E., Kiiski, J. I., Ko, Y-D., Jones, M. E., Konstantopoulou, I., Kristensen, V. N., Laitman, Y., Lambrechts, D., Lazaro, C., Leslie, G., Lester, J., Lesueur, F., Lindström, S., Long, J., Loud, J. T., Lubiński, J., Makalic, E., Mannermaa, A., Manoochehri, M., Margolin, S., Maurer, T., Mavroudis, D., McGuffog, L., Meindl, A., Menon, U., Michailidou, K., Miller, A., Montagna, M., Moreno, F., Moserle, L., Mulligan, A. M., Nathanson, K. L., Neuhausen, S. L., Nevanlinna, H., Nevelsteen, I., Nielsen, F. C., Nikitina-Zake, L., Nussbaum, R. L., Offit, K., Olah, E., Olopade, O. I., Olsson, H., Osorio, A., Papp, J., Park-Simon, T-W., Parsons, M. T., Pedersen, I. S., Peixoto, A., Peterlongo, P., Pharoah, P. D. P., Plaseska-Karanfilska, D., Poppe, B., Presneau, N., Radice, P., Rantala, J., Rennert, G., Risch, H., Saloustros, E., Sanden, K., Sawyer, E. J., Schmidt, M. K., Schmutzler, R. K., Sharma, P., Shu, X-O., Simard, J., Singer, C. F., Soucy, P., Southey, M. C., Spinelli, J. J., Spurdle, A. B., Stone, J., Swerdlow, A. J., Tapper, W. J., Taylor, J. A., Teixeira, M. R., Terry, M. B., Teulé, A., Thomassen, M., Thöne, K., Thull, D. L., Tischkowitz, M., Toland, A. E., Torres, D., Truong, T., Tung, N., Vachon, C. M., van Asperen, C. J., van den Ouweland, A. M. W., van Rensburg, E. J., Vega, A., Viel, A., Wang, Q., Wappenschmidt, B., Weitzel, J. N., Wendt, C., Winqvist, R., Yang, X. R., Yannoukakos, D., Ziogas, A., Kraft, P., Antoniou, A. C., Zheng, W., Easton, D. F., Milne, R. L., Beesley, J. & Chenevix-Trench, G., 15 Apr 2019, In : Nature Communications. 10, 1, 1741.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
genome
Genome-Wide Association Study
loci
Transcriptome
breast
1 Citation (Scopus)

Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification

Parsons, M. T., Tudini, E., Li, H., Hahnen, E., Wappenschmidt, B., Feliubadaló, L., Aalfs, C. M., Agata, S., Aittomäki, K., Alducci, E., Alonso-Cerezo, M. C., Arnold, N., Auber, B., Austin, R., Azzollini, J., Balmaña, J., Barbieri, E., Bartram, C. R., Blanco, A., Blümcke, B. & 197 others, Bonache, S., Bonanni, B., Borg, Å., Bortesi, B., Brunet, J., Bruzzone, C., Bucksch, K., Cagnoli, G., Caldés, T., Caliebe, A., Caligo, M. A., Calvello, M., Capone, G. L., Caputo, S. M., Carnevali, I., Carrasco, E., Caux-Moncoutier, V., Cavalli, P., Cini, G., Clarke, E. M., Concolino, P., Cops, E. J., Cortesi, L., Couch, F. J., Darder, E., de la Hoya, M., Dean, M., Debatin, I., del Valle, J., Delnatte, C., Derive, N., Diez, O., Ditsch, N., Domchek, S. M., Dutrannoy, V., Eccles, D. M., Ehrencrona, H., Enders, U., Evans, D. G., Faust, U., Felbor, U., Feroce, I., Fine, M., Galvao, H. C. R., Gambino, G., Gehrig, A., Gensini, F., Gerdes, A-M., Germani, A., Giesecke, J., Gismondi, V., Gómez, C., Gómez Garcia, E. B., González, S., Grau, E., Grill, S., Gross, E., Guerrieri-Gonzaga, A., Guillaud-Bataille, M., Gutiérrez-Enríquez, S., Haaf, T., Hackmann, K., Hansen, T. V. O., Harris, M., Hauke, J., Heinrich, T., Hellebrand, H., Herold, K. N., Honisch, E., Horvath, J., Houdayer, C., Hübbel, V., Iglesias, S., Izquierdo, A., James, P. A., Janssen, L. A. M., Jeschke, U., Kaulfuß, S., Keupp, K., Kiechle, M., Kölbl, A., Krieger, S., Kruse, T. A., Kvist, A., Lalloo, F., Larsen, M., Lattimore, V. L., Lautrup, C., Ledig, S., Leinert, E., Lewis, A. L., Lim, J., Loeffler, M., López-Fernández, A., Lucci-Cordisco, E., Maass, N., Manoukian, S., Marabelli, M., Matricardi, L., Meindl, A., Michelli, R. D., Moghadasi, S., Moles-Fernández, A., Montagna, M., Montalban, G., Monteiro, A. N., Montes, E., Mori, L., Moserle, L., Müller, C. R., Mundhenke, C., Naldi, N., Nathanson, K. L., Navarro, M., Nevanlinna, H., Nichols, C. B., Niederacher, D., Nielsen, H. R., Ong, K., Pachter, N., Palmero, E. I., Papi, L., Pedersen, I. S., Peissel, B., Pérez-Segura, P., Pfeifer, K., Pineda, M., Pohl-Rescigno, E., Poplawski, N. K., Porfirio, B., Quante, A. S., Ramser, J., Rei, R. M., Revillion, F., Rhiem, K., Riboli, B., Ritter, J., Rivera, D., Rofes, P., Rump, A., Salinas, M., Sánchez de Abajo, A. M., Schmidt, G., Schoenwiese, U., Seggewiß, J., Solanes, A., Steinemann, D., Stiller, M., Stoppa-Lyonnet, D., Sullivan, K. J., Susman, R., Sutter, C., Tavtigian, S. V., Teo, S. H., Teulé, A., Thomassen, M., Tibiletti, M. G., Tognazzo, S., Toland, A. E., Tornero, E., Törngren, T., Torres-Esquius, S., Toss, A., Trainer, A. H., van Asperen, C. J., van Mackelenbergh, M. T., Varesco, L., Vargas-Parra, G., Varon, R., Vega, A., Velasco, Á., Vesper, A-S., Viel, A., Vreeswijk, M. P. G., Wagner, S. A., Waha, A., Walker, L. C., Walters, R. J., Wang-Gohrke, S., Weber, B. H. F., Weichert, W., Wieland, K., Wiesmüller, L., Witzel, I., Wöckel, A., Woodward, E. R., Zachariae, S., Zampiga, V., Zeder-Göß, C., KConFab Investigators, Lázaro, C., De Nicolo, A., Radice, P., Engel, C., Schmutzler, R. K., Goldgar, D. E. & Spurdle, A. B., Sep 2019, In : Human Mutation. 40, 9, p. 1557-1578 22 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Virulence
Neoplasm Genes
Adenosine Monophosphate
Computational Biology
Calibration

Mitochondrial Disease Caused by a Novel Homozygous Mutation (Gly106del) in the SCO1 Gene

Brix, N., Jensen, J. M., Pedersen, I. S., Ernst, A., Frost, S., Bogaard, P., Petersen, M. B. & Bender, L., 26 Jul 2019, In : Neonatology. 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Mitochondrial Diseases
Muscle Hypotonia
Brain Diseases
Acidosis
Early Diagnosis

Når genomisk medicin bliver personlig

Nielsen, I. K., Krarup, H. B. & Pedersen, I. S., 1 Apr 2019, In : Ugeskrift for Laeger. 181, 7A, p. 688-693 6 p., V11180780.

Research output: Contribution to journalJournal articleResearchpeer-review

Genome
Exome
Genetic Counseling
Genetic Testing
Germ Cells

Pancreas-specific plasma amylase for assessment and diagnosis of chronic pancreatitis: New insights on an old topic

Olesen, S. S., Krarup, H., Poulsen, J. L., Christensen, J. H., Sheel, A. R. G., Sutton, R., Greenhalf, W., Halloran, C. & Drewes, A. M., Aug 2019, In : United European Gastroenterology Journal. 7, 7, p. 955–964 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Chronic Pancreatitis
Amylases
Pancreas
Exocrine Pancreatic Insufficiency
ROC Curve

Præimplantationsgenetisk testning for aneuploidi

Translated title of the contribution: Preimplantation genetic testing for aneuploidyHolmqvist, V., Roos, L. K. S., Kjartansdottir, K. R., Dunø, M., Hnida, C., Pedersen, I. S., Ernst, A., Toft, C. L. F., Diemer, T., Ingerslev, H. J., Pinborg, A. & Løssl, K., 13 May 2019, In : Ugeskrift for Laeger. 181, 4 p., V12180849.

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic Testing
Aneuploidy
Birth Rate
Embryo Transfer
Live Birth

Single-Base Resolution Analysis of DNA Methylation in Fibromyalgia Women Compared with Their Healthy Sisters

Gerra, M. C., Pedersen, I. S., Carnevali, D., González-Villar, A., Triñanes, Y., Pidal-Miranda, M., Arendt-Nielsen, L. & Carrillo-de-la-Peña, M. T., 2019, In : Clinical and Experimental Rheumatology. 37, 1, Suppl. 116, p. S130 O-4.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Single-Base Resolution Analysis of DNA Methylation in Fibromyalgia Women Compared with Their Healthy Sisters

Gerra, M. C., Pedersen, I. S., Carnevali, D., González-Villar, A., Triñanes, Y., Pidal-Miranda, M., Arendt-Nielsen, L. & Carrillo-de-la-Peña, M. T., Apr 2019.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

Targeted single base resolution analysis of DNA methylation in fibromyalgia women compared with their healthy sisters

Gerra, M. C., Pedersen, I. S., Carnevali, D., Manfredini, M., Donnini, C., González-Villar, A., Triñanes, Y., Pidal-Miranda, M., Arendt-Nielsen, L. & Carrillo-de-la-Peña, M. T., 2019.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

1 Citation (Scopus)

T-cell and B-cell perturbations are similar in ART-naive HIV-1 and HIV-1/2 dually infected patients

Bissau HIV Cohort study group, Jun 2019, In : AIDS. 33, 7, p. 1143-1153 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

HIV-2
HIV-1
B-Lymphocytes
T-Lymphocytes
HIV Infections
1 Citation (Scopus)

T-cell and B-cell perturbations identify distinct differences in HIV-2 compared with HIV-1-induced immunodeficiency

Hønge, B. L., Petersen, M. S., Jespersen, S., Medina, C., Té, D. D. S., Kjerulff, B., Engell-Sørensen, T., Madsen, T., Laursen, A. L., Wejse, C., Krarup, H., Møller, B. K., Erikstrup, C. & Bissau HIV Cohort study group, Jun 2019, In : AIDS. 33, 7, p. 1131-1141 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

HIV-2
HIV-1
B-Lymphocytes
T-Lymphocytes
HIV
2018

10-year all-cause mortality among Greenlanders with frequent chronic Hepatitis B infection

Rex, K. F., Andersen, S. & Krarup, H., 2018, p. 2. 1 p.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

Open Access
2 Citations (Scopus)

A Danish national effort of BRCA1/2 variant classification

Pedersen, I. S., Schmidt, A. Y., Bertelsen, B., Ernst, A., Andersen, C. L. T., Kruse, T., Rossing, M. & Thomassen, M., 2018, In : Acta Oncologica. 57, 1, p. 159-162 3 p.

Research output: Contribution to journalLetterResearchpeer-review

Cell-free DNA promoter hypermethylation in plasma as biomarkers for pancreatic adenocarcinoma

Henriksen, S. D., Madsen, P. H., Larsen, A. C., Berg Johansen, M., Drewes, A., Pedersen, I. S., Krarup, H. & Thorlacius-Ussing, O., 2018, Danske Kræftforskningsdage: Abstract Book. p. 98 #90

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

Adenocarcinoma
Radiotherapy
Biomarkers
Tumor Burden
DNA
73 Downloads (Pure)

Chromium sequencing: the doors open for genomics of obligate plant pathogens

McTaggart, A. R., Duong, T. A., Le, V. Q., Shuey, L. S., Smidt, W., Naidoo, S., Wingfield, M. J. & Wingfield, B. D., 1 Nov 2018, In : BioTechniques. 65, 5, p. 253-257 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Chromium
Pathogens
Genomics
Genes
Plant Genome
2 Citations (Scopus)

Clinical and molecular characterization of BRCA-associated breast cancer: results from the DBCG

Soenderstrup, I. M. H., Laenkholm, A. V., Jensen, M. B., Eriksen, J. O., Gerdes, A. M., Hansen, T. V. O., Kruse, T. A., Larsen, M. J., Pedersen, I. S., Rossing, M., Thomassen, M. & Ejlertsen, B., 2018, In : Acta Oncologica. 57, 1, p. 95-101 7 p.

Research output: Contribution to journalConference article in JournalResearchpeer-review

Breast Neoplasms
Disease-Free Survival
Neoplasms
Mastectomy
Mutation

Colorectal cancer methylation markers

Thorlacius-Ussing, O., Ladefoged Rasmussen, S., Bygum Krarup, H. & Madsen, P. H., 2018, IPC No. C12Q 1/ 68 A I, Patent No. WO2018087129, 17 May 2018, Priority date 8 Nov 2016

Research output: Patent

Open Access
Methylation
Colorectal Neoplasms
Genes
3 Citations (Scopus)

Determination of anti-HCV and quantification of HCV-RNA and IP-10 from dried blood spots sent by regular mail

Neesgaard, B., Ruhwald, M., Krarup, H. B. & Weis, N., 2018, In : PLOS ONE. 13, 7, 13 p., e0201629.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Hepatitis C virus
Postal Service
Viruses
Hepacivirus
Blood
62 Downloads (Pure)

Differential effect of surgical manipulation on gene expression in normal breast tissue and breast tumor tissue

Pedersen, I. S., Thomassen, M., Tan, Q., Kruse, T., Thorlacius-Ussing, O., Garne, J. P. & Krarup, H. B., 16 Nov 2018, In : Molecular Medicine. 24, 1, p. 1-8 8 p., 57.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Breast
Breast Neoplasms
Gene Expression
Neoplasms
Ischemia
2 Citations (Scopus)

Direct acting antiviral treatment of chronic hepatitis C in Denmark: factors associated with and barriers to treatment initiation

Sølund, C., Hallager, S., Pedersen, M. S., Fahnøe, U., Ernst, A., Krarup, H. B., Røge, B. T., Christensen, P. B., Laursen, A. L., Gerstoft, J., Bélard, E., Madsen, L. G., Schønning, K., Pedersen, A. G., Bukh, J., Weis, N., DANHEP group, Krarup, H., Hansen, J. B. & Mygind, L., 2018, In : Scandinavian Journal of Gastroenterology. 53, 7, p. 849-856 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Chronic Hepatitis C
Denmark
Antiviral Agents
Therapeutics
Treatment Failure
110 Downloads (Pure)

First reported adult patient with TARP syndrome: A case report

Højland, A. T., Lolas, I., Okkels, H., Lautrup, C. K., Diness, B. R., Petersen, M. B. & Nielsen, I. K., Dec 2018, In : American Journal of Medical Genetics. Part A. 176, 12, p. 2915-2918 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Pierre Robin Syndrome
Nose
Intellectual Disability
Micrognathism
Siblings
3 Citations (Scopus)

Four weeks of ledipasvir/sofosbuvir and ribavirin with or without pegylated interferon for chronic hepatitis C in non-cirrhotic people who inject drugs: A randomized trial

Øvrehus, A. L. H., Krarup, H., Birkemose, I., Holm, D. K., Mössner, B., Ernst, A. & Christensen, P. B., 2018, In : Journal of Hepatology. 68, 4, p. 840-842 3 p.

Research output: Contribution to journalComment/debateResearchpeer-review

3 Citations (Scopus)
87 Downloads (Pure)

Full in-frame exon 3 skipping of BRCA2 confers high risk of breast and/or ovarian cancer

Caputo, S. M., Léone, M., Damiola, F., Ehlen, A., Carreira, A., Gaidrat, P., Martins, A., Brandão, R. D., Peixoto, A., Vega, A., Houdayer, C., Delnatte, C., Bronner, M., Muller, D., Castera, L., Guillaud-Bataille, M., Pedersen, I. S., Uhrhammer, N., Demontety, S., Tubeuf, H. & 16 others, Castelain, G., French COVAR group collaborators, Jensen, U. B., Petitalot, A., Krieger, S., Lefol, C., Moncoutier, V., Boutry-Kryza, N., Nielsen, H. R., Sinilnikova, O., Stoppa-Lyonnet, D., Spurdle, A. B., Teixeira, M. R., Coulet, F., Thomassen, M. & Rouleau, E., 1 Apr 2018, In : Oncotarget. 9, 25, p. 17334-17348 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Ovarian Neoplasms
Exons
Breast Neoplasms
BRCA2 Gene
France

Genetic Testing and Clinical Management Practices for Variants in Non-BRCA1/2 Breast (and Breast/Ovarian) Cancer Susceptibility Genes: An International Survey by the Evidence-Based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) Clinical Working Group

Nielsen, S. M., Eccles, D. M., Romero, I. L., Al-Mulla, F., Balmaña, J., Biancolella, M., Blok, R., Caligo, M. A., Calvello, M., Capone, G. L., Cavalli, P., Chan, T. L. C., Claes, K. B. M., Cortesi, L., Couch, F. J., de la Hoya, M., De Toffol, S., Diez, O., Domchek, S. M., Eeles, R. & 45 others, Efremidis, A., Fostira, F., Goldgar, D., Hadjisavvas, A., Hansen, T. V. O., Hirasawa, A., Houdayer, C., Kleiblova, P., Krieger, S., Lázaro, C., Loizidou, M., Manoukian, S., Mensenkamp, A. R., Moghadasi, S., Monteiro, A. N., Mori, L., Morrow, A., Naldi, N., Nielsen, H. R., Olopade, O. I., Pachter, N. S., Palmero, E. I., Pedersen, I. S., Piane, M., Puzzo, M., Robson, M., Rossing, M., Sini, M. C., Solano, A., Soukupova, J., Tedaldi, G., Teixeira, M., Thomassen, M., Tibiletti, M. G., Toland, A., Törngren, T., Vaccari, E., Varesco, L., Vega, A., Wallis, Y., Wappenschmidt, B., Weitzel, J., Spurdle, A. B., De Nicolo, A. & Gómez-García, E. B., 26 Oct 2018, In : JCO Precision Oncology.

Research output: Contribution to journalJournal articleResearchpeer-review

1 Citation (Scopus)

Hepatocellular carcinoma in patients with chronic hepatitis C and cirrhosis in Denmark: a nationwide cohort study

Hallager, S., Ladelund, S., S. Kjaer, M., Madsen, L. G., Belard, E., Laursen, A. L., Gerstoft, J., Røge, B. T., Grønbæk, K. E., Krarup, H. B., Christensen, P. B. & Weis, N., 2018, In : Journal of Viral Hepatitis. 25, 1, p. 47-55 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Chronic Hepatitis C
Denmark
Hepatocellular Carcinoma
Fibrosis
Cohort Studies
65 Downloads (Pure)

High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals

Pihl, A. F., Offersgaard, A. F., Mathiesen, C. K., Prentoe, J., Fahnøe, U., Krarup, H., Bukh, J. & Gottwein, J. M., Nov 2018, In : Scientific Reports. 8, 1, 13 p., 17505.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Bioreactors
Hepacivirus
Antiviral Agents
Cell Count
Cell Culture Techniques

HIV, TB, inflammation and other correlates of serum phosphate: A cross-sectional study

Friis, H., Range, N. S., Changalucha, J., PrayGod, G., Jeremiah, K., Faurholt-Jepsen, D., Krarup, H. B., Andersen, A. B., Kæstel, P. & Filteau, S., 2018, In : Clinical Nutrition ESPEN. 27, p. 38-43 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Tuberculosis
Cross-Sectional Studies
Phosphates
HIV
Inflammation
6 Citations (Scopus)
74 Downloads (Pure)

Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe

Colagrossi, L., Hermans, L. E., Salpini, R., Di Carlo, D., Pas, S. D., Alvarez, M., Ben-Ari, Z., Boland, G., Bruzzone, B., Coppola, N., Seguin-Devaux, C., Dyda, T., Garcia, F., Kaiser, R., Köse, S., Krarup, H., Lazarevic, I., Lunar, M. M., Maylin, S., Micheli, V. & 20 others, Mor, O., Paraschiv, S., Paraskevis, D., Poljak, M., Puchhammer-Stöckl, E., Simon, F., Stanojevic, M., Stene-Johansen, K., Tihic, N., Trimoulet, P., Verheyen, J., Vince, A., Lepej, S. Z., Weis, N., Yalcinkaya, T., Boucher, C. A. B., Wensing, A. M. J., Perno, C. F., Svicher, V. & HEPVIR working group of the European Society for translational antiviral research (ESAR), 1 Jun 2018, In : BMC Infectious Diseases. 18, 1, p. 1-12 12 p., 251.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Terminator Codon
Hepatitis B Surface Antigens
Mutation
Infection
Pharmaceutical Preparations
42 Citations (Scopus)

Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations

Rebbeck, T. R., Friebel, T. M., Friedman, E., Hamann, U., Huo, D., Kwong, A., Olah, E., Olopade, O. I., Solano, A. R., Teo, S-H., Thomassen, M., Weitzel, J. N., Chan, T. L., Couch, F. J., Goldgar, D. E., Kruse, T. A., Palmero, E. I., Park, S. K., Torres, D., van Rensburg, E. J. & 225 others, McGuffog, L., Parsons, M. T., Leslie, G., Aalfs, C. M., Abugattas, J., Adlard, J., Agata, S., Aittomäki, K., Andrews, L., Andrulis, I. L., Arason, A., Arnold, N., Arun, B. K., Asseryanis, E., Auerbach, L., Azzollini, J., Balmaña, J., Barile, M., Barkardottir, R. B., Barrowdale, D., Benitez, J., Berger, A., Berger, R., Blanco, A. M., Blazer, K. R., Blok, M. J., Bonadona, V., Bonanni, B., Bradbury, A. R., Brewer, C., Buecher, B., Buys, S. S., Caldes, T., Caliebe, A., Caligo, M. A., Campbell, I., Caputo, S. M., Chiquette, J., Chung, W. K., Claes, K. B. M., Collée, J. M., Cook, J., Davidson, R., de la Hoya, M., De Leeneer, K., de Pauw, A., Delnatte, C., Diez, O., Ding, Y. C., Ditsch, N., Domchek, S. M., Dorfling, C. M., Velazquez, C., Dworniczak, B., Eason, J., Easton, D. F., Eeles, R., Ehrencrona, H., Ejlertsen, B., EMBRACE, Engel, C., Engert, S., Evans, D. G., Faivre, L., Feliubadaló, L., Ferrer, S. F., Foretova, L., Fowler, J., Frost, D., Galvão, H. C. R., Ganz, P. A., Garber, J., Gauthier-Villars, M., Gehrig, A., GEMO Study Collaborators, Gerdes, A-M., Gesta, P., Giannini, G., Giraud, S., Glendon, G., Godwin, A. K., Greene, M. H., Gronwald, J., Gutierrez‐Barrera, A., Hahnen, E., Hauke, J., HEBON, Henderson, A., Hentschel, J., Hogervorst, F. B. L., Honisch, E., Imyanitov, E. N., Isaacs, C., Izatt, L., Izquierdo, A., Jakubowska, A., James, P., Janavicius, R., Jensen, U. B., John, E. M., Vijai, J., Kaczmarek, K., Karlan, B. Y., Kast, K., KConFab Investigators, Kim, S-W., Konstantopoulou, I., Korach, J., Laitman, Y., Lasa, A., Lasset, C., Lázaro, C., Lee, A., Lee, M. H., Lester, J., Lesueur, F., Liljegren, A., Lindor, N. M., Longy, M., Loud, J. T., Lu, K. H., Lubinski, J., Machackova, E., Manoukian, S., Mari, V., Martínez-Bouzas, C., Matrai, Z., Mebirouk, N., Meijers‐Heijboer, H. E. J., Meindl, A., Mensenkamp, A., Mickys, U., Miller, A., Montagna, M., Moysich, K. B., Mulligan, A. M., Musinsky, J., Neuhausen, S. L., Nevanlinna, H., Ngeow, J., Nguyen, H. P., Niederacher, D., Nielsen, H. R., Nielsen, F. C., Nussbaum, R. L., Offit, K., Öfverholm, A., Ong, K-R., Osorio, A., Papi, L., Papp, J., Pasini, B., Pedersen, I. S., Peixoto, A., Peruga, N., Peterlongo, P., Pohl, E., Pradhan, N., Prajzendanc, K., Prieur, F., Pujol, P., Radice, P., Ramus, S. J., Rantala, J., Rashid, M. U., Rhiem, K., Robson, M., Rodriguez, G. C., Rogers, M. T., Rudaitis, V., Schmidt, A. Y., Schmutzler, R. K., Senter, L., Shah, P. D., Sharma, P., Side, L. E., Simard, J., Singer, C. F., Skytte, A-B., Slavin, T. P., Snape, K., Sobol, H., Southey, M. C., Steele, L., Steinemann, D., Sukiennicki, G., Sutter, C., Szabo, C. I., Tan, Y. Y., Teixeira, M. R., Terry, M. B., Teulé, A., Thomas, A., Thull, D. L., Tischkowitz, M., Tognazzo, S., Toland, A. E., Topka, S., Trainer, A. H., Tung, N., van Asperen, C. J., van der Hout, A. H., van der Kolk, L. E., van der Luijt, R. B., Van Heetvelde, M., Varesco, L., Varon-Mateeva, R., Vega, A., Villarreal‐Garza, C., von Wachenfeldt, A., Walker, L., Wang-Gohrke, S., Wappenschmidt, B., Weber, B. H. F., Yannoukakos, D., Yoon, S-Y., Zanzottera, C., Zidan, J., Zorn, K. K., Selkirk, C. G. H., Hulick, P. J., Chenevix-Trench, G., Spurdle, A. B., Antoniou, A. C. & Nathanson, K. L., May 2018, In : Human Mutation. 39, 5, p. 593-620 28 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Mutation
Population
Research Personnel
Germ-Line Mutation
Genetic Testing

Præimplantationsgenetisk Diagnostik

Ingerslev, H. J., Degn, B., Hnida, C., Diemer, T., Petersen, M. B., Olesen, T. N., Krarup, H. & Pedersen, I. S., 2018, In : Ugeskrift for Laeger. 180, p. 2-5 4 p., V09170692.

Research output: Contribution to journalJournal articleResearchpeer-review

1 Citation (Scopus)
43 Downloads (Pure)

Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea-Bissau: a cross-sectional study

Grønborg, H. L., Jespersen, S., Egedal, J. H., Correia, F. G., Medina, C., Krarup, H., Hønge, B. L., Wejse, C. & Bissau HIV Cohort study group, Aug 2018, In : Tropical Medicine & International Health. 23, 8, p. 896–904 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Guinea-Bissau
Coinfection
Cross-Sectional Studies
HIV
Viremia
3 Citations (Scopus)
9 Downloads (Pure)

Protease Inhibitors or NNRTIs as First-Line HIV-1 Treatment in West Africa (PIONA): A Randomized Controlled Trial

Jespersen, S., Hønge, B. L., Krarup, H., Medstrand, P., Sørensen, A., Medina, C., da Silva Té, D., Correira, F. G., Erikstrup, C., Østergaard, L., Wejse, C., Laursen, A. L. & Bissau HIV Cohort study group, 1 Nov 2018, In : Journal of Acquired Immune Deficiency Syndromes. 79, 3, p. 386–393 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Western Africa
Protease Inhibitors
HIV-1
Randomized Controlled Trials
Guinea-Bissau
16 Citations (Scopus)

The BRCA1 c. 5096G>A p.Arg1699Gln (R1699Q) intermediate risk variant: breast and ovarian cancer risk estimation and recommendations for clinical management from the ENIGMA consortium

Moghadasi, S., Meeks, H. D., Vreeswijk, M. P., Janssen, L. A., Borg, Å., Ehrencrona, H., Paulsson-Karlsson, Y., Wappenschmidt, B., Engel, C., Gehrig, A., Arnold, N., Hansen, T. V. O., Thomassen, M., Jensen, U. B., Kruse, T. A., Ejlertsen, B., Gerdes, A-M., Pedersen, I. S., Caputo, S. M., Couch, F. & 20 others, Hallberg, E. J., van den Ouweland, A. M., Collée, J. M., Teugels, E., Adank, M. A., van der Luijt, R. B., Mensenkamp, A. R., Oosterwijk, J. C., Blok, M. J., Janin, N., Claes, K. B., Tucker, K., Viassolo, V., Toland, A. E., Eccles, D. E., Devilee, P., Van Asperen, C. J., Spurdle, A. B., Goldgar, D. E. & Garcia, E. B. G., 2018, In : Journal of Medical Genetics. 55, p. 15-20 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Ovarian Neoplasms
Alleles
Breast Neoplasms
Neoplasms
Ovariectomy
10 Citations (Scopus)

The challenge of discriminating between HIV-1, HIV-2 and HIV-1/2 dual infections

Hønge, B. L., Jespersen, S., Medina, C., Té, D. S., da Silva, Z. J., Christiansen, M., Kjerulff, B., Laursen, A. L., Wejse, C., Krarup, H., Erikstrup, C. & Bissau HIV Cohort study group, Jul 2018, In : HIV Medicine. 19, 6, p. 403-410 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

HIV-2
HIV-1
Infection
HIV
RNA
7 Citations (Scopus)

The influence of human leukocyte antigen-types on disease progression among HIV-2 infected patients in Guinea-Bissau

Thomsen, D., Erikstrup, C., Jespersen, S., Medina, C., Té, D. D. S., Correira, F. G., Christiansen, M., Wejse, C., Krarup, H., Møller, B. K., Hønge, B. L. & Bissau HIV Cohort study group, 27 Mar 2018, In : AIDS. 32, 6, p. 721-728 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Guinea-Bissau
HIV-2
HLA Antigens
Disease Progression
Viral Load
3 Citations (Scopus)

The prognostic efficacy of cell-free DNA hypermethylation in colorectal cancer

Rasmussen, S. L., Krarup, H. B., Sunesen, K. G., Johansen, M. B., Stender, M. T., Pedersen, I. S., Madsen, P. H. & Thorlacius-Ussing, O., 23 Jan 2018, In : OncoTarget. 9, 6, p. 7010-7022 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Genetic Promoter Regions
Colorectal Neoplasms
DNA
Neoplasm Metastasis
Survival
2 Citations (Scopus)
78 Downloads (Pure)

Treatment of chronic hepatitis B in sub-Saharan Africa: 1-year results of a pilot program in Ethiopia

Desalegn, H., Aberra, H., Berhe, N., Mekasha, B., Stene-Johansen, K., Krarup, H., Pereira, A. P., Gundersen, S. G. & Johannessen, A., 17 Dec 2018, In : BMC Medicine. 16, 1, 10 p., 234.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Ethiopia
Africa South of the Sahara
Chronic Hepatitis B
Tenofovir
Therapeutics
2017

A Danish nationwide questionnaire study of hepatitis B virus screening before immunosuppressive therapy

Bunyoz, K. I., Krarup, H. & Weis, N., 2017, In : Danish Medical Journal. 64, 3, 4 p., A5341.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
9 Citations (Scopus)

Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3

Hamdi, Y., Soucy, P., Kuchenbaeker, K. B., Pastinen, T., Droit, A., Lemaçon, A., Adlard, J., Aittomäki, K., Andrulis, I. L., Arason, A., Arnold, N., Arun, B. K., Azzollini, J., Bane, A., Barjhoux, L., Barrowdale, D., Benitez, J., Berthet, P., Blok, M. J., Bobolis, K. & 31 others, Bonadona, V., Bonanni, B., Bradbury, A. R., Brewer, C., Buecher, B., Buys, S. S., Caligo, M. A., Chiquette, J., Chung, W. K., Claes, K. B. M., Daly, M. B., Damiola, F., Davidson, R., De la Hoya, M., De Leeneer, K., Diez, O., Ding, Y. C., Dolcetti, R., Domchek, S. M., Dorfling, C. M., Eccles, D., Eeles, R., Einbeigi, Z., Ejlertsen, B., Engel, C., Gareth Evans, D., Feliubadalo, L., Foretova, L., Fostira, F., Pedersen, I. S. & EMBRACE, 2017, In : Breast Cancer Research and Treatment. 161, 1, p. 117-134 18 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Heterozygote
Single Nucleotide Polymorphism
Breast Neoplasms
Mutation
Estrogen Receptors
5 Citations (Scopus)
106 Downloads (Pure)

Cell-free DNA promoter hypermethylation in plasma as a predictive marker for survival of patients with pancreatic adenocarcinoma

Henriksen, S. D., Madsen, P. H., Larsen, A. C., Berg Johansen, M., Pedersen, I. S., Krarup, H. & Thorlacius-Ussing, O., 2017, In : OncoTarget. 8, 55, p. 93942-93956 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Clinical outcomes of female breast cancer according to BRCA mutation status

Cronin-Fenton, D. P., Kjærsgaard, A., Nørgaard, M., Pedersen, I. S., Thomassen, M., Kaye, J. A., Gutierrez, L., Telford, C., Lewis, J., Tyczynski, J. E. & Sørensen, H. T., 2017, In : Cancer Epidemiology. 49, p. 128-137 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Breast Neoplasms
Mutation
Germ-Line Mutation
Denmark
Survival
6 Citations (Scopus)

Common genetic variants are associated with lower serum 25-hydroxyvitamin D concentrations across the year among children at northern latitudes

Petersen, R. A., Larsen, L. H., Damsgaard, C. T., Sørensen, L. B., Hjorth, M. F., Andersen, R., Tetens, I., Krarup, H., Ritz, C., Astrup, A., Michaelsen, K. F. & Mølgaard, C., 2017, In : British Journal of Nutrition. 117, 6, p. 829-838 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Serum
Alleles
Vitamin D
Single Nucleotide Polymorphism
Genotype
2 Citations (Scopus)
Exome
Nonsense Codon
Mutation
Blepharophimosis
Genetic Databases

Four weeks of Ledipasvir/Sofosbuvir plus Ribavirin with or without interferon gives very high and sustained cure rates in difficult to reach but easy to treat injecting drug users with chronic hepatitis C: final results of the 4WIDUC study: Journal of Hepatology

Øvrehus, A. L. H., Krarup, H., Birkemose, I., Mössner, B. & Christensen, P. B., 2017, In : Journal of Hepatology. 66, 1, p. S287-S287 THU-225.

Research output: Contribution to journalConference abstract in journalResearchpeer-review