Projects per year
Organisation profile
Organisation profile
Head of research group: Lars Arendt-Nielsen
Co-chair: Kristian Kjær Petersen (Pain mechanisms by translational biomarker research)
Co-chair: Allan Stensballe (Inflammatory mechanisms and precision medicine by systems biology approaches)
Who we are?
An interdisciplinary and international research group with focus on translational human clinical research from wet laboratory to clinic. The aim is to understand disease pathophysiology and develop new biomarkers for profiling, screening and diagnostics. Our translational research team includes key competences within pain, omics, biosciences, bioengineering, medicine, neuroscience and neuropsychology. Our research takes a starting point in key global challenges linked to the WHO sustainable development goals.
Our research – what we do?
The Translational Biomarkers in Pain and Precision Medicine (TBPPM) Group investigates pathophysiology in key non-communicable diseases. Our translational research investigates the knowledge translation gap in major clinical challenges for patients and in particular those with pain and inflammatory conditions. One of our key competencies is pain profiling using sensory, inflammatory and imagining technologies for diagnosis and for identification of patients who are better suited for certain treatments. Similarly, we apply state-of-the-art post-genomic technologies to link disease pathology aspects through translational medicine research by biomarker-driven research to the patient in combination with the most inflammation profiling technologies. The goal is to generate knowledge, skills and competences for developing clinically applicable regimes for individualized personalized/precision medicine on pain and itch and to improve the treatment of chronic - in particular pain and inflammatory - diseases
How does our research contribute to societal health challenges?
The prevalence and incidence of non-communicable diseases has risen sharply in the last decades. These diseases are by far the leading cause of mortality and disability and they are responsible for up to 80% of health care costs. The global burdens of chronic pain and chronic itch are massive. The lack of adequate management of these disorders ranks high on the international research agenda. Mechanism-based biomarkers for screening, profiling and diagnostics will help developing personalized target management strategies. By combining psychophysics, questionnaires, genetics, proteomics, neuroimaging and electrophysiological disciplines, the group’s interdisciplinary composition is ideally staffed to gain novel disease insight and develop novel biomarkers.
Who are our key collaborators?
Aalborg University Hospital, Denmark; Aarhus University, Denmark; University of Southern Denmark; University of Copenhagen, Denmark, and related university hospitals; University of Washington, Seattle, USA; North Western University, Chicago; University of Calgary, Canada; Kochi Medical School, Kochi University; Meikai University, Japan; Örebro University Hospital, Sweden; Linköping University, Sweden; Rikshospitalet, Oslo University, Norway; University of Nottingham, UK; University of Rome “La Sapienza”, Italy; University of Parma, Italy; Universidad Rey Juan Carlos, Madrid, Spain; University of Sevilla, Spain; Ibselspital, University of Bern, Switzerland; Kiel University Hospital, Germany; Neomics Center (Shenzhen), China; The University of Queensland, Australia; and 10+ national and international companies.
Foto: Lars Horn
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Collaborations from the last five years
Profiles
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Giulia Erica Aliotta
- The Faculty of Medicine - Post.Doc.
- Department of Health Science and Technology - Post.Doc.
- Translational Biomarkers in Pain and Precision Medicine - Post.Doc.
- Center for Neuroplasticity and Pain
Person: VIP
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Jacob Skallerup Andersen
- The Faculty of Medicine - PhD Fellow, Research assistant
- Department of Health Science and Technology - PhD Fellow, Research assistant
- Translational Biomarkers in Pain and Precision Medicine
Person: VIP
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Danny Anthonimuthu
- The Faculty of Medicine - PhD Fellow
- Department of Health Science and Technology - PhD Fellow
- Translational Biomarkers in Pain and Precision Medicine - PhD Fellow
Person: VIP
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PLATO: National Platform for Proteomics and Biomedical Imaging
12/04/2024 → 01/04/2029
Project: Consultancy
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Novel biomarkers for improving outcomes for patients with chronic prosthetic joint infections
Stensballe, A. & Rasmussen, S.
01/01/2024 → 31/12/2027
Project: Research
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EUROSTARS Development of an innovative biosensor for continuous glucose monitoring with long operational life
Stensballe, A. & Rasmussen, S.
01/01/2024 → 31/12/2026
Project: Research
Research output
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A Digital Platform (Telepalliation) for Patients in Palliative Care and Their Relatives: Protocol for a Multi-method Randomized Controlled Trial
Sigaard, J. V. A., Henneberg, N. C., Schacksen, C. S., Kronborg, S. H., Petrini, L., Kidholm, K., Birgisdóttir, U. R., Spindler, H. & Dinesen, B., 2 Apr 2024, In: J M I R Research Protocols. 13, 1, 23 p., e49946.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Downloads (Pure) -
A potential link between inflammatory profiles, clinical pain, pain catastrophizing and long-term outcomes after total knee arthroplasty surgery
Giordano, R., Capriotti, C., Gerra, M. C., Kappel, A., Østgaard, S. E., Dallabona, C., Arendt-Nielsen, L. & Petersen, K. K-S., 26 Feb 2024, (E-pub ahead of print) In: European Journal of Pain.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access -
Bridging the translational gap: adenosine as a modulator of neuropathic pain in preclinical models and humans
Arendt-Nielsen, L., Klitgaard, H. & Hansen, S. N., Jan 2024, In: Scandinavian Journal of Pain. 24, 1, 20230048.Research output: Contribution to journal › Review article › peer-review
Open AccessFile7 Downloads (Pure)
Datasets
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Additional file 2 of Comparative proteomics analysis in different stages of urothelial bladder cancer for identification of potential biomarkers: highlighted role for antioxidant activity
Tabaei, S. (Creator), Haghshenas, M. R. (Creator), Ariafar, A. (Creator), Gilany, K. (Creator), Stensballe, A. (Creator), Farjadian, S. (Creator) & Ghaderi, A. (Creator), Figshare, 27 Jul 2023
DOI: 10.6084/m9.figshare.23797260.v1, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Comparative_proteomics_analysis_in_different_stages_of_urothelial_bladder_cancer_for_identification_of_potential_biomarkers_highlighted_role_for_antioxidant_activity/23797260/1 and one more link, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Comparative_proteomics_analysis_in_different_stages_of_urothelial_bladder_cancer_for_identification_of_potential_biomarkers_highlighted_role_for_antioxidant_activity/23797260 (show fewer)
Dataset: Supplementary material
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Additional file 3 of Comparative proteomics analysis in different stages of urothelial bladder cancer for identification of potential biomarkers: highlighted role for antioxidant activity
Tabaei, S. (Creator), Haghshenas, M. R. (Creator), Ariafar, A. (Creator), Gilany, K. (Creator), Stensballe, A. (Creator), Farjadian, S. (Creator) & Ghaderi, A. (Creator), Figshare, 27 Jul 2023
DOI: 10.6084/m9.figshare.23797263, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Comparative_proteomics_analysis_in_different_stages_of_urothelial_bladder_cancer_for_identification_of_potential_biomarkers_highlighted_role_for_antioxidant_activity/23797263
Dataset: Supplementary material
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Additional file 3 of Comparative proteomics analysis in different stages of urothelial bladder cancer for identification of potential biomarkers: highlighted role for antioxidant activity
Tabaei, S. (Creator), Haghshenas, M. R. (Creator), Ariafar, A. (Creator), Gilany, K. (Creator), Stensballe, A. (Creator), Farjadian, S. (Creator) & Ghaderi, A. (Creator), Figshare, 27 Jul 2023
DOI: 10.6084/m9.figshare.23797263.v1, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Comparative_proteomics_analysis_in_different_stages_of_urothelial_bladder_cancer_for_identification_of_potential_biomarkers_highlighted_role_for_antioxidant_activity/23797263/1
Dataset: Supplementary material
Prizes
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The Svend Andersen Talent Prize 2022
Petersen, Kristian Kjær-Staal (Recipient), 2022
Prize: Honorary prizes and appointments
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Best Abstract Prize
Petersen, Kristian Kjær-Staal (Recipient) & Larsen, Dennis Boye (Recipient), 7 Sept 2019
Prize: Conference prizes
Activities
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Second Ubuntu Proteomics Summer School
Allan Stensballe (Participant)
5 Feb 2024 → 9 Feb 2024Activity: Attending an event › Conference organisation or participation
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PhD opponent for Patryk Jerzy Drobinski
Allan Stensballe (Internal examiner)
22 Nov 2023Activity: Examination › External examination
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Next - Gen Immuno Oncology Conference - EU Edition
Allan Stensballe (Lecturer)
6 Oct 2023Activity: Talks and presentations › Conference presentations
Press/Media
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Populære opioid-piller er vanvittigt vanedannende og kan stoppe vejrtrækningen
29/02/2024
2 items of Media coverage
Press/Media: Press / Media
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Derfor er pepper x verdens stærkeste chili
14/02/2024 → 18/02/2024
11 items of Media coverage
Press/Media: Press / Media