• Fredrik Bajers Vej 3, B, 1-216

    9220 Aalborg Ø

    Denmark

20072021
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Research Output 2007 2019

2019
Hepcidins
Ficus
PC12 Cells
Iron
Messenger RNA
1 Citation (Scopus)
Hepcidins
PC12 Cells
Iron
Messenger RNA
Deferoxamine
1 Downloads (Pure)

Impairment of the Developing Human Brain in Iron Deficiency: Correlations to Findings in Experimental Animals and Prospects for Early Intervention Therapy

Markova, V., Holm, C., Pinborg, A. B., Thomsen, L. L. & Moos, T., 14 Aug 2019, In : Pharmaceuticals. 12, 3, 16 p., 120.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
File
Secondary Prevention
Iron
Brain
Transferrin Receptors
Sus scrofa
8 Citations (Scopus)

Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo

Johnsen, K. B., Bak, M., Melander, F., Thomsen, M. S., Burkhart, A., Kempen, P. J., Andresen, T. L. & Moos, T., 10 Feb 2019, In : Journal of Controlled Release. 295, p. 237-249 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Transferrin Receptors
Blood-Brain Barrier
Gold
Nanoparticles
Antibodies

Targeting the transferrin receptor for brain drug delivery

Bendix Johnsen, K., Burkhart, A., Bohn Thomsen, L., Andresen, T. L. & Moos, T., 1 Oct 2019, In : Progress in Neurobiology. 181, 101665.

Research output: Contribution to journalReview articleResearchpeer-review

Transferrin Receptors
Blood-Brain Barrier
Brain
Pharmaceutical Preparations
Nanomedicine
2018
12 Citations (Scopus)
538 Downloads (Pure)

Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles

Johnsen, K. B., Bak, M., Kempen, P. J., Melander, F., Burkhart, A., Thomsen, M. S., Nielsen, M. S., Moos, T. & Andresen, T. L., 2018, In : Theranostics. 8, 12, p. 3416-3436

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Transferrin Receptors
Antibody Affinity
Gold
Nanoparticles
Nanomedicine
3 Citations (Scopus)
74 Downloads (Pure)

Iron deficiency and iron treatment in the fetal developing brain: a pilot study introducing an experimental rat model

Moos, T., Skjørringe, T. & Thomsen, L. L., 22 Jun 2018, In : Reproductive Health. 15, Suppl. 1, p. 117-120 93.

Research output: Contribution to journalConference article in JournalResearchpeer-review

Open Access
File
Theoretical Models
Iron
Brain
Therapeutics
Mothers
12 Citations (Scopus)

On the use of liposome controls in studies investigating the clinical potential of extracellular vesicle-based drug delivery systems: A commentary

Johnsen, K. B., Gudbergsson, J. M., Duroux, M., Moos, T., Andresen, T. L. & Simonsen, J. B., 2018, In : Journal of Controlled Release. 269, p. 10-14

Research output: Contribution to journalReview articleResearchpeer-review

Drug Delivery Systems
Liposomes
Nanoparticles
Pharmaceutical Preparations
Therapeutic Uses
4 Citations (Scopus)

The endo-lysosomal system of brain endothelial cells is influenced by astrocytes in vitro

Toth, A. E., Siupka, P., P Augustine, T. J., Venø, S. T., Thomsen, L. B., Moos, T., Lohi, H. T., Madsen, P., Lykke-Hartmann, K. & Nielsen, M. S., Nov 2018, In : Molecular Neurobiology. 55, 11, p. 8522-8537 16 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Astrocytes
Endothelial Cells
Brain
Blood-Brain Barrier
Transcytosis
2017
10 Citations (Scopus)

Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells

Siupka, P., Hersom, M. N. S., Lykke-Hartmann, K., Johnsen, K. B., Thomsen, L. B., Andresen, T. L., Moos, T., Abbott, N. J., Brodin, B. & Nielsen, M. S., 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 7, p. 2598–2613

Research output: Contribution to journalJournal articleResearchpeer-review

IGF Type 2 Receptor
Cations
Endothelial Cells
Brain
Transferrin Receptors
13 Citations (Scopus)
Endothelial cells
Pericytes
Blood-Brain Barrier
Basement Membrane
Brain
36 Citations (Scopus)
44 Downloads (Pure)

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma

Johnsen, K. B., Burkhart, A., Melander, F., Kempen, P. J., Vejlebo, J. B., Siupka, P., Nielsen, M. S., Andresen, T. L. & Moos, T., 1 Dec 2017, In : Scientific Reports. 7, 13 p., 10396.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Transferrin Receptors
Blood-Brain Barrier
Brain
Endothelium
Transcytosis
12 Citations (Scopus)
153 Downloads (Pure)

The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury

Xiang, J., Routhe, L. J., Andrew Wilkinson, D., Hua, Y., Moos, T., Xi, G. & Keep, R. F., 28 Mar 2017, In : Fluids and Barriers of the CNS. 14, 13 p., 8.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
File
Choroid Plexus
Stroke
Wounds and Injuries
Hemorrhage
Cerebral Hemorrhage
32 Citations (Scopus)

The vascular basement membrane in the healthy and pathological brain

Thomsen, M. S., Routhe, L. J. & Moos, T., Oct 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 10, p. 3300-3317

Research output: Contribution to journalReview articleResearchpeer-review

Basement Membrane
Blood Vessels
Brain
Pericytes
Endothelial Cells
2 Citations (Scopus)
Erythropoietin
Transfection
Endothelial Cells
Brain
Proteins
2016

A triple co-culture model of the blood-brain barrier using primary porcine brain endothelial cells, porcine pericytes and porcine astrocytes

Thomsen, L. B., Larsen, A. B. & Moos, T., 2016, IPC No. C12N 5/071 (2010.01), C12N 5/079 (2010.01), G01N 33/50 (2006.01), Patent No. WO/2016/202343 , 22 Dec 2016, Priority date 16 Jun 2016, Priority No. PCT/DK2016/050190

Research output: PatentResearch

Open Access

Behandlingen af Alzheimers sygdom: det er vanskeligt at forstå, hvordan passiv immunterapi virker

Moos, T. & Thomsen, M. S., 2016, In : Ugeskrift for Laeger. 178, 15, p. 1457

Research output: Contribution to journalComment/debateResearch

19 Citations (Scopus)

Evaluation of electroporation-induced adverse effects on adipose-derived stem cell exosomes

Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Christiansen, G., Gurevich, L., Moos, T. & Duroux, M., 2016, In : Cytotechnology. 68, 5, p. 2125–2138

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Exosomes
Electroporation
Stem Cells
Glioblastoma
Pharmaceutical Preparations

Expression and deposition of basement membrane proteins by brain capillary endothelial cells in a primary murine model of the blood-brain barrier

Thomsen, M. S., Birkelund, S., Larsen, A. B., Stensballe, A. & Moos, T., 2016, Final Programme, 19th International Symposium on Signal Transduction at the Blood-Brain Barriers, 14-16 September 2016, Copenhagen, Denmark. University of Copenhagen, p. 37 P-12

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

25 Citations (Scopus)

Expression of iron-related proteins at the neurovascular unit supports reduction and reoxidation of iron for transport through the blood-brain barrier

Burkhart, A., Skjørringe, T., Johnsen, K. B., Siupka, P., Thomsen, L. B., Nielsen, M. S., Thomsen, L. L. & Moos, T., 2016, In : Molecular Neurobiology. 53, 10, p. 7237-7253

Research output: Contribution to journalJournal articleResearchpeer-review

Blood-Brain Barrier
Iron
Ceruloplasmin
Brain
Endothelial Cells

Gene delivery of the therapeutic polypeptide erythropoietin to primary brain capillary endothelial cells for protein secretion

Larsen, A. B. & Moos, T., 2016, Final Programme, 19th International Symposium on Signal Transduction at the Blood-Brain Barriers, 14-16 September 2016, Copenhagen, Denmark. University of Copenhagen, p. 25 O-5

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

5 Citations (Scopus)
133 Downloads (Pure)

Geographical variation in antipsychotic drug use in elderly patients with dementia: a nationwide study

Zakarias, J. K., Jensen-Dahm, C., Nørgaard, A., Stevnsborg, L., Gasse, C., Andersen, B. G., Søren, J., Waldorff, F. B., Moos, T. & Waldemar, G., 2016, In : Journal of Alzheimer's Disease. 54, 3, p. 1183-1192

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Antipsychotic Agents
Dementia
Denmark
Behavioral Symptoms
Caregivers
121 Downloads (Pure)

Metal-dependent regulation of ATP7A and ATP7B in fibroblast cultures

Lenartowicz, M., Moos, T., Ogórek, M., Jensen, T. G. & Møller, L. B., 2016, In : Frontiers in Molecular Neuroscience. 9, 68.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Copper
Fibroblasts
Metals
Menkes Kinky Hair Syndrome
Hepatolenticular Degeneration

Proteomics-driven design of endothelial stress-based protein array for disease prognostics: applied to plasma and cerebrospinal fluid

Kastaniegaard, K., Jørgensen, M. M., Bæk, R., Sejrbæk, T., Wiwie, C., Baumbach, J., Zachar, V., Moos, T., Nielsen, S., Nieland, J. D., Cotton, F., Guttmann, C., Illes, Z. & Stensballe, A., 2016, In : Journal of Extracellular Vesicles. 5, Suppl. 1, p. 4 1 p., OW2.2.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier

Moos, T., Routhe, L. J., Birkelund, S., Burkhart, A., Stensballe, A. & Thomsen, M. S., 2016, 46th Annual Meeting of the Society for Neuroscience, Neuroscience 2016, 12-16 November 2016, San Diego, CA, USA. Society for Neuroscience, 140.10 / U1

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

Open Access
6 Citations (Scopus)

Targeted vascular drug delivery in cerebral cancer

Humle, N., Johnsen, K. B., Arendt, G. A., Nielsen, R. P., Moos, T. & Thomsen, L. B., 2016, In : Current Pharmaceutical Design. 22, 35, p. 5487-5504

Research output: Contribution to journalReview articleResearchpeer-review

Glioblastoma
Blood Vessels
Pharmaceutical Preparations
Neoplasms
Brain Neoplasms

Targeting immunoliposomes to transferrin receptors on brain capillary endothelial cells as a mean for cargo transport across the blood-brain barrier

Johnsen, K. B., Larsen, A. B., Bruun, J., Siupka, P., Nielsen, M. S., Andresen, T. L. & Moos, T., 2016, Final Programme, 19th International Symposium on Signal Transduction at the Blood-Brain Barriers, 14-16 September 2016, Copenhagen, Denmark. University of Copenhagen, p. 51 P-51

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

Targeting immunoliposomes to transferrin receptors on brain capillary endothelial cells as a mean for cargo transport across the blood-brain barrier

Moos, T., Johnsen, K. B., Burkhart, A., Bruun, J., Siupka, P., Nielsen, M. S. & Andresen, T., 2016, 46th Annual Meeting of the Society for Neuroscience, Neuroscience 2016, 12-16 November 2016, San Diego, CA, USA. Society for Neuroscience, 140.13 / U4

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

Open Access

Trafficking of Transferrin Receptor in primary porcine brain endothelial cells and its implication for drug delivery to the brain

Siupka, P., Thomsen, L. B., Lykke-Hartmann, K., Moos, T. & Nielsen, M. S., 2016, Final Programme, 19th International Symposium on Signal Transduction at the Blood-Brain Barriers, 14-16 September 2016, Copenhagen, Denmark. University of Copenhagen, p. 27 O-9

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

Vesicular transport in brain microvascular endothelial cells

Toth, A., Siupka, P., Pulikotial, A. T., Thomsen, L. B., Lohi, H. T., Lykke-Hartmann, K., Moos, T., Madsen, P. & Nielsen, M. S., 2016, Final Programme, 19th International Symposium on Signal Transduction at the Blood-Brain Barriers, 14-16 September 2016, Copenhagen, Denmark. University of Copenhagen, p. 42-43 P-29

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

2015

A novel transgenic mouse line co-expressing alpha-synuclein and p25alpha displays increased oligomer formation

Lassen, L. B., Jensen, P. H., Betzer, C. & Moos, T., 2015, 45th Annual Meeting of the Society for Neuroscience, Neuroscience 2015, 17-21 October 2015, Chicago, IL, USA. Society for Neuroscience, p. No. 647.10

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

Open Access
50 Citations (Scopus)
211 Downloads (Pure)

A triple culture model of the blood-brain barrier using porcine brain endothelial cells, astrocytes and pericytes

Thomsen, L. B., Burkhart, A. & Moos, T., 2015, In : PLOS ONE. 10, 8, 16 p., e0134765.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Pericytes
blood-brain barrier
astrocytes
Endothelial cells
Blood-Brain Barrier
50 Citations (Scopus)
210 Downloads (Pure)
Open Access
File
3 Citations (Scopus)

Handling iron in restorative neuroscience

Routhe, L. J. & Moos, T., 2015, In : Neural Regeneration Research. 10, 10, p. 1558-1559

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
24 Citations (Scopus)

Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons

Thomsen, M. S., Andersen, M. V., Christoffersen, P. R., Jensen, M. D., Lichota, J. & Moos, T., 2015, In : Neurobiology of Disease. 81, p. 108-118

Research output: Contribution to journalJournal articleResearchpeer-review

Repercussions of glioblastoma multiforme on the blood-brain barrier

Humle, N. H., Thomsen, L. B. & Moos, T., 2015, In : Clinical Neuropathology. 34, 3, p. 149

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access
24 Citations (Scopus)

Targeted drug delivery to the brain using magnetic nanoparticles

Thomsen, L. B., Thomsen, M. S. & Moos, T., 2015, In : Therapeutic Delivery. 6, 10, p. 1145-1155

Research output: Contribution to journalJournal articleResearchpeer-review

Nanoparticles
Blood-Brain Barrier
Endothelial Cells
Brain
Pharmaceutical Preparations

The invasive nature of primary GBM cell lines: importance of paracrine signaling

Pilgaard, L., Elbæk, K. J., Gudbergsson, J. M., Stensballe, A., Moos, T., Zachar, V., Agger, R. & Doroux, M., 2015, In : Clinical Neuropathology. 34, 3, p. 159

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access
20 Citations (Scopus)
239 Downloads (Pure)

Transfection of brain capillary endothelial cells in primary culture with defined blood-brain barrier properties

Larsen, A. B., Thomsen, L. B., Thomsen, M. S., Lichota, J., Fazakas, C., Krizbai, I. & Moos, T., 2015, In : Fluids and Barriers of the CNS. 12, 1, 14 p., 19.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Blood-Brain Barrier
Transfection
Endothelial Cells
Brain
Astrocytes
2014
8 Citations (Scopus)

Accessing targeted nanoparticles to the brain: the vascular route

Burkhart, A., Azizi, M., Thomsen, M. S., Thomsen, L. B. & Moos, T., 2014, In : Current Medicinal Chemistry. 21, 36, p. 4092-4099

Research output: Contribution to journalJournal articleResearchpeer-review

269 Citations (Scopus)

A comprehensive overview of exosomes as drug delivery vehicles: endogenous nanocarriers for targeted cancer therapy

Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T. & Duroux, M., 2014, In : B B A - Reviews on Cancer. 1846, 1, p. 75–87

Research output: Contribution to journalReview articleResearchpeer-review

Ceruloplasmin is expressed by brain pericytes

Moos, T. & Larsen, A. B., 2014, Annual Meeting of the Society for Neuroscience, Neuroscience 2014, 15-19 November 2014, Washington, DC, USA. p. Poster No. 739.01/QQ4

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearch

16 Citations (Scopus)

Cripto-1 expression in glioblastoma multiforme

Pilgaard, L., Mortensen, J. H., Henriksen, M., Olesen, P., Sørensen, P., Laursen, R. J., Vyberg, M., Agger, R., Zachar, V., Moos, T. & Duroux, M., 2014, In : Brain Pathology. 24, 4, p. 360–370

Research output: Contribution to journalJournal articleResearchpeer-review

16 Citations (Scopus)

Cripto-1 expression in glioblastoma multiforme

Duroux, M., Olesen, P., Pilgaard, L., Henriksen, M., Mortensen, J. H., Sørensen, P., Laursen, R. J., Vyberg, M., Agger, R., Zachar, V. & Moos, T., 2014, Proceedings of the 5th Disputationes : Addressing Organ Regeneration and Tissue Repair by Artificial Supports, 12-13 May 2014, Aalborg, Denmark.

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearch

Gene delivery of therapeutic polypeptides to brain capillary endothelial cells for protein secretion

Larsen, A. B., Thomsen, L. B. & Moos, T., 2014.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

60 Citations (Scopus)

Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration

Andersen, H. H., Johnsen, K. B. & Moos, T., 2014, In : Cellular and Molecular Life Sciences. 71, 9, p. 1607-1622

Research output: Contribution to journalReview articleResearchpeer-review

Open Access

Iron uptake and transport at the blood-brain barrier

Larsen, A. B., Thomsen, L. B. & Moos, T., 2014.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

2013

A decrease in neuronal ferroportin accompanies chronic brain inflammation with iron deposition

Andersen, M. V., Christoffersen, P. R., Jensen, M. D., Lichota, J. & Moos, T., 2013, In : American Journal of Hematology. 88, 5, E162, No. 206.

Research output: Contribution to journalConference abstract in journalResearchpeer-review