Organization profile

Organisation profile

Our vision:

The research group Pain and Motor System Plasticity strives to gain a better understanding of the pain system and the involved neuroplasticity. We work with both healthy and patient populations with the aim of contributing to improve the quality of life for the people suffering from pain.

Our approach:

We do this by investigating fundamentals of the pain system, its neuroplasticity and interactions with the motor system through a multidisciplinary research approach, based on a translational strategy from basic experimental knowledge (provoking, probing, modulation, inhibition/facilitation), through clinical models (e.g. osteoarthritis, myofascial pain, work-related myalgia) to clinical screening (e.g. drug screening) and treatment.

We aim to:

  • Develop new technologies to measure and explore how we perceive, respond and recover from persistent pain and injury
  • Develop models reflecting mechanisms in persistent pain – provoking, probing and modulating pain neuroplasticity
  • Identify pain and/or inflammatory mechanisms which are associated to pain and to target these mechanisms
  • Identify pain-motor system interactions as well as motor-system behaviour preceding pain involvement 

Our core competences:

  • Technologies for pain and neuroplasticity induction (provocation) and modulation
  • Quantitative protocols and technologies for sensory assessment (probing)
  • Neurophysiological assessments (probing)
  • Computational modelling (e.g. tissue characteristics, biomechanics)

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    C19 Symptom Mapping

    Boudreau, S., Bøggild, H., Duroux, M. & Holden, S.

    26/03/2020 → …

    Project: Research

    Research Output

    Activation of the descending pain modulatory system using cuff pressure algometry: Back translation from man to rat

    Cummins, TM., Kucharczyk, M., Graven-Nielsen, T. & Bannister, K., 29 Apr 2020, In : European Journal of Pain.

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Activity Modification and Knee Strengthening for Osgood-Schlatter Disease: A Prospective Cohort Study

    Rathleff, M. S., Winiarski, L., Krommes, K., Graven-Nielsen, T., Hölmich, P., Olesen, J. L., Holden, S. & Thorborg, K., Apr 2020, In : Orthopaedic Journal of Sports Medicine. 8, 4, 2325967120911106.

    Research output: Contribution to journalJournal articleResearchpeer-review

    Open Access
  • 11 Downloads (Pure)

    Alterations in pro-nociceptive and anti-nociceptive mechanisms in patients with low back pain: a systematic review with meta-analysis

    McPhee, M. E., Vaegter, H. B. & Graven-Nielsen, T., Mar 2020, In : Pain. 161, 3, p. 464-475 12 p.

    Research output: Contribution to journalReview articleResearchpeer-review

  • Datasets

    C19 SymMaps survey data

    Boudreau, S. (Data Collector), VBN, 1 Apr 2020



    Best poster award

    Galve Villa, Maria (Recipient), 2019

    Prize: Conference prizes


    Itch from a neurophysiological and psychophysical perspective

    Hjalte Holm Andersen (Lecturer)

    16 Apr 2018

    Activity: Talks and presentationsGuest lecturers

    Scientific Reports (Journal)

    Hjalte Holm Andersen (Peer reviewer)

    2018 → …

    Activity: Editorial work and peer reviewPeer review of manuscriptsResearch

    Press / Media

    Ny tvivl om bækkenløsning

    Thorvaldur Palsson & Thomas Graven-Nielsen


    1 item of Media coverage

    Press/Media: Press / Media

    AAU-software skal kortlægge virussymptomer

    Shellie Boudreau


    1 item of Media coverage

    Press/Media: Press / Media