Projects per year
Personal profile
Research profile
My main research focus is gene therapy at the blood-brain barrier to enable transport/secretion of therapeutic proteins into the brain parenchyma as a strategy for treatning neurodegenerative diseases like Niemann Pick Disease or Alzheimers Disease
Teaching profile
My main teaching obligations involve:
- Casefacilitation on 3rd og 4th sem Medis/Medicin Bachelor
- Semester Coordination of 4th sem Medis/Medicin Bachelor
- Module coordinator of 4th sem Medis/Medicin Bachelor projektmodul
- Projectsupervisor for 4th and 6th sem Medis/Medicin Bachelor students
- Projectsupervisor for 1st to 4th sem Medis Master students
- Module coordinator on the 1st sem Medis Master module Molecular Pathogenesis
- Lecturer on 1st , 4th and 5th sem Medis/Medicin Bachelor
- Lecturer on 1st and 2th sem Medis Master
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Assistant Professor course, Assistant Professor Course, Assistant professor - Learning Report
Award Date: 28 Feb 2019
Medicine with Industrial Specialisation, Master Degree, GENE DELIVERY OF THERAPEUTIC POLYPEPTIDES INTO BRAIN CAPILLARY ENDOTHELIAL CELLS FOR PROTEIN SECRETION, Department of Health Science and Technology
1 Sept 2009 → 15 Jun 2011
Award Date: 22 Jul 2011
Medicine with Industrial Specialisering, Bachelor Degree, Department of Health Science and Technology
1 Sept 2007 → 15 Jun 2009
Award Date: 24 Jul 2009
Molecular Biology, Bachelor degree, X-kromosome Inactivation and Imprinting, Aarhus University
1 Sept 2004 → 29 Jun 2007
Award Date: 29 Jun 2007
Keywords
- Biomedicine
- Gene Therapy
- Blood-Brain barrier (BBB)
- In Vitro BBB Models
- Niemann Pick Disease Type C2
- Iron transport across the BBB
- Drug Delivery to the Brain
- Medicine
Fingerprint
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Collaborations from the last five years
Dive into details by clicking on the dots.
Projects
- 1 Finished
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Epigenetisk regulering af ferroportin i den neurovaskulære enhed
Helgudottir, S. S. (PI), Lichota, J. (Supervisor), Routhe, L. J. (CoI), Moos, T. (Supervisor), Jønsson, K. (CoI), Larsen, A. B. (PI) & Pedersen, I. S. (CoI)
01/12/2017 → 01/11/2019
Project: Research
Research output
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The Npc2Gt(LST105)BygNya mouse signifies pathological changes comparable to human Niemann-Pick type C2 disease
Rasmussen, C. L. M., Thomsen, L. B., Heegaard, C. W., Moos, T. & Burkhart, A., Sept 2023, In: Molecular and Cellular Neuroscience. 126, 103880.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)2 Downloads (Pure) -
Activation of glial cells induces proinflammatory properties in brain capillary endothelial cells in vitro
Burkhart, A., Helgudóttir, S. S., Mahamed, Y. A., Fruergaard, M. B., Holm-Jacobsen, J. N., Haraldsdóttir, H., Dahl, S. E., Pretzmann, F., Routhe, L. G., Lambertsen, K., Moos, T. & Thomsen, M. S., 4 Nov 2024, In: Scientific Reports. 14, 1, 26580.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Downloads (Pure) -
A novel strategy for delivering Niemann-Pick type C2 proteins across the blood-brain barrier using the brain endothelial-specific AAV-BR1 virus
Rasmussen, C. L. M., Hede, E., Routhe, L. J., Körbelin, J., Helgudottir, S. S., Thomsen, L. B., Schwaninger, M., Burkhart, A. & Moos, T., Jan 2023, In: Journal of Neurochemistry. 164, 1, p. 6-28 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile6 Citations (Scopus)53 Downloads (Pure) -
The blood-brain barrier studied in vitro across species
Thomsen, M. S., Humle, N., Hede, E., Moos, T., Burkhart, A. & Thomsen, L. B., 12 Mar 2021, In: PLOS ONE. 16, 3, e0236770.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile41 Citations (Scopus)94 Downloads (Pure) -
Gene therapy to the blood-brain barrier with resulting protein secretion as a strategy for treatment of Niemann Picks type C2 disease
Hede, E., Christiansen, C. B., Heegaard, C. W., Moos, T. & Burkhart, A., Feb 2021, In: Journal of Neurochemistry. 156, 3, p. 290-308 19 p., e14982.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile9 Citations (Scopus)238 Downloads (Pure)