• Fredrik Bajers Vej 3, B, 1-209

    9220 Aalborg Ø

    Denmark

20022019
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Research Output 2002 2019

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Journal article
2019

Fabrication and characterization of extracellular matrix scaffolds obtained from adipose-derived stem cells

Riis, S., Hansen, A. C., Johansen, L., Lund, K., Pedersen, C., Pitsa, A., Hyldig, K., Zachar, V., Fink, T. & Pennisi, C. P., 9 Jul 2019, In : Methods.

Research output: Contribution to journalJournal articleResearchpeer-review

Stem cells
Scaffolds
Extracellular Matrix
Stem Cells
Wound Healing
2018
2 Citations (Scopus)

Focal adhesion kinase activation is necessary for stretch-induced alignment and enhanced differentiation of myogenic precursor cells

Andersen, J. I., Pennisi, C. P., Fink, T. & Zachar, V., 1 Apr 2018, In : Tissue Engineering. Part A. 24, 7-8, p. 631-640 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Focal Adhesion Protein-Tyrosine Kinases
Adhesion
Chemical activation
Tensile strain
Myoblasts
3 Citations (Scopus)
115 Downloads (Pure)

Hypoxia enhances differentiation of adipose tissue-derived stem cells toward the smooth muscle phenotype

Wang, F., Zachar, V., Pennisi, C. P., Fink, T., Maeda, Y. & Emmersen, J., 2018, In : International Journal of Molecular Sciences . 19, 2, 12 p., 517.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
adipose tissues
smooth muscle
phenotype
stem cells
hypoxia
3 Citations (Scopus)
76 Downloads (Pure)

Pigmentation is associated with stemness hierarchy of progenitor cells within cultured limbal epithelial cells

Liu, L., Nielsen, F. M., Emmersen, J., Bath, C., Hjortdal, J. Ø., Riis, S., Fink, T., Pennisi, C. P. & Zachar, V., Sep 2018, In : Stem Cells. 36, 9, p. 1411-1420 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Pigmentation
Stem Cells
Epithelial Cells
Adenosine Triphosphate
Keratin-3

Regeneration of the oesophageal muscle layer from oesophagus acellular matrix scaffold using adipose-derived stem cells

Wang, F., Maeda, Y., Zachar, V., Ansari, T. & Emmersen, J., 3 Sep 2018, In : Biochemical and Biophysical Research Communications. 503, 1, p. 271-277 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Stem cells
Scaffolds
Esophagus
Muscle
Regeneration
2017
6 Citations (Scopus)
173 Downloads (Pure)

Hypoxia enhances the wound-healing potential of adipose-derived stem cells in a novel human primary keratinocyte-based scratch assay

Riis, S., Newman, R., Ipek, H., Andersen, J. I., Kuninger, D., Boucher, S., Vemuri, M. C., Pennisi, C. P., Zachar, V. & Fink, T., 2017, In : International Journal of Molecular Medicine. 39, 3, p. 587-594

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Keratinocytes
Wound Healing
Stem Cells
Calcium
Conditioned Culture Medium
2 Citations (Scopus)
224 Downloads (Pure)

Maintaining RNA integrity for transcriptomic profiling of ex vivo cultured limbal epithelial stem cells after fluorescence-activated cell sorting (FACS)

Liu, L., Nielsen, F. M., Riis, S. E., Emmersen, J., Fink, T., Hjortdal, J. Ø., Bath, C. & Zachar, V., 12 Dec 2017, In : Biological Procedures Online. 19, 7 p., 15.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Stem cells
Sorting
Flow Cytometry
Stem Cells
Epithelial Cells
2016
18 Citations (Scopus)
190 Downloads (Pure)

Boron-doped nanocrystalline diamond electrodes for neural interfaces: in vivo biocompatibility evaluation

Alcaide, M., Taylor, A., Fjorback, M., Zachar, V. & Pennisi, C. P., 2016, In : Frontiers in Neuroscience. 10, 9 p., 87.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Diamond
Boron
Electrodes
Implanted Electrodes
Capsules
18 Citations (Scopus)

Comparative analysis of media and supplements on initiation and expansion of adipose-derived stem cells

Riis, S., Nielsen, F. M., Pennisi, C. P., Zachar, V. & Fink, T., 2016, In : Stem Cells Translational Medicine. 5, 3, p. 314-324

Research output: Contribution to journalJournal articleResearchpeer-review

Stem Cells
Blood Platelets
Serum
Eagles
Serum-Free Culture Media
4 Citations (Scopus)
183 Downloads (Pure)

Discrete adipose-derived stem cell subpopulations may display differential functionality after in vitro expansion despite convergence to a common phenotype distribution

Nielsen, F. M., Riis, S. E., Andersen, J. I., Lesage, R., Fink, T., Pennisi, C. P. & Zachar, V., 2016, In : Stem Cell Research & Therapy. 7, 13 p., 177.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Stem cells
Stem Cells
Phenotype
Flow cytometry
Wound Healing
18 Citations (Scopus)
291 Downloads (Pure)
Open Access
File
7 Citations (Scopus)

Resistance to protein adsorption and adhesion of fibroblasts on nanocrystalline diamond films: the role of topography and boron doping

Alcaide, M., Papaioannou, S., Taylor, A., Fekete, L., Gurevich, L., Zachar, V. & Pennisi, C. P., 2016, In : Journal of Materials Science: Materials in Medicine. 27, 5, 12 p., 90.

Research output: Contribution to journalJournal articleResearchpeer-review

Diamond
Boron
Diamond films
Fibroblasts
Topography
2015
4 Citations (Scopus)
254 Downloads (Pure)

Synthesis of nano- and micro-scale topographies by combining colloidal lithography and glancing angle deposition (GLAD)

Dolatshahi-Pirouz, A., Kolind, K., Pennisi, C. P., Duroux, M., Zachar, V., Foss, M. & Besenbacher, F., 2015, In : Advanced Engineering Materials. 17, 1, p. 8-13

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
2014
39 Citations (Scopus)

Comparison of human adipose-derived stem cells and bone marrow-derived stem cells in a myocardial infarction model

Rasmussen, J., Frøbert, O., Holst-Hansen, C., Kastrup, J., Baandrup, U., Zachar, V., Fink, T. & Simonsen, U., 2014, In : Cell Transplantation. 23, 2, p. 195-206

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
15 Citations (Scopus)

Cripto-1 expression in glioblastoma multiforme

Pilgaard, L., Mortensen, J. H., Henriksen, M., Olesen, P., Sørensen, P., Laursen, R. J., Vyberg, M., Agger, R., Zachar, V., Moos, T. & Duroux, M., 2014, In : Brain Pathology. 24, 4, p. 360–370

Research output: Contribution to journalJournal articleResearchpeer-review

13 Citations (Scopus)

Hypoxia enhances chondrogenic differentiation of human adipose tissue-derived stromal cells in scaffold-free and scaffold systems

Munir, S., Foldager, C. B., Lind, M., Zachar, V., Søballe, K. & Koch, T. G., 2014, In : Cell and Tissue Research. 355, 1, p. 89-102

Research output: Contribution to journalJournal articleResearchpeer-review

6 Citations (Scopus)

Moderate hypoxia influences potassium outward currents in adipose-derived stem cells

Prasad, M. S., Zachar, V., Fink, T. & Pennisi, C. P., 2014, In : P L o S One. 9, 8, 10 p., e104912.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
2 Citations (Scopus)

Technical brief: Optimized pipeline for isolation of high-quality RNA from corneal cell subpopulations

Søndergaard, C. B., Fink, T., Vorum, H., Hjortdal, J. & Zachar, V., 2014, In : Molecular Vision. 20, p. 797-803

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
11 Citations (Scopus)

Uniaxial cyclic strain enhances adipose-derived stem cell fusion with skeletal myocytes

Andersen, J. I., Juhl, M., Nielsen, T., Emmersen, J., Fink, T., Zachar, V. & Pennisi, C. P., 2014, In : Biochemical and Biophysical Research Communications. 450, 2, p. 1083-1088

Research output: Contribution to journalJournal articleResearchpeer-review

2013
28 Citations (Scopus)

Development of cardiac support bioprostheses for ventricular restoration and myocardial regeneration

Shafy, A., Fink, T., Zachar, V., Lila, N., Carpentier, A. & Chachques, J. C., 2013, In : European Journal of Cardio-Thoracic Surgery. 43, 6, p. 1211-1219

Research output: Contribution to journalJournal articleResearchpeer-review

2 Citations (Scopus)

Elliptical posts allow for detailed control of non-equibiaxial straining of cell cultures

Olesen, C. G., Pennisi, C. P., de Zee, M., Zachar, V. & Rasmussen, J., May 2013, In : Journal of Tissue Viability. 22, 2, p. 52-56 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

15 Citations (Scopus)

Hypoxia is a key regulator of limbal epithelial stem cell growth and differentiation

Søndergaard, C. B., Yang, S., Muttuvelu, D. V., Fink, T., Emmersen, J., Vorum, H., Hjortdal, J. Ø. & Zachar, V., May 2013, In : Stem Cell Research. 10, 3, p. 349–360 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cell Differentiation
Stem Cells
Epithelial Cells
Oxygen
Growth

Targeted antiepidermal growth factor receptor (Cetuximab) immunoliposomes enhance cellular uptake in vitro and exhibit increased accumulation in an intracranial model of glioblastoma multiforme

Mortensen, J. H., Jeppesen, M., Pilgaard, L., Agger, R., Duroux, M., Zachar, V. & Moos, T., 2013, In : Journal of Drug Delivery. 2013, p. Article No. 209205 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

16 Citations (Scopus)

Transcriptional dissection of human limbal niche compartments by massive parallel sequencing

Søndergaard, C. B., Muttuvelu, D., Emmersen, J., Vorum, H., Hjortdal, J. Ø. & Zachar, V., 2013, In : P L o S One. 8, 5, e64244.

Research output: Contribution to journalJournal articleResearchpeer-review

Dissection
Stem cells
niches
Genes
stem cells
2012
20 Citations (Scopus)

Activation of protease-activated receptor 2 induces VEGF independently of HIF-1

Rasmussen, J., Riis, S. E., Frøbert, O., Yang, S., Kastrup, J., Zachar, V., Simonsen, U. & Fink, T., 25 Sep 2012, In : P L o S One. 7, 9, p. Article No. e46087

Research output: Contribution to journalJournal articleResearchpeer-review

29 Citations (Scopus)

Defined xenogeneic-free and hypoxic environment provides superior conditions for long-term expansion of human adipose-derived stem cells

Yang, S., Pilgaard, L., Chase, L. G., Boucher, S., Vemuri, M. C., Fink, T. & Zachar, V., 2012, In : Tissue Engineering. Part C. Methods. 18, 8, p. 593-602

Research output: Contribution to journalJournal articleResearchpeer-review

63 Citations (Scopus)

Development and characterization of a clinically compliant xeno-free culture medium in good manufacturing practice for human multipotent mesenchymal stem cells

Chase, L. G., Yang, S., Zachar, V., Yang, Z., Lakshmipathy, U., Bradford, J., Boucher, S. E. & Vemuri, M. C., 2012, In : Stem Cells Translational Medicine. 1, 10, p. 750-758

Research output: Contribution to journalJournal articleResearchpeer-review

13 Citations (Scopus)

Increased connective tissue attachment to silicone implants by a water vapor plasma treatment

Jensen, C., Gurevich, L., Patriciu, A., Struijk, J., Zachar, V. & Pennisi, C. P., 2012, In : Journal of Biomedical Materials Research. Part A. 100A, 12, p. 3400-3407

Research output: Contribution to journalJournal articleResearchpeer-review

23 Citations (Scopus)

Patterned poly(lactic acid) films support growth and spontaneous multilineage gene expression of adipose-derived stem cells

Nielsen, S. F., Petersen, M., Fojan, P., Gurevich, L., Fink, T., Pennisi, C. P. & Zachar, V., 2012, In : Colloids and Surfaces B: Biointerfaces. 93, p. 92-99

Research output: Contribution to journalJournal articleResearchpeer-review

2011
40 Citations (Scopus)

Adipogenic differentiation of human mesenchymal stem cells

Fink, T. & Zachar, V., 2011, In : Methods in Molecular Biology. 698, p. 243-251, kap. 19

Research output: Contribution to journalJournal articleResearchpeer-review

28 Citations (Scopus)

Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation in vitro

Fink, T., Rasmussen, J., Emmersen, J., Pilgaard, L., Fahlman, Å., Brunberg, S., Josefsson, J., Arnemo, J. M., Zachar, V., Swenson, J. E. & Fröbert, O., 2011, In : Stem Cell Research. 7, 1, p. 89-95

Research output: Contribution to journalJournal articleResearchpeer-review

34 Citations (Scopus)

Hypoxia and adipose-derived stem cell-based tissue regeneration and engineering

Zachar, V., Duroux, M., Emmersen, J., Rasmussen, J. G., Pennisi, C. P., Yang, S. & Fink, T., 2011, In : Expert Opinion on Biological Therapy. 11, 6, p. 775-786

Research output: Contribution to journalJournal articleResearchpeer-review

26 Citations (Scopus)

Isolation and expansion of adipose-derived stem cells for tissue engineering

Fink, T., Rasmussen, J. G., Lund, P., Pilgaard, L., Søballe, K. & Zachar, V., 2011, In : Frontiers in Bioscience. E3, 1, p. 256-263 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cell Engineering
Tissue Engineering
Stem cells
Tissue engineering
Stem Cells
30 Citations (Scopus)

Isolation and growth of adipose tissue-derived stem cells

Zachar, V., Rasmussen, J. & Fink, T., 2011, In : Methods in Molecular Biology. 698, p. 37-49, kap. 4

Research output: Contribution to journalJournal articleResearchpeer-review

52 Citations (Scopus)

Nanoscale topography reduces fibroblast growth, focal adhesion size and migration-related gene expression on platinum surfaces

Pennisi, C. P., Dolatshahi-Pirouz, A., Foss, M., Chevallier, J., Fink, T., Zachar, V., Besenbacher, F. & Yoshida, K., 2011, In : Colloids and Surfaces B: Biointerfaces. 85, 2, p. 189-197

Research output: Contribution to journalJournal articleResearchpeer-review

68 Citations (Scopus)

Prolonged hypoxic culture and trypsinization increase the pro-angiogenic potential of human adipose tissue-derived stem cells

Rasmussen, J. G., Frøbert, O., Pilgaard, L., Kastrup, J., Simonsen, U., Zachar, V. & Fink, T., 2011, In : Cytotherapy. 13, 3, p. 318-328 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

31 Citations (Scopus)

Uniaxial cyclic strain drives assembly and differentiation of skeletal myocytes

Pennisi, C. P., Olesen, C. G., de Zee, M., Rasmussen, J. & Zachar, V., 2011, In : Tissue Engineering. Part A. Tissue Engineering. 17, 19-20, p. 2543-2550

Research output: Contribution to journalJournal articleResearchpeer-review

2010
3 Citations (Scopus)

Notch and Hedgehog signaling cooperate to maintain self-renewal of human embryonic stem cells exposed to low oxygen concentration

Weli, S. C., Fink, T., Cetinkaya, C., Prasad, M. S., Pennisi, C. P. & Zachar, V., 2010, In : International Journal of Stem Cells. 3, 2, p. 129-137 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

25 Citations (Scopus)

The effect of human embryonic stem cells (hESCs) long-term normoxic and hypoxic cultures on the maintenance of pluripotency

Zachar, V., Prasad, M. S., Weli, S. C., Gabrielsen, A., Petersen, K., Petersen, M. B. & Fink, T., 2010, In : In Vitro Cellular & Developmental Biology - Animal. 46, 3-4, p. 276-283 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2009
72 Citations (Scopus)

Continuous hypoxic culturing maintains activation of Notch and allows long-term propagation of human embryonic stem cells without spontaneous differentiation

Prasad, M. S., Czepiel, M., Cetinkaya, C., Smigielska, K., Weli, S. C., Lysdahl, H., Gabrielsen, A., Petersen, K., Ehlers, N., Fink, T., Minger, S. L. & Zachar, V., 2009, In : Cell Proliferation. 42, 1, p. 63-74

Research output: Contribution to journalJournal articleResearchpeer-review

62 Citations (Scopus)

Effect of growth media and serum replacements on the proliferation and differentiation of adipose-derived stem cells

Lund, P., Pilgaard, L., Crookshanks, M., Fink, T. & Zachar, V., 2009, In : Cytotherapy. 11, 2, p. 189-197

Research output: Contribution to journalJournal articleResearchpeer-review

33 Citations (Scopus)

Effect of oxygen concentration, culture format and donor variability on in vitro chondrogenesis of human adipose tissue-derived stem cells

Pilgaard, L., Lund, P., Duroux, M., Fink, T., Ulrich-Vinter, M., Søballe, K. & Zachar, V., 2009, In : Regenerative Medicine. 4, 4, p. 539-548

Research output: Contribution to journalJournal articleResearchpeer-review

6 Citations (Scopus)

Incorporation of photosynthetic reaction centers in the membrane of human cells: toward a new tool for optical control of cell activity

Pennisi, C. P., Jensen, P. E., Zachar, V., Greenbaum, E. & Yoshida, K., 2009, In : Cellular and Molecular Bioengeneering. 2, 1, p. 156-165

Research output: Contribution to journalJournal articleResearchpeer-review

8 Citations (Scopus)

Minimal engraftment of human CD34+ cells mobilized from healthy donors in the infarcted heart of athymic nude rats

Sondergaard, C. S., Bonde, J., Dagnæs-Hansen, F., Nielsen, J. M., Zachar, V., Holm, M., Hokland, P. & Pedersen, L., 2009, In : Stem Cells and Development. 18, 6, p. 845-855

Research output: Contribution to journalJournal articleResearchpeer-review

29 Citations (Scopus)

Responses of fibroblasts and glial cells to nanostructured platinum surfaces

Pennisi, C. P., Sevcencu, C., Dolatshahi-Pirouz, A., Foss, M., Hansen, J. L., Larsen, A. N., Zachar, V., Besenbacher, F. & Yoshida, K., 2009, In : Nanotechnology. 20, 38, p. Article ID 385103 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

42 Citations (Scopus)

The influence of glancing angle deposited nano-rough platinum surfaces on the adsorption of fibrinogen and the proliferation of primary human fibroblasts

Dolatshahi-Pirouz, A., Pennisi, C. P., Skeldal, S., Foss, M., Chevallier, J., Zachar, V., Andreasen, P., Yoshida, K. & Besenbacher, F., 2009, In : Nanotechnology. 20, 9, 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

37 Citations (Scopus)

Transcriptional signature of human adipose tissue-derived stem cells (hASCs) preconditioned for chondrogenesis in hypoxic conditions

Pilgaard, L., Lund, P., Duroux, M., Lockstone, H., Taylor, J., Emmersen, J., Fink, T., Ragoussis, J. & Zachar, V., 2009, In : Experimental Cell Research. 315, 11, p. 1937-1952

Research output: Contribution to journalJournal articleResearchpeer-review

2008
30 Citations (Scopus)

Comparative analysis of highly defined proteases for the isolation of adipose tissue-derived stem cells

Pilgaard, L., Lund, P., Rasmussen, J. G., Fink, T. & Zachar, V., 2008, In : Regenerative Medicine. 3, 5, p. 705-715

Research output: Contribution to journalJournal articleResearchpeer-review

72 Citations (Scopus)

Improved cellular activity of antisense peptide nucleic acids by conjugation to a cationic peptide-lipid (CatLip) domain

Koppelhus, U., Shiraishi, T., Zachar, V., Pankratova, S. & Nielsen, P. E., 2008, In : Bioconjugate Chemistry. 19, 8, p. 1526-1534

Research output: Contribution to journalJournal articleResearchpeer-review

96 Citations (Scopus)

Instability of standard PCR reference genes in adipose-derived stem cells during propagation, differentiation and hypoxic exposure

Fink, T., Lund, P., Pilgaard, L., Rasmussen, J. G., Duroux, M. & Zachar, V., 2008, In : BMC Molecular Biology. 9, 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review