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Research Output 2002 2019

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Journal article
2019

Fabrication and characterization of extracellular matrix scaffolds obtained from adipose-derived stem cells

Riis, S., Hansen, A. C., Johansen, L., Lund, K., Pedersen, C., Pitsa, A., Hyldig, K., Zachar, V., Fink, T. & Pennisi, C. P., 9 Jul 2019, In : Methods.

Research output: Contribution to journalJournal articleResearchpeer-review

Stem cells
Scaffolds
Extracellular Matrix
Stem Cells
Wound Healing
2018
2 Citations (Scopus)

Focal adhesion kinase activation is necessary for stretch-induced alignment and enhanced differentiation of myogenic precursor cells

Andersen, J. I., Pennisi, C. P., Fink, T. & Zachar, V., 1 Apr 2018, In : Tissue Engineering. Part A. 24, 7-8, p. 631-640 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Focal Adhesion Protein-Tyrosine Kinases
Adhesion
Chemical activation
Tensile strain
Myoblasts
3 Citations (Scopus)
118 Downloads (Pure)

Hypoxia enhances differentiation of adipose tissue-derived stem cells toward the smooth muscle phenotype

Wang, F., Zachar, V., Pennisi, C. P., Fink, T., Maeda, Y. & Emmersen, J., 2018, In : International Journal of Molecular Sciences . 19, 2, 12 p., 517.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
adipose tissues
smooth muscle
phenotype
stem cells
hypoxia
3 Citations (Scopus)
78 Downloads (Pure)

Pigmentation is associated with stemness hierarchy of progenitor cells within cultured limbal epithelial cells

Liu, L., Nielsen, F. M., Emmersen, J., Bath, C., Hjortdal, J. Ø., Riis, S., Fink, T., Pennisi, C. P. & Zachar, V., Sep 2018, In : Stem Cells. 36, 9, p. 1411-1420 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Pigmentation
Stem Cells
Epithelial Cells
Adenosine Triphosphate
Keratin-3
2017
7 Citations (Scopus)
175 Downloads (Pure)

Hypoxia enhances the wound-healing potential of adipose-derived stem cells in a novel human primary keratinocyte-based scratch assay

Riis, S., Newman, R., Ipek, H., Andersen, J. I., Kuninger, D., Boucher, S., Vemuri, M. C., Pennisi, C. P., Zachar, V. & Fink, T., 2017, In : International Journal of Molecular Medicine. 39, 3, p. 587-594

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Keratinocytes
Wound Healing
Stem Cells
Calcium
Conditioned Culture Medium
2 Citations (Scopus)
233 Downloads (Pure)

Maintaining RNA integrity for transcriptomic profiling of ex vivo cultured limbal epithelial stem cells after fluorescence-activated cell sorting (FACS)

Liu, L., Nielsen, F. M., Riis, S. E., Emmersen, J., Fink, T., Hjortdal, J. Ø., Bath, C. & Zachar, V., 12 Dec 2017, In : Biological Procedures Online. 19, 7 p., 15.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Stem cells
Sorting
Flow Cytometry
Stem Cells
Epithelial Cells
2016
19 Citations (Scopus)

Comparative analysis of media and supplements on initiation and expansion of adipose-derived stem cells

Riis, S., Nielsen, F. M., Pennisi, C. P., Zachar, V. & Fink, T., 2016, In : Stem Cells Translational Medicine. 5, 3, p. 314-324

Research output: Contribution to journalJournal articleResearchpeer-review

Stem Cells
Blood Platelets
Serum
Eagles
Serum-Free Culture Media
4 Citations (Scopus)
187 Downloads (Pure)

Discrete adipose-derived stem cell subpopulations may display differential functionality after in vitro expansion despite convergence to a common phenotype distribution

Nielsen, F. M., Riis, S. E., Andersen, J. I., Lesage, R., Fink, T., Pennisi, C. P. & Zachar, V., 2016, In : Stem Cell Research & Therapy. 7, 13 p., 177.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Stem cells
Stem Cells
Phenotype
Flow cytometry
Wound Healing
15 Citations (Scopus)

Environmental chemicals modulate polar bear (Ursus maritimus) peroxisome proliferator-activated receptor gamma (PPARG) and adipogenesis in vitro

Routti, H., Lille-Langøy, R., Berg, M. K., Fink, T., Harju, M., Kristiansen, K., Rostkowski, P., Rusten, M., Sylte, I., Øygarden, L. & Goksøyr, A., 2016, In : Environmental Science & Technology. 50, 19, p. 10708-10720

Research output: Contribution to journalJournal articleResearchpeer-review

PPAR gamma
bear
Tissue
Stem cells
Impurities
18 Citations (Scopus)
294 Downloads (Pure)
Open Access
File
2014
39 Citations (Scopus)

Comparison of human adipose-derived stem cells and bone marrow-derived stem cells in a myocardial infarction model

Rasmussen, J., Frøbert, O., Holst-Hansen, C., Kastrup, J., Baandrup, U., Zachar, V., Fink, T. & Simonsen, U., 2014, In : Cell Transplantation. 23, 2, p. 195-206

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

From cases to projects in problem-based medical education

Stentoft, D., Duroux, M., Fink, T. & Emmersen, J., 2014, In : Journal of Problem Based Learning in Higher Education. 2, 1, p. 45-62

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
6 Citations (Scopus)

Moderate hypoxia influences potassium outward currents in adipose-derived stem cells

Prasad, M. S., Zachar, V., Fink, T. & Pennisi, C. P., 2014, In : P L o S One. 9, 8, 10 p., e104912.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
2 Citations (Scopus)

Technical brief: Optimized pipeline for isolation of high-quality RNA from corneal cell subpopulations

Søndergaard, C. B., Fink, T., Vorum, H., Hjortdal, J. & Zachar, V., 2014, In : Molecular Vision. 20, p. 797-803

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
11 Citations (Scopus)

Uniaxial cyclic strain enhances adipose-derived stem cell fusion with skeletal myocytes

Andersen, J. I., Juhl, M., Nielsen, T., Emmersen, J., Fink, T., Zachar, V. & Pennisi, C. P., 2014, In : Biochemical and Biophysical Research Communications. 450, 2, p. 1083-1088

Research output: Contribution to journalJournal articleResearchpeer-review

2013
28 Citations (Scopus)

Development of cardiac support bioprostheses for ventricular restoration and myocardial regeneration

Shafy, A., Fink, T., Zachar, V., Lila, N., Carpentier, A. & Chachques, J. C., 2013, In : European Journal of Cardio-Thoracic Surgery. 43, 6, p. 1211-1219

Research output: Contribution to journalJournal articleResearchpeer-review

15 Citations (Scopus)

Hypoxia is a key regulator of limbal epithelial stem cell growth and differentiation

Søndergaard, C. B., Yang, S., Muttuvelu, D. V., Fink, T., Emmersen, J., Vorum, H., Hjortdal, J. Ø. & Zachar, V., May 2013, In : Stem Cell Research. 10, 3, p. 349–360 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cell Differentiation
Stem Cells
Epithelial Cells
Oxygen
Growth
2012
20 Citations (Scopus)

Activation of protease-activated receptor 2 induces VEGF independently of HIF-1

Rasmussen, J., Riis, S. E., Frøbert, O., Yang, S., Kastrup, J., Zachar, V., Simonsen, U. & Fink, T., 25 Sep 2012, In : P L o S One. 7, 9, p. Article No. e46087

Research output: Contribution to journalJournal articleResearchpeer-review

29 Citations (Scopus)

Defined xenogeneic-free and hypoxic environment provides superior conditions for long-term expansion of human adipose-derived stem cells

Yang, S., Pilgaard, L., Chase, L. G., Boucher, S., Vemuri, M. C., Fink, T. & Zachar, V., 2012, In : Tissue Engineering. Part C. Methods. 18, 8, p. 593-602

Research output: Contribution to journalJournal articleResearchpeer-review

24 Citations (Scopus)

Patterned poly(lactic acid) films support growth and spontaneous multilineage gene expression of adipose-derived stem cells

Nielsen, S. F., Petersen, M., Fojan, P., Gurevich, L., Fink, T., Pennisi, C. P. & Zachar, V., 2012, In : Colloids and Surfaces B: Biointerfaces. 93, p. 92-99

Research output: Contribution to journalJournal articleResearchpeer-review

2011
40 Citations (Scopus)

Adipogenic differentiation of human mesenchymal stem cells

Fink, T. & Zachar, V., 2011, In : Methods in Molecular Biology. 698, p. 243-251, kap. 19

Research output: Contribution to journalJournal articleResearchpeer-review

28 Citations (Scopus)

Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation in vitro

Fink, T., Rasmussen, J., Emmersen, J., Pilgaard, L., Fahlman, Å., Brunberg, S., Josefsson, J., Arnemo, J. M., Zachar, V., Swenson, J. E. & Fröbert, O., 2011, In : Stem Cell Research. 7, 1, p. 89-95

Research output: Contribution to journalJournal articleResearchpeer-review

34 Citations (Scopus)

Hypoxia and adipose-derived stem cell-based tissue regeneration and engineering

Zachar, V., Duroux, M., Emmersen, J., Rasmussen, J. G., Pennisi, C. P., Yang, S. & Fink, T., 2011, In : Expert Opinion on Biological Therapy. 11, 6, p. 775-786

Research output: Contribution to journalJournal articleResearchpeer-review

26 Citations (Scopus)

Isolation and expansion of adipose-derived stem cells for tissue engineering

Fink, T., Rasmussen, J. G., Lund, P., Pilgaard, L., Søballe, K. & Zachar, V., 2011, In : Frontiers in Bioscience. E3, 1, p. 256-263 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cell Engineering
Tissue Engineering
Stem cells
Tissue engineering
Stem Cells
30 Citations (Scopus)

Isolation and growth of adipose tissue-derived stem cells

Zachar, V., Rasmussen, J. & Fink, T., 2011, In : Methods in Molecular Biology. 698, p. 37-49, kap. 4

Research output: Contribution to journalJournal articleResearchpeer-review

52 Citations (Scopus)

Nanoscale topography reduces fibroblast growth, focal adhesion size and migration-related gene expression on platinum surfaces

Pennisi, C. P., Dolatshahi-Pirouz, A., Foss, M., Chevallier, J., Fink, T., Zachar, V., Besenbacher, F. & Yoshida, K., 2011, In : Colloids and Surfaces B: Biointerfaces. 85, 2, p. 189-197

Research output: Contribution to journalJournal articleResearchpeer-review

69 Citations (Scopus)

Prolonged hypoxic culture and trypsinization increase the pro-angiogenic potential of human adipose tissue-derived stem cells

Rasmussen, J. G., Frøbert, O., Pilgaard, L., Kastrup, J., Simonsen, U., Zachar, V. & Fink, T., 2011, In : Cytotherapy. 13, 3, p. 318-328 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2010
3 Citations (Scopus)

Notch and Hedgehog signaling cooperate to maintain self-renewal of human embryonic stem cells exposed to low oxygen concentration

Weli, S. C., Fink, T., Cetinkaya, C., Prasad, M. S., Pennisi, C. P. & Zachar, V., 2010, In : International Journal of Stem Cells. 3, 2, p. 129-137 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

25 Citations (Scopus)

The effect of human embryonic stem cells (hESCs) long-term normoxic and hypoxic cultures on the maintenance of pluripotency

Zachar, V., Prasad, M. S., Weli, S. C., Gabrielsen, A., Petersen, K., Petersen, M. B. & Fink, T., 2010, In : In Vitro Cellular & Developmental Biology - Animal. 46, 3-4, p. 276-283 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2009
72 Citations (Scopus)

Continuous hypoxic culturing maintains activation of Notch and allows long-term propagation of human embryonic stem cells without spontaneous differentiation

Prasad, M. S., Czepiel, M., Cetinkaya, C., Smigielska, K., Weli, S. C., Lysdahl, H., Gabrielsen, A., Petersen, K., Ehlers, N., Fink, T., Minger, S. L. & Zachar, V., 2009, In : Cell Proliferation. 42, 1, p. 63-74

Research output: Contribution to journalJournal articleResearchpeer-review

62 Citations (Scopus)

Effect of growth media and serum replacements on the proliferation and differentiation of adipose-derived stem cells

Lund, P., Pilgaard, L., Crookshanks, M., Fink, T. & Zachar, V., 2009, In : Cytotherapy. 11, 2, p. 189-197

Research output: Contribution to journalJournal articleResearchpeer-review

33 Citations (Scopus)

Effect of oxygen concentration, culture format and donor variability on in vitro chondrogenesis of human adipose tissue-derived stem cells

Pilgaard, L., Lund, P., Duroux, M., Fink, T., Ulrich-Vinter, M., Søballe, K. & Zachar, V., 2009, In : Regenerative Medicine. 4, 4, p. 539-548

Research output: Contribution to journalJournal articleResearchpeer-review

37 Citations (Scopus)

Transcriptional signature of human adipose tissue-derived stem cells (hASCs) preconditioned for chondrogenesis in hypoxic conditions

Pilgaard, L., Lund, P., Duroux, M., Lockstone, H., Taylor, J., Emmersen, J., Fink, T., Ragoussis, J. & Zachar, V., 2009, In : Experimental Cell Research. 315, 11, p. 1937-1952

Research output: Contribution to journalJournal articleResearchpeer-review

2008
30 Citations (Scopus)

Comparative analysis of highly defined proteases for the isolation of adipose tissue-derived stem cells

Pilgaard, L., Lund, P., Rasmussen, J. G., Fink, T. & Zachar, V., 2008, In : Regenerative Medicine. 3, 5, p. 705-715

Research output: Contribution to journalJournal articleResearchpeer-review

96 Citations (Scopus)

Instability of standard PCR reference genes in adipose-derived stem cells during propagation, differentiation and hypoxic exposure

Fink, T., Lund, P., Pilgaard, L., Rasmussen, J. G., Duroux, M. & Zachar, V., 2008, In : BMC Molecular Biology. 9, 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2006

Cases: en ny studiemetode på Medicin med Industriel Specialisering

Ståhl, C., Fink, T. & Dinesen, B., 2006, In : UGlen. 2006, 7, p. 8

Research output: Contribution to journalJournal articleCommunication

24 Citations (Scopus)

Derivation and characterization of four new human embryonic stem cell lines: the Danish experience

Lysdahl, H., Gabrielsen, A., Minger, S. L., Patel, M. J., Fink, T., Petersen, K., Ebbesen, P. & Zachar, V., 2006, In : Reproductive BioMedicine Online. 12, 1, p. 119-126

Research output: Contribution to journalJournal articleResearchpeer-review

32 Citations (Scopus)

Evaluation of transfection protocols for unmodified and modified peptide nucleic acid (PNA) oligomers

Rasmussen, F. W., Bendifallah, N., Zachar, V., Shiraishi, T., Fink, T., Ebbesen, P., Nielsen, P. E. & Koppelhus, U., 2006, In : Oligonucleotides. 16, 1, p. 43-57

Research output: Contribution to journalJournal articleResearchpeer-review

7 Citations (Scopus)

Hypoxic treatment inhibits insulin-induced chondrogenesis of ATDC5 cells despite upregulation of DEC1

Chen, L., Fink, T., Ebbesen, P. & Zachar, V., 2006, In : Connective Tissue Research. 47, 3, p. 119-123

Research output: Contribution to journalJournal articleResearchpeer-review

98 Citations (Scopus)

Inhibition of osteoblast differentiation but not adipocyte differentiation of mesenchymal stem cells by sera obtained from aged females

Abdallah, B. B., Haack-Sørensen, M., Fink, T. & Kassem, M., 2006, In : Bone. 39, 1, p. 181-188

Research output: Contribution to journalJournal articleResearchpeer-review

18 Citations (Scopus)

Optimized chondrogenesis of ATCD5 cells through sequential regulation of oxygen conditions

Chen, L., Fink, T., Ebbesen, P. & Zachar, V., 2006, In : Tissue Engineering. Part C. Methods. 12, 3, p. 559-567

Research output: Contribution to journalJournal articleResearchpeer-review

19 Citations (Scopus)

Temporal transcriptome of mouse ATDC5 chondroprogenitors differentiating under hypoxic conditions

Chen, L., Fink, T., Ebbesen, P. & Zachar, V., 2006, In : Experimental Cell Research. 312, 10, p. 1727-1744

Research output: Contribution to journalJournal articleResearchpeer-review

2005
33 Citations (Scopus)

Quantitative transcriptional profiling of ATDC5 mouse progenitor cells during chondrogenesis

Chen, L., Fink, T., Zhang, X-Y., Ebbesen, P. & Zachar, V., 2005, In : Differentiation. 73, 7, p. 350-363

Research output: Contribution to journalJournal articleResearchpeer-review

35 Citations (Scopus)

Transcriptional regulation of plasminogen activator inhibitor-1 expression by insulin-like growth factor-1 via MAP kinases and hypoxia-inducible factor-1 in HepG2 cells

Dimova, E. Y., Möller, U., Herzig, S., Fink, T., Zachar, V., Ebbesen, P. & Kietzmann, T., 2005, In : Thrombosis and Haemostasis. 93, 6, p. 1176-1184

Research output: Contribution to journalJournal articleResearchpeer-review

2004
130 Citations (Scopus)

Induction of adipocyte-like phenotype in human mesenchymal stem cells by hypoxia

Fink, T., Abildtrup, L. A., Fogd, K., Abdallah, B. M., Kassem, M., Ebbesen, P. & Zachar, V., 2004, In : Stem Cells. 22, 7, p. 1346-1355

Research output: Contribution to journalJournal articleResearchpeer-review

2003
2 Citations (Scopus)

Expression of butyrate response factor 1 in HTLV-1-transformed cells and its transactivation by tax protein

Li, B., Fink, T., Ebbesen, P., Liu, X. & Zachar, V., 2003, In : Archives of Virology. 148, 9, p. 1787-1804 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

29 Citations (Scopus)
6 Citations (Scopus)

Transcriptional activation of immediate-early gene ETR101 by human T-cell leukaemia virus type I Tax

Chen, L., Ma, S., Li, B., Fink, T., Zachar, V., Takahashi, M., Cuttichia, J., Tsui, L-C., Ebbesen, P. & Liu, X., 2003, In : Journal of General Virology. 84, p. 3203-3214

Research output: Contribution to journalJournal articleResearchpeer-review

2002
113 Citations (Scopus)

Identification of a tightly regulated hypoxia-response element in the promoter of human plasminogen activator inhibitor-1

Fink, T., Kazlauskas, A., Poellinger, L., Ebbesen, P. & Zachar, V., 2002, In : Blood. 99, 6, p. 2077-2083

Research output: Contribution to journalJournal articleResearchpeer-review

25 Citations (Scopus)

Role of placental cytokines in transcriptional modulation of HIV type 1 in the isolated villous trophoblast

Zachar, V., Fink, T., Koppelhus, U. & Ebbesen, P., 2002, In : AIDS Research and Human Retroviruses. 18, 12, p. 839-847

Research output: Contribution to journalJournal articleResearchpeer-review