Projects per year
Organisation profile
Organisation profile
Head of research group: Torben Moos
Who we are?
The group encompasses these members: Prof. Torben Moos, Assoc. Prof. Ove Wiborg, Assoc. Prof. Louiza Bohn Thomsen, Asst. Prof. Annette Burkhart, Asst. Prof. Maj Schneider Thomsen, Postdoc Lisa Juul Routhe, PhD Student Eva Hede Olsen, PhD Student Steinunn Sara Helgudottir, PhD Student Charlotte L.M. Rasmussen, PhD Student Amanda Clement, Technician Merete Fredsgaard and Technician Hanne Krone Nielsen.
Our research – what we do?
We focus on understanding the biology of the brain’s vasculature both in health and pathology. We also focus on the restraints of the brain’s vasculature for drug delivery. We develop strategies for delivery of drugs to the brain using, e.g. gene therapy, therapeutic nanoparticles and antibodies intended for treatment of patients with brain diseases like Alzheimer’s disease, Niemann-Picks disease and brain cancer. Our experimental models are primarily based on rodent in vivo models and in vitro primary cell culture models.
How does our research contribute to societal health challenges?
We contribute with basic knowledge about the anatomy and physiology of the brain vasculature, which is useful for increasing the knowledge about the development and progression of brain diseases like Alzheimer’s disease, hemorrhage and brain cancer. We also contribute to optimizing existing treatment and developing new treatment strategies for multiple types of brain diseases.
Who are our key collaborators?
We collaborate with leading scientists from University of Copenhagen, Aarhus University, University of Southern Denmark, The Technical University of Denmark (DTU), Uppsala University, University of Hamburg and other research groups at Aalborg University. Furthermore, we collaborate with leading national and international pharmaceutical companies.
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Collaborations from the last five years
Profiles
Projects
- 2 Finished
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Targeteret terapi i den hypoksiske og inflammerede blod-hjerne barriere
Helgudottir, S. S. (PI), Schneider Thomsen, M. (Supervisor), Moos, T. (Supervisor) & Johnsen, K. B. (Supervisor)
Aase og Ejnar Danielsens fond, Kong Christian den Tiendes Fond
01/03/2019 → 01/03/2021
Project: Research
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Epigenetisk regulering af ferroportin i den neurovaskulære enhed
Helgudottir, S. S. (PI), Lichota, J. (Supervisor), Routhe, L. G. (CoI), Moos, T. (Supervisor), Jønsson, K. (CoI), Larsen, A. B. (PI) & Pedersen, I. S. (CoI)
01/12/2017 → 01/11/2019
Project: Research
Research output
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Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2
Rasmussen, C. L. M., Frederiksen, S. F., Heegaard, C. W., Thomsen, M. S., Hede, E., Laczek, B., Körbelin, J., Wüstner, D., Thomsen, L. B., Schwaninger, M., Jensen, O. N., Moos, T. & Burkhart, A., 31 Jan 2025, In: Fluids and Barriers of the CNS. 22, 1, 13.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile -
Remodeling of the brain angioarchitecture in experimental chronic neurodegeneration
Thomsen, M. S., Kostrikov, S., Routhe, L. G., Johnsen, K. B., Helgudóttir, S. S., Gudbergsson, J. M., Andresen, T. L. & Moos, T., Jan 2025, In: Neurobiology of Disease. 204, 106761.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Downloads (Pure) -
Activation of glial cells induces proinflammatory properties in brain capillary endothelial cells in vitro
Burkhart, A., Helgudóttir, S. S., Mahamed, Y. A., Fruergaard, M. B., Holm-Jacobsen, J. N., Haraldsdóttir, H., Dahl, S. E., Pretzmann, F., Routhe, L. G., Lambertsen, K., Moos, T. & Thomsen, M. S., 4 Nov 2024, In: Scientific Reports. 14, 1, 26580.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)2 Downloads (Pure)
Datasets
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Additional file 1 of Intravenous iron isomaltoside versus oral iron supplementation for treatment of iron deficiency in pregnancy: protocol for a randomised, comparative, open-label trial
Pinborg, A. (Creator), Moos, T. (Creator), Holm, C. (Creator), Hansen, R. (Creator), Thomsen, L. L. (Creator) & Markova, V. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.12864674.v1, https://doi.org/10.6084%2Fm9.figshare.12864674.v1
Dataset
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Intravenous iron isomaltoside versus oral iron supplementation for treatment of iron deficiency in pregnancy: protocol for a randomised, comparative, open-label trial
Markova, V. (Creator), Hansen, R. (Creator), Thomsen, L. L. (Creator), Pinborg, A. (Creator), Moos, T. (Creator) & Holm, C. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.c.5102231.v1, https://springernature.figshare.com/collections/Intravenous_iron_isomaltoside_versus_oral_iron_supplementation_for_treatment_of_iron_deficiency_in_pregnancy_protocol_for_a_randomised_comparative_open-label_trial/5102231/1
Dataset
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Intravenous iron isomaltoside versus oral iron supplementation for treatment of iron deficiency in pregnancy: protocol for a randomised, comparative, open-label trial
Markova, V. (Creator), Hansen, R. (Creator), Thomsen, L. L. (Creator), Pinborg, A. (Creator), Moos, T. (Creator) & Holm, C. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.c.5102231, https://springernature.figshare.com/collections/Intravenous_iron_isomaltoside_versus_oral_iron_supplementation_for_treatment_of_iron_deficiency_in_pregnancy_protocol_for_a_randomised_comparative_open-label_trial/5102231
Dataset
Press/Media
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Disse sygdomme kan du få fra dit kæledyr
22/12/2024
1 item of Media coverage
Press/Media: Press / Media
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Hold dig for næsen: Mikroplast trænger nu ind i hjernen
19/09/2024 → 21/09/2024
3 items of Media coverage
Press/Media: Press / Media
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Forskere har fundet »dramatiske« mængder mikroplast i hjernevæv
23/08/2024 → 28/08/2024
2 items of Media coverage
Press/Media: Press / Media