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2020

An evaluation of different Cripto-1 antibodies and their variable results

Gudbergsson, J. M. & Duroux, M., Jan 2020, In : Journal of Cellular Biochemistry. 121, 1, p. 545-556 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Astrocytic expression of ZIP14 (SLC39A14) is part of the inflammatory reaction in chronic neurodegeneration with iron overload

Routhe, L. J., Andersen, I. K., Hauerslev, L. V., Issa, I. I., Moos, T. & Thomsen, M. S., 2020, (Accepted/In press) In : Glia.

Research output: Contribution to journalJournal article

Gene therapy to the blood-brain barrier with resulting protein secretion as a strategy for treatment of Niemann Picks type C2 disease

Hede, E., Christiansen, C. B., Heegaard, C. W., Moos, T. & Burkhart, A., 19 Feb 2020, In : Journal of Neurochemistry. e14982.

Research output: Contribution to journalJournal articleResearchpeer-review

2019

A tumorsphere model of glioblastoma multiforme with intratumoral heterogeneity for quantitative analysis of cellular migration and drug response

Gudbergsson, J. M., Kostrikov, S., Johnsen, K. B., Fliedner, F. P., Stolberg, C. B., Humle, N., Hansen, A. E., Kristensen, B. W., Christiansen, G., Kjær, A., Andresen, T. L. & Duroux, M., 1 Jun 2019, In : Experimental Cell Research. 379, 1, p. 73-82 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

4 Citations (Scopus)

DNA methylation regulates CHRNA7 transcription and can be modulated by valproate

Dyrvig, M., Mikkelsen, J. D. & Lichota, J., 21 Jun 2019, In : Neuroscience Letters. 704, p. 145-152 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Hepcidin mediates transcriptional changes in ferroportin mRNA in differentiated neuronal-like PC12 cells subjected to iron challenge

Helgudottir, S. S., Lichota, J., Burkhart, A. & Moos, T., Apr 2019, In : Molecular Neurobiology. 56, 4, p. 2362-2374 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

1 Citation (Scopus)

Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo

Johnsen, K. B., Bak, M., Melander, F., Thomsen, M. S., Burkhart, A., Kempen, P. J., Andresen, T. L. & Moos, T., 10 Feb 2019, In : Journal of Controlled Release. 295, p. 237-249 13 p.

Research output: Contribution to journalJournal article

16 Citations (Scopus)
2018

Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles

Johnsen, K. B., Bak, M., Kempen, P. J., Melander, F., Burkhart, A., Thomsen, M. S., Nielsen, M. S., Moos, T. & Andresen, T. L., 2018, In : Theranostics. 8, 12, p. 3416-3436 21 p.

Research output: Contribution to journalJournal article

Open Access
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16 Citations (Scopus)
599 Downloads (Pure)

Intravenous iron isomaltoside improves hemoglobin concentration and iron stores in female iron-deficient blood donors: a randomized double-blind placebo-controlled clinical trial

Gybel-Brask, M., Seeberg, J., Thomsen, L. L. & Johansson, P. I., 1 Apr 2018, In : Transfusion. 58, 4, p. 974-981 8 p.

Research output: Contribution to journalJournal article

Open Access
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5 Citations (Scopus)
31 Downloads (Pure)

The endo-lysosomal system of brain endothelial cells is influenced by astrocytes in vitro

Toth, A. E., Siupka, P., P Augustine, T. J., Venø, S. T., Thomsen, L. B., Moos, T., Lohi, H. T., Madsen, P., Lykke-Hartmann, K. & Nielsen, M. S., Nov 2018, In : Molecular Neurobiology. 55, 11, p. 8522-8537 16 p.

Research output: Contribution to journalJournal articleResearchpeer-review

4 Citations (Scopus)
2017

Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells

Siupka, P., Hersom, M. N. S., Lykke-Hartmann, K., Johnsen, K. B., Thomsen, L. B., Andresen, T. L., Moos, T., Abbott, N. J., Brodin, B. & Nielsen, M. S., 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 7, p. 2598–2613

Research output: Contribution to journalJournal article

11 Citations (Scopus)

Characterization of ATP7A missense mutants suggests a correlation between intracellular trafficking and severity of Menkes disease

Skjørringe, T., Pedersen, P. A., Thorborg, S. S., Nissen, P., Gourdon, P. & Møller, L. B., 1 Dec 2017, In : Scientific Reports. 7, 1, 18 p., 757.

Research output: Contribution to journalJournal article

Open Access
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4 Citations (Scopus)
128 Downloads (Pure)

DNA methylation analysis of BRD1 promoter regions and the schizophrenia rs138880 risk allele

Dyrvig, M., Qvist, P., Lichota, J., Larsen, K., Nyegaard, M., Børglum, A. D. & Christensen, J. H., 2017, In : PLOS ONE. 12, 1, 19 p., e0170121.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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6 Citations (Scopus)
204 Downloads (Pure)
20 Citations (Scopus)

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma

Johnsen, K. B., Burkhart, A., Melander, F., Kempen, P. J., Vejlebo, J. B., Siupka, P., Nielsen, M. S., Andresen, T. L. & Moos, T., 1 Dec 2017, In : Scientific Reports. 7, 13 p., 10396.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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45 Citations (Scopus)
95 Downloads (Pure)

The schizophrenia-associated BRD1 gene regulates behavior, neurotransmission, and expression of schizophrenia risk enriched gene sets in mice

Qvist, P., Christensen, J. H., Vardya, I., Rajkumar, A. P., Mørk, A., Paternoster, V., Füchtbauer, E-M., Pallesen, J., Fryland, T., Dyrvig, M., Hauberg, M. E., Lundsberg, B., Fejgin, K., Nyegaard, M., Jensen, K., Nyengaard, J. R., Mors, O., Didriksen, M. & Børglum, A. D., 2017, In : Biological Psychiatry. 82, 1, p. 62-76

Research output: Contribution to journalJournal articleResearchpeer-review

5 Citations (Scopus)
3 Citations (Scopus)
2016

Evaluation of electroporation-induced adverse effects on adipose-derived stem cell exosomes

Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Christiansen, G., Gurevich, L., Moos, T. & Duroux, M., 2016, In : Cytotechnology. 68, 5, p. 2125–2138

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
24 Citations (Scopus)

Expression of iron-related proteins at the neurovascular unit supports reduction and reoxidation of iron for transport through the blood-brain barrier

Burkhart, A., Skjørringe, T., Johnsen, K. B., Siupka, P., Thomsen, L. B., Nielsen, M. S., Thomsen, L. L. & Moos, T., 2016, In : Molecular Neurobiology. 53, 10, p. 7237-7253

Research output: Contribution to journalJournal article

32 Citations (Scopus)

Geographical variation in antipsychotic drug use in elderly patients with dementia: a nationwide study

Zakarias, J. K., Jensen-Dahm, C., Nørgaard, A., Stevnsborg, L., Gasse, C., Andersen, B. G., Søren, J., Waldorff, F. B., Moos, T. & Waldemar, G., 2016, In : Journal of Alzheimer's Disease. 54, 3, p. 1183-1192

Research output: Contribution to journalJournal article

Open Access
File
6 Citations (Scopus)
191 Downloads (Pure)

Metal-dependent regulation of ATP7A and ATP7B in fibroblast cultures

Lenartowicz, M., Moos, T., Ogórek, M., Jensen, T. G. & Møller, L. B., 2016, In : Frontiers in Molecular Neuroscience. 9, 68.

Research output: Contribution to journalJournal article

Open Access
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168 Downloads (Pure)

On the prospect of clinical utilization of microRNAs as biomarkers or treatment of chronic pain

Andersen, H. H., Johnsen, K. B. & Arendt-Nielsen, L., 2016, In : Experimental Neurology. 284, Part A, p. 63-66

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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1 Citation (Scopus)
121 Downloads (Pure)
2015

A triple culture model of the blood-brain barrier using porcine brain endothelial cells, astrocytes and pericytes

Thomsen, L. B., Burkhart, A. & Moos, T., 2015, In : PLOS ONE. 10, 8, 16 p., e0134765.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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58 Citations (Scopus)
270 Downloads (Pure)
368 Downloads (Pure)
Open Access
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58 Citations (Scopus)
263 Downloads (Pure)

Epigenetic regulation of Dnmt3a and Arc gene expression after electroconvulsive stimulation in the rat

Dyrvig, M., Gøtzsche, C. R., Woldbye, D. P. D. & Lichota, J., 2015, In : Molecular and Cellular Neuroscience. 67, p. 137-143

Research output: Contribution to journalJournal articleResearchpeer-review

12 Citations (Scopus)

Handling iron in restorative neuroscience

Routhe, L. J. & Moos, T., 2015, In : Neural Regeneration Research. 10, 10, p. 1558-1559

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
3 Citations (Scopus)

Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons

Thomsen, M. S., Andersen, M. V., Christoffersen, P. R., Jensen, M. D., Lichota, J. & Moos, T., 2015, In : Neurobiology of Disease. 81, p. 108-118

Research output: Contribution to journalJournal article

30 Citations (Scopus)

Targeted drug delivery to the brain using magnetic nanoparticles

Thomsen, L. B., Thomsen, M. S. & Moos, T., 2015, In : Therapeutic Delivery. 6, 10, p. 1145-1155

Research output: Contribution to journalJournal article

31 Citations (Scopus)
Open Access
File
24 Citations (Scopus)
287 Downloads (Pure)
2014

Accessing targeted nanoparticles to the brain: the vascular route

Burkhart, A., Azizi, M., Thomsen, M. S., Thomsen, L. B. & Moos, T., 2014, In : Current Medicinal Chemistry. 21, 36, p. 4092-4099

Research output: Contribution to journalJournal articleResearchpeer-review

8 Citations (Scopus)

Cripto-1 expression in glioblastoma multiforme

Pilgaard, L., Mortensen, J. H., Henriksen, M., Olesen, P., Sørensen, P., Laursen, R. J., Vyberg, M., Agger, R., Zachar, V., Moos, T. & Duroux, M., 2014, In : Brain Pathology. 24, 4, p. 360–370

Research output: Contribution to journalJournal articleResearchpeer-review

17 Citations (Scopus)

Cripto-1 Expression in Glioblastoma Multiforme

Pilgaard, L., Mortensen, J. H., Henriksen, M., Olesen, P., Sorensen, P., Laursen, R., Vyberg, M., Agger, R., Zachar, V., Moos, T. & Duroux, M., 2014, In : Brain Pathology.

Research output: Contribution to journalJournal articleResearchpeer-review

Temporal gene expression profile after acute electroconvulsive stimulation in the rat

Johannesen, M. D., Christiansen, S. H., Woldbye, D. P. D. & Lichota, J., 2014, In : Gene. 539, 1, p. 8-14

Research output: Contribution to journalJournal articleResearchpeer-review

24 Citations (Scopus)
2013

Development of a Novel Lipophilic, Magnetic Nanoparticle for in Vivo Drug Delivery

Linemann, T., Thomsen, L. B., du Jardin, K. G., Laursen, J. C., Jensen, J. B., Lichota, J. & Moos, T., 2013, In : Pharmaceutics. 5, 2, p. 246-260

Research output: Contribution to journalJournal articleResearchpeer-review

11 Citations (Scopus)

Targeted antiepidermal growth factor receptor (Cetuximab) immunoliposomes enhance cellular uptake in vitro and exhibit increased accumulation in an intracranial model of glioblastoma multiforme

Mortensen, J. H., Jeppesen, M., Pilgaard, L., Agger, R., Duroux, M., Zachar, V. & Moos, T., 2013, In : Journal of Drug Delivery. 2013, p. Article No. 209205 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Uptake and transport of superparamagnetic iron oxide nanoparticles through human brain capillary endothelial cells

Thomsen, L. B., Linemann, T., Pondman, K. M., Lichota, J., Kim, K. S., Pieters, R. J., Visser, G. M. & Moos, T., 2013, In : ACS Chemical Neuroscience. 4, 10, p. 1352-1360

Research output: Contribution to journalJournal articleResearchpeer-review

44 Citations (Scopus)
2012

Brain delivery systems via mechanism independent of receptor-mediated endocytosis and adsorptive-mediated endocytosis

Thomsen, L. B., Lichota, J., Eskehave, T. N., Linemann, T., Mortensen, J. H., du Jardin, K. G. & Moos, T., 2012, In : Current Pharmaceutical Biotechnology. 13, 12, p. 2349-2354

Research output: Contribution to journalJournal articleResearchpeer-review

14 Citations (Scopus)

Chronic vitamin C deficiency does not accelerate oxidative stress in ageing brains of guinea pigs

Tveden-Nyborg, P., Hasselholt, S., Miyashita, N., Moos, T., Poulsen, H. E. & Lykkesfeldt, J., 2012, In : Basic & Clinical Pharmacology & Toxicology. 110, 6, p. 524-529

Research output: Contribution to journalJournal articleResearchpeer-review

14 Citations (Scopus)

Epigenetic regulation of Arc and c-Fos in the hippocampus after acute electroconvulsive stimulation in the rat

Johannesen, M. D., Hansen, H. H., Christiansen, S. H., Woldbye, D. P. D., Mikkelsen, J. D. & Lichota, J., 2012, In : Brain Research Bulletin. 88, 5, p. 507–513

Research output: Contribution to journalJournal articleResearchpeer-review

30 Citations (Scopus)

Impairment of interrelated iron- and copper homeostatic mechanisms in brain contributes to the pathogenesis of neurodegenerative disorders

Skjørringe, T., Møller, L. B. & Moos, T., 2012, In : Frontiers in Pharmacology. 3, p. Article No. 169 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

39 Citations (Scopus)

Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression

Henningsen, K., Johannesen, M. D., Bouzinova, E., Christiansen, S., Christensen, T., Andreasen, J. T., Palme, R., Lichota, J. & Wiborg, O., 2012, In : Behavioural Pharmacology. 23, 8, p. 735-743

Research output: Contribution to journalJournal articleResearchpeer-review

16 Citations (Scopus)
2011

Developmental iron uptake and axonal transport in the retina of the rat

Moos, T., Bernth, N., Courtois, Y. & Morgan, E. H., 2011, In : Molecular and Cellular Neuroscience. 46, 3, p. 607-613

Research output: Contribution to journalJournal articleResearchpeer-review

9 Citations (Scopus)

Gene delivery by pullulan derivatives in brain capillary endothelial cells for protein secretion

Thomsen, L. B., Lichota, J., Kim, K. S. & Moos, T., 2011, In : Journal of Controlled Release. 151, 1, p. 45-50

Research output: Contribution to journalJournal articleResearchpeer-review

42 Citations (Scopus)

Heterogenous distribution of ferroportin-containing neurons in mouse brain

Boserup, M. W., Lichota, J., Haile, D. & Moos, T., 2011, In : BioMetals. 24, 2, p. 357-375

Research output: Contribution to journalJournal articleResearchpeer-review

28 Citations (Scopus)
2010

Enabling drug delivery to cancer cells and tumor endothelium: the benefit of targeted therapy

Jeppesen, M. & Moos, T., 2010, In : Frontiers in Drug Design and Discovery. 5, p. 146-167

Research output: Contribution to journalJournal articleResearchpeer-review

Macromolecular drug transport into the brain using targeted therapy

Lichota, J., Skjørringe, T., Thomsen, L. B. & Moos, T., 2010, In : Journal of Neurochemistry. 113, 1, p. 1-13 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

51 Citations (Scopus)

Use of biomarkers in the discovery of novel anti-schizophrenia drugs

Mikkelsen, J. D., Thomsen, M. S., Hansen, H. & Lichota, J., 2010, In : Drug Discovery Today. 15, 3-4, p. 137-141 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

10 Citations (Scopus)
2009

Fulminant lymphocytic choriomeningitis virus-induced inflammation of the CNS involves a cytokine-chemokine-cytokine-chemokine cascade

Christensen, J. E., Simonsen, S., Fenger, C., Sorensen, M. R., Moos, T., Christensen, J. P., Finsen, B. & Thomsen, A. R., 2009, In : Journal of Immunology. 182, 2, p. 1079-1087

Research output: Contribution to journalJournal articleResearchpeer-review

34 Citations (Scopus)