Mads Toft Søndergaard

  • Fredrik Bajers Vej 7, H, 3536

    9220 Aalborg

    Denmark

20102019
If you made any changes in Pure these will be visible here soon.

Research Output 2010 2019

  • 12 Journal article
  • 3 Conference abstract for conference
Filter
Journal article
2019
4 Citations (Scopus)
105 Downloads (Pure)

Ca2+ dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains

Brohus, M., Søndergaard, M. T., Chen, W. S. R., Van Petegem, F. & Overgaard, M. T., 18 Jan 2019, In : Biochemical Journal. 476, 2, p. 193-209

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Ryanodine Receptor Calcium Release Channel
Calmodulin
Fluorescence Polarization
Sensors
Clamping devices
1 Citation (Scopus)

Diminished inhibition and facilitated activation of RyR2-mediated Ca2+ release is a common defect of arrhythmogenic calmodulin mutations

Søndergaard, M. T., Liu, Y., Brohus, M., Guo, W., Nani, A., Carvajal, C., Fill, M., Overgaard, M. T. & Chen, S. R. W., Nov 2019, In : F E B S Journal. 286, 22, p. 4554-4578

Research output: Contribution to journalJournal articleResearchpeer-review

Ryanodine Receptor Calcium Release Channel
Calmodulin
Mutation
HEK293 Cells
Cardiac Arrhythmias

Role of cardiac ryanodine receptor calmodulin-binding domains in mediating the action of arrhythmogenic calmodulin N-domain mutation N54I

Søndergaard, M. T., Liu, Y., Guo, W., Wei, J., Wang, R., Brohus, M., Overgaard, M. T. & Chen, S. R. W., 25 Nov 2019, In : The FEBS Journal.

Research output: Contribution to journalJournal articleResearchpeer-review

Ryanodine Receptor Calcium Release Channel
Calmodulin
Mutation
HEK293 Cells
2017
13 Citations (Scopus)

The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+-binding but not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor

Søndergaard, M. T., Liu, Y., Larsen, K. T., Nani, A., Tian, X., Holt, C., Wang, R., Wimmer, R., Van Petegem, F., Fill, M., Chen, S. R. W. & Overgaard, M. T., Jan 2017, In : Journal of Biological Chemistry. 292, p. 1385-1395 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Ryanodine Receptor Calcium Release Channel
Calmodulin
Mutation
2016
21 Citations (Scopus)

Epigallocatechin gallate remodels overexpressed functional amyloids in pseudomonas aeruginosa and increases biofilm susceptibility to antibiotic treatment

Stenvang, M. R., Dueholm, M. S., Vad, B. S., Seviour, T., Zeng, G., Geifman-Shochat, S., Søndergaard, M. T., Christiansen, G., Meyer, R. L., Kjelleberg, S., Nielsen, P. H. & Otzen, D. E., 16 Dec 2016, In : The Journal of Biological Chemistry. 291, 51, p. 26540-26553 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Biofilms
Amyloid
Pseudomonas aeruginosa
Anti-Bacterial Agents
Quorum Sensing
2015
27 Citations (Scopus)

Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-Mediated Ca2+ Release

Søndergaard, M. T., Tian, X., Liu, Y., Wang, R., Chazin, W. J., Chen, S. R. W. & Overgaard, M. T., 23 Oct 2015, In : Journal of Biological Chemistry. 290, 43, p. 26151-26162 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Ryanodine Receptor Calcium Release Channel
Calmodulin
Chemical activation
Mutation
Long QT Syndrome
24 Citations (Scopus)

Calmodulin mutations causing catecholaminergic polymorphic ventricular tachycardia confer opposing functional and biophysical molecular changes

Søndergaard, M. T., Sorensen, A. B., Skov, L. L., Kjaer-Sorensen, K., Bauer, M. C., Nyegaard, M., Linse, S., Oxvig, C. & Overgaard, M. T., 14 Jan 2015, In : F E B S Journal. 282, 4, p. 803-816 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Calmodulin
Mutation
Zebrafish
Messenger RNA
Polymorphic catecholergic ventricular tachycardia
18 Citations (Scopus)

Major Proteomic Changes Associated with Amyloid-Induced Biofilm Formation in Pseudomonas aeruginosa PAO1

Herbst, F-A., Søndergaard, M. T., Kjeldal, H., Stensballe, A., Nielsen, P. H. & Dueholm, M. S., 2015, In : Journal of Proteome Research. 14, 1, p. 72-81 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Biofilms
Amyloid
Proteomics
Pseudomonas aeruginosa
Pseudomonas
2014
11 Citations (Scopus)

Heparin binding mechanism of the insulin-like growth factor (IGF) 2 / IGF binding protein 2 complex

Lund, J., Sondergaard, M. T., Conover, C. A. & Overgaard, M. T., 6 Mar 2014, In : Journal of Molecular Endocrinology. 52, 3, p. 345-355

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Insulin-Like Growth Factor Binding Protein 2
Somatomedins
Heparin
Insulin-Like Growth Factor Binding Proteins
A73025
2013
36 Citations (Scopus)

Calmodulin in a Heartbeat

Sorensen, A. B., Søndergaard, M. T. & Overgaard, M. T., 13 May 2013, In : F E B S Journal. 280, 21, p. 5511-5532

Research output: Contribution to journalJournal articleResearchpeer-review

68 Citations (Scopus)

Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation

Dueholm, M. S., Søndergaard, M. T., Nilsson, M., Christiansen, G., Stensballe, A., Overgaard, M. T., Givskov, M. C., Tolker-Nielsen, T., Otzen, D. E. & Nielsen, P. H., 18 Mar 2013, In : MicrobiologyOpen. 2, 3, p. 365-382

Research output: Contribution to journalJournal articleResearchpeer-review

2012
196 Citations (Scopus)

Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death

Nyegaard, M., Overgaard, M. T., Sondergaard, M. T., Vranas, M., Behr, E. R., Hildebrandt, L. L., Lund, J., Hedley, P. L., Camm, A. J., Wettrell, G., Fosdal, I., Christiansen, M. & Borglum, A. D., 2012, In : American Journal of Human Genetics. 91, 4, p. 703-712 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Sudden Cardiac Death
Calmodulin
Ventricular Tachycardia
Mutation
Cardiac Arrhythmias