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Research Output 2002 2019

2019

Fabrication and characterization of extracellular matrix scaffolds obtained from adipose-derived stem cells

Riis, S., Hansen, A. C., Johansen, L., Lund, K., Pedersen, C., Pitsa, A., Hyldig, K., Zachar, V., Fink, T. & Pennisi, C. P., 9 Jul 2019, In : Methods.

Research output: Contribution to journalJournal articleResearchpeer-review

Stem cells
Scaffolds
Extracellular Matrix
Stem Cells
Wound Healing
2018
2 Citations (Scopus)

Focal adhesion kinase activation is necessary for stretch-induced alignment and enhanced differentiation of myogenic precursor cells

Andersen, J. I., Pennisi, C. P., Fink, T. & Zachar, V., 1 Apr 2018, In : Tissue Engineering. Part A. 24, 7-8, p. 631-640 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Focal Adhesion Protein-Tyrosine Kinases
Adhesion
Chemical activation
Tensile strain
Myoblasts
3 Citations (Scopus)
118 Downloads (Pure)

Hypoxia enhances differentiation of adipose tissue-derived stem cells toward the smooth muscle phenotype

Wang, F., Zachar, V., Pennisi, C. P., Fink, T., Maeda, Y. & Emmersen, J., 2018, In : International Journal of Molecular Sciences . 19, 2, 12 p., 517.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
adipose tissues
smooth muscle
phenotype
stem cells
hypoxia
3 Citations (Scopus)
80 Downloads (Pure)

Pigmentation is associated with stemness hierarchy of progenitor cells within cultured limbal epithelial cells

Liu, L., Nielsen, F. M., Emmersen, J., Bath, C., Hjortdal, J. Ø., Riis, S., Fink, T., Pennisi, C. P. & Zachar, V., Sep 2018, In : Stem Cells. 36, 9, p. 1411-1420 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Pigmentation
Stem Cells
Epithelial Cells
Adenosine Triphosphate
Keratin-3
2017
7 Citations (Scopus)
176 Downloads (Pure)

Hypoxia enhances the wound-healing potential of adipose-derived stem cells in a novel human primary keratinocyte-based scratch assay

Riis, S., Newman, R., Ipek, H., Andersen, J. I., Kuninger, D., Boucher, S., Vemuri, M. C., Pennisi, C. P., Zachar, V. & Fink, T., 2017, In : International Journal of Molecular Medicine. 39, 3, p. 587-594

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Keratinocytes
Wound Healing
Stem Cells
Calcium
Conditioned Culture Medium
15 Citations (Scopus)
158 Downloads (Pure)

Implications of extracellular matrix production by adipose tissue-derived stem cells for development of wound healing therapies

Hyldig, K., Riis, S., Pennisi, C. P., Zachar, V. & Fink, T., 31 May 2017, In : International Journal of Molecular Sciences . 18, 6, 11 p., 1167.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
File
adipose tissues
wound healing
stem cells
Stem cells
Wound Healing
2 Citations (Scopus)
235 Downloads (Pure)

Maintaining RNA integrity for transcriptomic profiling of ex vivo cultured limbal epithelial stem cells after fluorescence-activated cell sorting (FACS)

Liu, L., Nielsen, F. M., Riis, S. E., Emmersen, J., Fink, T., Hjortdal, J. Ø., Bath, C. & Zachar, V., 12 Dec 2017, In : Biological Procedures Online. 19, 7 p., 15.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Stem cells
Sorting
Flow Cytometry
Stem Cells
Epithelial Cells

Selective expansion of limbal epithelial stem cells in culture using hypoxia

Bath, C., Yang, S., Muttuvelu, D., Fink, T., Emmersen, J., Vorum, H., Hjortdal, J. & Zachar, V., 2017, The Stem Cell Microenvironment and its Role in Regenerative Medicine and Cancer Pathogenesis. Pennisi, C. P., Prasad, M. S. & Rameshwar, P. (eds.). River Publishers, p. 1-11 (River Publishers Series in Research and Business Chronicles: Biotechnology and Medicine; No. 7).

Research output: Contribution to book/anthology/report/conference proceedingBook chapterResearchpeer-review

2016
19 Citations (Scopus)

Comparative analysis of media and supplements on initiation and expansion of adipose-derived stem cells

Riis, S., Nielsen, F. M., Pennisi, C. P., Zachar, V. & Fink, T., 2016, In : Stem Cells Translational Medicine. 5, 3, p. 314-324

Research output: Contribution to journalJournal articleResearchpeer-review

Stem Cells
Blood Platelets
Serum
Eagles
Serum-Free Culture Media
4 Citations (Scopus)
187 Downloads (Pure)

Discrete adipose-derived stem cell subpopulations may display differential functionality after in vitro expansion despite convergence to a common phenotype distribution

Nielsen, F. M., Riis, S. E., Andersen, J. I., Lesage, R., Fink, T., Pennisi, C. P. & Zachar, V., 2016, In : Stem Cell Research & Therapy. 7, 13 p., 177.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Stem cells
Stem Cells
Phenotype
Flow cytometry
Wound Healing
15 Citations (Scopus)

Environmental chemicals modulate polar bear (Ursus maritimus) peroxisome proliferator-activated receptor gamma (PPARG) and adipogenesis in vitro

Routti, H., Lille-Langøy, R., Berg, M. K., Fink, T., Harju, M., Kristiansen, K., Rostkowski, P., Rusten, M., Sylte, I., Øygarden, L. & Goksøyr, A., 2016, In : Environmental Science & Technology. 50, 19, p. 10708-10720

Research output: Contribution to journalJournal articleResearchpeer-review

PPAR gamma
bear
Tissue
Stem cells
Impurities
6 Citations (Scopus)

Hypoxia enhances differentiation of adipose-derived stem cells to smooth muscle cells

Wang, F., Zachar, V., Pennisi, C. P., Fink, T., Maeda, Y. & Emmersen, J., 2016, Abstracts, The American Society of Colon and Rectal Surgeons Annual Scientific Meeting, ASCRS, 30 April-4 May 2016, Los Angeles, CA, USA. American Society of Colon and Rectal Surgeons, p. 50-51 P1

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

Open Access

Hypoxia enhances differentiation of adipose-derived stem cells to smooth muscle cells

Wang, F., Zachar, V., Pennisi, C. P., Fink, T., Maeda, Y. & Emmersen, J., 2016, In : Diseases of the Colon and Rectum. 59, 5, p. E123 P1.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

19 Citations (Scopus)
294 Downloads (Pure)
Open Access
File

Pooled human platelet lysate supports the isolation and efficient expansion of skeletal muscle myoblasts

Pennisi, C. P., Riis, S. E., Boyer, A., Fink, T. & Zachar, V., 2016, Abstracts, DASCS Stem Cell Conference 2016, 10-11 November 2016, Copenhagen, Denmark. Danish Stem Cell Society, p. 23 P10

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

2015
24 Citations (Scopus)

Critical steps in the isolation and expansion of adipose-derived stem cells for translational therapy

Riis, S. E., Zachar, V., Boucher, S., Vemuri, M. C., Pennisi, C. P. A. & Fink, T., 2015, In : Expert Reviews in Molecular Medicine. 17, 11 p., e11.

Research output: Contribution to journalReview articleResearchpeer-review

2014
39 Citations (Scopus)

Comparison of human adipose-derived stem cells and bone marrow-derived stem cells in a myocardial infarction model

Rasmussen, J., Frøbert, O., Holst-Hansen, C., Kastrup, J., Baandrup, U., Zachar, V., Fink, T. & Simonsen, U., 2014, In : Cell Transplantation. 23, 2, p. 195-206

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

From cases to projects in problem-based medical education

Stentoft, D., Duroux, M., Fink, T. & Emmersen, J., 2014, In : Journal of Problem Based Learning in Higher Education. 2, 1, p. 45-62

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Investigation of ASC-mediated wound healing in in vitro skin injury models

Riis, S. E., Newman, R., Kuninger, D., Boucher, S., Vermuri, M., Zachar, V. & Fink, T., 2014, In : Cytotherapy. 16, 4, Suppl., p. S93 Abstract No. 326.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

6 Citations (Scopus)

Moderate hypoxia influences potassium outward currents in adipose-derived stem cells

Prasad, M. S., Zachar, V., Fink, T. & Pennisi, C. P., 2014, In : P L o S One. 9, 8, 10 p., e104912.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
2 Citations (Scopus)

Technical brief: Optimized pipeline for isolation of high-quality RNA from corneal cell subpopulations

Søndergaard, C. B., Fink, T., Vorum, H., Hjortdal, J. & Zachar, V., 2014, In : Molecular Vision. 20, p. 797-803

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
11 Citations (Scopus)

Uniaxial cyclic strain enhances adipose-derived stem cell fusion with skeletal myocytes

Andersen, J. I., Juhl, M., Nielsen, T., Emmersen, J., Fink, T., Zachar, V. & Pennisi, C. P., 2014, In : Biochemical and Biophysical Research Communications. 450, 2, p. 1083-1088

Research output: Contribution to journalJournal articleResearchpeer-review

Using adipose stem cells for wound healing

Fink, T., 2014, Proceedings of the 5th Disputationes : Addressing Organ Regeneration and Tissue Repair by Artificial Supports, 12-13 May 2014, Aalborg, Denmark.

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearch

2013
28 Citations (Scopus)

Development of cardiac support bioprostheses for ventricular restoration and myocardial regeneration

Shafy, A., Fink, T., Zachar, V., Lila, N., Carpentier, A. & Chachques, J. C., 2013, In : European Journal of Cardio-Thoracic Surgery. 43, 6, p. 1211-1219

Research output: Contribution to journalJournal articleResearchpeer-review

15 Citations (Scopus)

Hypoxia is a key regulator of limbal epithelial stem cell growth and differentiation

Søndergaard, C. B., Yang, S., Muttuvelu, D. V., Fink, T., Emmersen, J., Vorum, H., Hjortdal, J. Ø. & Zachar, V., May 2013, In : Stem Cell Research. 10, 3, p. 349–360 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cell Differentiation
Stem Cells
Epithelial Cells
Oxygen
Growth
5 Citations (Scopus)

Patterned polymeric surfaces to study the influence of nanotopography on the growth and differentiation of mesenchymal stem cells

Pennisi, C. P., Zachar, V., Fink, T., Gurevich, L. & Fojan, P., 2013, Stem Cell Nanotechnology: Methods and Protocols. Turksen, K. (ed.). Humana Press, Vol. 1058. p. 77-88 (Methods in Molecular Biology).

Research output: Contribution to book/anthology/report/conference proceedingBook chapterResearchpeer-review

Reflection on the Diversity and Change of PBL From a Comparison of Three PBL Models in Medical Education

Du, X., Emmersen, J., Fink, T., Toft, E. & Sun, B., 30 Sep 2013, Visions, Challenges, and Strategies: PBL Principles and Methodologies in a Danish and Global Perspective. Krogh, L. & Jensen, A. A. (eds.). 1 ed. Aalborg Universitet: Aalborg Universitetsforlag, p. 221-241 21 p.

Research output: Contribution to book/anthology/report/conference proceedingBook chapterResearchpeer-review

2012
20 Citations (Scopus)

Activation of protease-activated receptor 2 induces VEGF independently of HIF-1

Rasmussen, J., Riis, S. E., Frøbert, O., Yang, S., Kastrup, J., Zachar, V., Simonsen, U. & Fink, T., 25 Sep 2012, In : P L o S One. 7, 9, p. Article No. e46087

Research output: Contribution to journalJournal articleResearchpeer-review

29 Citations (Scopus)

Defined xenogeneic-free and hypoxic environment provides superior conditions for long-term expansion of human adipose-derived stem cells

Yang, S., Pilgaard, L., Chase, L. G., Boucher, S., Vemuri, M. C., Fink, T. & Zachar, V., 2012, In : Tissue Engineering. Part C. Methods. 18, 8, p. 593-602

Research output: Contribution to journalJournal articleResearchpeer-review

24 Citations (Scopus)

Patterned poly(lactic acid) films support growth and spontaneous multilineage gene expression of adipose-derived stem cells

Nielsen, S. F., Petersen, M., Fojan, P., Gurevich, L., Fink, T., Pennisi, C. P. & Zachar, V., 2012, In : Colloids and Surfaces B: Biointerfaces. 93, p. 92-99

Research output: Contribution to journalJournal articleResearchpeer-review

2011
40 Citations (Scopus)

Adipogenic differentiation of human mesenchymal stem cells

Fink, T. & Zachar, V., 2011, In : Methods in Molecular Biology. 698, p. 243-251, kap. 19

Research output: Contribution to journalJournal articleResearchpeer-review

28 Citations (Scopus)

Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation in vitro

Fink, T., Rasmussen, J., Emmersen, J., Pilgaard, L., Fahlman, Å., Brunberg, S., Josefsson, J., Arnemo, J. M., Zachar, V., Swenson, J. E. & Fröbert, O., 2011, In : Stem Cell Research. 7, 1, p. 89-95

Research output: Contribution to journalJournal articleResearchpeer-review

Growth of human embryonic stem cells in long-term hypoxia

Zachar, V., Weli, S. C., Prasad, M. S. & Fink, T., 2011, Human embryonic and induced pluripotent stem cells: lineage-specific differentiation protocols. Ye, K. & Jin, S. (eds.). Humana Press, p. 13-24 (Springer Protocols Handbooks).

Research output: Contribution to book/anthology/report/conference proceedingBook chapterResearchpeer-review

34 Citations (Scopus)

Hypoxia and adipose-derived stem cell-based tissue regeneration and engineering

Zachar, V., Duroux, M., Emmersen, J., Rasmussen, J. G., Pennisi, C. P., Yang, S. & Fink, T., 2011, In : Expert Opinion on Biological Therapy. 11, 6, p. 775-786

Research output: Contribution to journalJournal articleResearchpeer-review

In human adipose stem cells trypsin treatment upregulates expression and secretion of VEGF in a manner independent of hypoxia inducible factor 1

Fink, T., Rasmussen, J., Riis, S. E., Lundsted, D. H., Larsen, B. F., Frobert, O., Kastrup, J., Simonsen, U. & Zachar, V., 2011, Miami IFATS 2011 Conference: [The 9th Annual Symposium on Adipose Stem Cells and Clinical Applications of Adipose Tissue], 4-6 November 2011, Miami, FL, USA. International Federation for Adipose Therapeutics and Science, IFATS, p. 84, No. 109

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

26 Citations (Scopus)

Isolation and expansion of adipose-derived stem cells for tissue engineering

Fink, T., Rasmussen, J. G., Lund, P., Pilgaard, L., Søballe, K. & Zachar, V., 2011, In : Frontiers in Bioscience. E3, 1, p. 256-263 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cell Engineering
Tissue Engineering
Stem cells
Tissue engineering
Stem Cells
30 Citations (Scopus)

Isolation and growth of adipose tissue-derived stem cells

Zachar, V., Rasmussen, J. & Fink, T., 2011, In : Methods in Molecular Biology. 698, p. 37-49, kap. 4

Research output: Contribution to journalJournal articleResearchpeer-review

52 Citations (Scopus)

Nanoscale topography reduces fibroblast growth, focal adhesion size and migration-related gene expression on platinum surfaces

Pennisi, C. P., Dolatshahi-Pirouz, A., Foss, M., Chevallier, J., Fink, T., Zachar, V., Besenbacher, F. & Yoshida, K., 2011, In : Colloids and Surfaces B: Biointerfaces. 85, 2, p. 189-197

Research output: Contribution to journalJournal articleResearchpeer-review

69 Citations (Scopus)

Prolonged hypoxic culture and trypsinization increase the pro-angiogenic potential of human adipose tissue-derived stem cells

Rasmussen, J. G., Frøbert, O., Pilgaard, L., Kastrup, J., Simonsen, U., Zachar, V. & Fink, T., 2011, In : Cytotherapy. 13, 3, p. 318-328 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2010

Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation

Fink, T. & Zachar, V., 2010, In : Differentiation. 80, Suppl. 1, p. S37, No. P61

Research output: Contribution to journalConference abstract in journalResearch

3 Citations (Scopus)

Notch and Hedgehog signaling cooperate to maintain self-renewal of human embryonic stem cells exposed to low oxygen concentration

Weli, S. C., Fink, T., Cetinkaya, C., Prasad, M. S., Pennisi, C. P. & Zachar, V., 2010, In : International Journal of Stem Cells. 3, 2, p. 129-137 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Self-renewal of hESCs is maintained in hypoxia through cooperation of Notch and Shh pathways

Weli, S. C., Simsek, S., Fink, T., Cetinkaya, C., Prasad, M. S. & Zachar, V., 2010, In : Differentiation. 80, Suppl. 1, p. S36, No. P57

Research output: Contribution to journalConference abstract in journalResearch

Stem cells and tissue engineering associated with polyester mesh support device for ischemic cardiomyopathy

Chachques, J. C., Shafy, A., Fink, T., Zachar, V., Bruneval, P. & Carpentier, A. F., 2010, In : European Heart Journal. 31, Suppl. 1, p. 941, No. 5218

Research output: Contribution to journalConference abstract in journalResearchpeer-review

25 Citations (Scopus)

The effect of human embryonic stem cells (hESCs) long-term normoxic and hypoxic cultures on the maintenance of pluripotency

Zachar, V., Prasad, M. S., Weli, S. C., Gabrielsen, A., Petersen, K., Petersen, M. B. & Fink, T., 2010, In : In Vitro Cellular & Developmental Biology - Animal. 46, 3-4, p. 276-283 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2009

Chondrogenic differentiation of human adipose tissue-derived stem cells in micropellet cultures: the effect of oxygen concentration and donor variability

Zachar, V., Pilgaard, L., Lund, P., Duroux, M., Ulrich-Vinther, M., Søballe, K. & Fink, T., 2009, 7th Annual Meeting of the International Federation for Adipose Therapeutics and Science, IFATS 2009, 15-17 October 2009, Daegu, South Korea. p. 113, No. P-28

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearch

72 Citations (Scopus)

Continuous hypoxic culturing maintains activation of Notch and allows long-term propagation of human embryonic stem cells without spontaneous differentiation

Prasad, M. S., Czepiel, M., Cetinkaya, C., Smigielska, K., Weli, S. C., Lysdahl, H., Gabrielsen, A., Petersen, K., Ehlers, N., Fink, T., Minger, S. L. & Zachar, V., 2009, In : Cell Proliferation. 42, 1, p. 63-74

Research output: Contribution to journalJournal articleResearchpeer-review

62 Citations (Scopus)

Effect of growth media and serum replacements on the proliferation and differentiation of adipose-derived stem cells

Lund, P., Pilgaard, L., Crookshanks, M., Fink, T. & Zachar, V., 2009, In : Cytotherapy. 11, 2, p. 189-197

Research output: Contribution to journalJournal articleResearchpeer-review

33 Citations (Scopus)

Effect of oxygen concentration, culture format and donor variability on in vitro chondrogenesis of human adipose tissue-derived stem cells

Pilgaard, L., Lund, P., Duroux, M., Fink, T., Ulrich-Vinter, M., Søballe, K. & Zachar, V., 2009, In : Regenerative Medicine. 4, 4, p. 539-548

Research output: Contribution to journalJournal articleResearchpeer-review

Stem cell therapy following acute myocardial infarction: comparative studies with adipose tissue-derived stem cells and bone marrow-derived stem cells

Rasmussen, J. G., Frøbert, O., Kastrup, J., Fink, T. & Simonsen, U., 2009, PhD Day, 16 January 2009, Aarhus University, Graduate School of Health Sciences, Aarhus, Denmark. Aarhus Universitet, p. 91-92, No. P07.03

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearch

294 Downloads (Pure)

Stem cell therapy following acute myocardial infarction: Comparative studies with adipose tissue-derived stem cells and bone marrow-derived stem cells

Rasmussen, J. G., Frøbert, O., Kastrup, J., Fink, T. & Simonsen, U., 2009.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearch

Open Access
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