Photo of Sakari Kauppinen

Sakari Kauppinen

  • Frederikskaj 10B, C, FK10B-218

    2450 København SV

    Denmark

20102019
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Research Output 2010 2019

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Journal article
2019

Intragenic antagonistic roles of protein and circRNA in tumorigenesis

Guarnerio, J., Zhang, Y., Cheloni, G., Panella, R., Mae Katon, J., Simpson, M., Matsumoto, A., Papa, A., Loretelli, C., Petri, A., Kauppinen, S., Garbutt, C., Petur Nielsen, G., Deshpande, V., Castillo-Martin, M., Cordon-Cardo, C., Dimitrios, S., Clohessy, J. G., Batish, M. & Pandolfi, P. P., 1 Aug 2019, In : Cell Research. 29, 8, p. 628-640 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Carcinogenesis
Neoplasms
Proteins
Angiogenesis Inducing Agents
Transcription Factors
2018
1 Citation (Scopus)

Development of Locked Nucleic Acid Antisense Oligonucleotides Targeting Ebola Viral Proteins and Host Factor Niemann-Pick C1

Chery, J., Petri, A., Wagschal, A., Lim, S-Y., Cunningham, J., Vasudevan, S., Kauppinen, S. & Näär, A. M., 1 Oct 2018, In : Nucleic Acid Therapeutics. 28, 5, p. 273-284 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Antisense Oligonucleotides
Viral Proteins
Viruses
Ebolavirus
Ebola Hemorrhagic Fever
1 Citation (Scopus)

Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche

Tsukamoto, S., Løvendorf, M. B., Park, J., Salem, K. Z., Reagan, M. R., Manier, S., Zavidij, O., Rahmat, M., Huynh, D., Takagi, S., Kawano, Y., Kokubun, K., Thrue, C. A., Nagano, K., Petri, A., Roccaro, A. M., Capelletti, M., Baron, R., Kauppinen, S. & Ghobrial, I. M., 2018, In : Leukemia. 32, 8, p. 1739-1750 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Multiple Myeloma
MicroRNAs
Osteogenesis
Bone Marrow
Bone Diseases
2016
19 Citations (Scopus)

Identification of antisense long noncoding RNAs that function as SINEUPs in human cells

Schein, A., Zucchelli, S., Kauppinen, S., Gustincich, S. & Carninci, P., 2016, In : Scientific Reports. 6, 8 p., 33605.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Long Noncoding RNA
Protein Phosphatase 1
Protein Biosynthesis
Ubiquitin Thiolesterase
Short Interspersed Nucleotide Elements
2015
24 Citations (Scopus)

Long Noncoding RNA Expression during Human B-Cell Development

Petri, A., Dybkær, K., Bøgsted, M., Thrue, C. A., Hagedorn, P. H., Schmitz, A., Bødker, J. S., Johnsen, H. E. & Kauppinen, S., 2015, In : PLOS ONE. 10, 9, 19 p., e0138236.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Long Noncoding RNA
B-lymphocytes
B-Lymphocytes
Cells
antisense RNA
2 Citations (Scopus)

Transcriptome dynamics of the microRNA inhibition response

Wen, J., Leucci, E., Vendramin, R., Kauppinen, S., Lund, A. H., Krogh, A. & Parker, B. J., 2015, In : Nucleic Acids Research. 43, 13, p. 6207-6221 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
MicroRNAs
Transcriptome
Post Transcriptional RNA Processing
RNA-Binding Proteins
Gene Regulatory Networks
2014
31 Citations (Scopus)

Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-Convergence on axonal guidance

Kaalund, S. S., Venø, M. T., Bak, M., Møller, R. S., Laursen, H., Madsen, F., Broholm, H., Quistorff, B., Uldall, P., Tommerup, N., Kauppinen, S., Sabers, A., Fluiter, K., Møller, L. B., Nossent, A. Y., Silahtaroglu, A., Kjems, J., Aronica, E. & Tümer, Z., 19 Nov 2014, In : Epilepsia. 55, 12, p. 2017-2027 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Temporal Lobe Epilepsy
Sclerosis
MicroRNAs
Hippocampus
Sus scrofa
310 Citations (Scopus)

Development of microRNA therapeutics is coming of age

van Rooij, E. & Kauppinen, S., 2014, In : E M B O Molecular Medicine (Online). 6, 7, p. 851-864 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
MicroRNAs
Biological Phenomena
Virus Diseases
Therapeutics
Hepacivirus
44 Citations (Scopus)

Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy

Bernardo, B. C., Gao, X-M., Tham, Y. K., Kiriazis, H., Winbanks, C. E., Ooi, J. Y. Y., Boey, E. J. H., Obad, S., Kauppinen, S., Gregorevic, P., Du, X-J., Lin, R. C. Y. & McMullen, J. R., 2014, In : P L o S One. 9, 2, e90337.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Hypertrophic Cardiomyopathy
cardiomyopathy
Pathology
mice
therapeutics
2013
138 Citations (Scopus)

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

Leucci, E., Patella, F., Waage, J., Holmstrøm, K., Lindow, M., Porse, B., Kauppinen, S. & Lund, A. H., 29 Aug 2013, In : Scientific Reports. 3, 6 p., 2535.

Research output: Contribution to journalJournal articleResearchpeer-review

73 Citations (Scopus)

Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR

Rottiers, V., Obad, S., Petri, A., McGarrah, R., Lindholm, M. W., Black, J. C., Sinha, S., Goody, R. J., Lawrence, M. S., Delemos, A. S., Hansen, H. F., Whittaker, S., Henry, S., Brookes, R., Najafi-Shoushtari, S. H., Chung, R. T., Whetstine, J. R., Gerszten, R. E., Kauppinen, S. & Näär, A. M., 20 Nov 2013, In : Science Translational Medicine. 5, 212, p. 212ra162

Research output: Contribution to journalJournal articleResearchpeer-review

MicroRNAs
Primates
Seeds
Pharmacology
Primate Diseases
77 Citations (Scopus)

Silencing of the miR-17~92 Cluster Family Inhibits Medulloblastoma Progression

Murphy, B. L., Obad, S., Bihannic, L., Ayrault, O., Zindy, F., Kauppinen, S. & Roussel, M. F., 1 Dec 2013, In : Cancer Research. 73, 23, p. 7068-78 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Medulloblastoma
Hedgehogs
Seeds
MicroRNAs
Neoplasms
2012
164 Citations (Scopus)

Discovering the first microRNA-targeted drug

Lindow, M. & Kauppinen, S., 2012, In : Journal of Cell Biology. 199, 3, p. 407-412

Research output: Contribution to journalJournal articleResearchpeer-review

61 Citations (Scopus)

Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo

Leucci, E., Zriwil, A., Gregersen, L. H., Jensen, K. T., Obad, S., Bellan, C., Leoncini, L., Kauppinen, S. & Lund, A. H., 6 Dec 2012, In : Oncogene. 31, 49, p. 5081-5089 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Hodgkin Disease
Neoplasms
Regulator Genes
Tumor Cell Line
MicroRNAs
97 Citations (Scopus)

LNA-mediated anti-miR-155 silencing in low-grade B-cell lymphomas

Zhang, Y., Roccaro, A. M., Rombaoa, C., Flores, L. M., Obad, S., Fernandes, S. M., Sacco, A., Liu, Y., Ngo, H., Quang, P., Azab, A. K., Azab, F., Maiso, P., Reagan, M. R., Brown, J. R., Thai, T. H., Kauppinen, S. & Ghobrial, I. M., 23 Aug 2012, In : Blood. 120, 8, p. 1678-1686 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Waldenstrom Macroglobulinemia
B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Tumors
Cells
100 Citations (Scopus)

MicroRNA Profiling Identifies MicroRNA-155 as an Adverse Mediator of Cardiac Injury and Dysfunction during Acute Viral MyoCarditis

Corsten, M. F., Papageorgiou, A., Verhesen, W., Carai, P., Lindow, M., Obad, S., Summer, G., Coort, S. L. M., Hazebroek, M., Van Leeuwen, R., Gijbels, M. J. J., Wijnands, E., Biessen, E. A. L., De Winther, M. P. J., Stassen, F. R. M., Carmeliet, P., Kauppinen, S., Schroen, B. & Heymans, S., 3 Aug 2012, In : Circulation Research. 111, 4, p. 415-425 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Myocarditis
MicroRNAs
Wounds and Injuries
Virus Diseases
Macrophages
83 Citations (Scopus)

miR-21 is up-regulated in psoriasis and suppresses T cell apoptosis

Meisgen, F., Xu, N., Wei, T., Janson, P. C., Obad, S., Broom, O., Nagy, N., Kauppinen, S., Kemény, L., Ståhle, M., Pivarcsi, A. & Sonkoly, E., 1 Apr 2012, In : Experimental Dermatology Online. 21, 4, p. 312-314 3 p.

Research output: Contribution to journalJournal articleResearchpeer-review

T-cells
MicroRNAs
Psoriasis
Apoptosis
T-Lymphocytes
89 Citations (Scopus)

Regulation of acute graft-versus-host disease by microRNA-155

Ranganathan, P., Heaphy, C. E. A., Costinean, S., Stauffer, N., Na, C., Hamadani, M., Santhanam, R., Mao, C., Taylor, P. A., Sandhu, S., He, G., Shana'ah, A., Nuovo, G. J., Lagana, A., Cascione, L., Obad, S., Broom, O., Kauppinen, S., Byrd, J. C., Caligiuri, M. & 7 others, Perrotti, D., Hadley, G. A., Marcucci, G., Devine, S. M., Blazar, B. R., Croce, C. M. & Garzon, R., 17 May 2012, In : Blood. 119, 20, p. 4786-4797 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Graft vs Host Disease
MicroRNAs
Grafts
Transplants
T-cells
222 Citations (Scopus)

Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function

Bernardo, B. C., Gao, X., Winbanks, C. E., Boey, E. J. H., Tham, Y., Kiriazis, H., Gregorevic, P., Obad, S., Kauppinen, S., Du, X., Lin, R. C. Y. & McMullen, J. R., 23 Oct 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 43, p. 17615-17620 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

MicroRNAs
Myocardial Infarction
Seeds
Therapeutics
Constriction
79 Citations (Scopus)

The therapeutic potential of MicroRNAs in cancer

Thorsen, S., Obad, S., Jensen, N. F., Stenvang, J. & Kauppinen, S., 1 May 2012, In : Cancer Journal. 18, 3, p. 275-284 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

MicroRNAs
Neoplasms
Therapeutics
Biological Phenomena
Antisense Oligonucleotides
2011
27 Citations (Scopus)

Cell-specific detection of microRNA expression during cardiomyogenesis by combined in situ hybridization and immunohistochemistry

Schneider, M., Andersen, D. C., Silahtaroglu, A., Lyngbæk, S., Kauppinen, S., Hansen, J. L. & Sheikh, S. P., Aug 2011, In : Journal of Molecular Histology (Print Edition). 42, 4, p. 289-299 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

MicroRNAs
In Situ Hybridization
Immunohistochemistry
Embryoid Bodies
Cardiac Myocytes
278 Citations (Scopus)

MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo

Eskildsen, T., Taipaleenmäki, H., Stenvang, J., Abdallah, B., Ditzel, N., Nossent, A. Y., Bak, M., Kauppinen, S. & Kassem, M., Apr 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 15, p. 6139-6144 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

MicroRNAs
Mesenchymal Stromal Cells
Osteoblasts
Osteogenesis
Focal Adhesion Protein-Tyrosine Kinases
26 Citations (Scopus)

mRNA expression profiling reveals conserved and non-conserved miR-140 targets.

Nicolas, F. E., Pais, H., Schwach, F., Lindow, M., Kauppinen, S., Moulton, V. & Dalmay, T., 2011, In : RNA Biology. 8, 4, p. 607-615 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

MicroRNAs
Messenger RNA
Chickens
Untranslated RNA
Chondrocytes
116 Citations (Scopus)

Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice

Garchow, B. G., Encinas, O. B., Leung, Y. T., Tsao, P. Y., Eisenberg, R. A., Caricchio, R., Obad, S., Petri, A., Kauppinen, S. & Kiriakidou, M., 2011, In : E M B O Molecular Medicine. 3, 10, p. 605-616

Research output: Contribution to journalJournal articleResearchpeer-review

445 Citations (Scopus)

Silencing of microRNA families by seed-targeting tiny LNAs

Obad, S., Dos Santos, C. O., Petri, A., Heidenblad, M., Broom, O., Ruse, C., Fu, C., Lindow, M., Stenvang, J., Straarup, E. M., Hansen, H. F., Koch, T., Pappin, D., Hannon, G. J. & Kauppinen, S., Apr 2011, In : Nature Genetics. 43, 4, p. 371-378

Research output: Contribution to journalJournal articleResearchpeer-review

MicroRNAs
Seeds
Genomics
Oligonucleotides
Proteomics
144 Citations (Scopus)

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

Castoldi, M., Spasic, M. V., Altamura, S., Elmén, J., Lindow, M., Kiss, J., Stolte, J., Sparla, R., D'Alessandro, L. A., Klingmüller, U., Fleming, R. E., Longerich, T., Gröne, H. J., Benes, V., Kauppinen, S., Hentze, M. W. & Muckenthaler, M. U., Apr 2011, In : Journal of Clinical Investigation. 121, 4, p. 1386-1396 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

MicroRNAs
Homeostasis
Iron
Liver
Hepcidins
2010
80 Citations (Scopus)

Fluorescence-Based Codetection with Protein Markers Reveals Distinct Cellular Compartments for Altered MicroRNA Expression in Solid Tumors

Sempere, L. F., Preis, M., Yezefski, T., Ouyang, H., Suriawinata, A. A., Silahtaroglu, A., Conejo-Garcia, J. R., Kauppinen, S., Wells, W. & Korc, M., 2010, In : Clinical Cancer Research. 16, 16, p. 4246-4255 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

303 Citations (Scopus)

MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors

Liu, X., Sempere, L. F., Ouyang, H., Memoli, V. A., Andrew, A. S., Luo, Y., Demidenko, E., Korc, M., Shi, W., Preis, M., Dragnev, K. H., Li, H., Direnzo, J., Bak, M., Freemantle, S. J., Kauppinen, S. & Dmitrovsky, E., 1 Apr 2010, In : Journal of Clinical Investigation. 120, 4, p. 1298-309 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

MicroRNAs
Lung Neoplasms
Neoplasms
Lung
Messenger RNA

MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4

Sonkoly, E., Janson, P., Majuri, M-L., Savinko, T., Fyhrquist, N., Eidsmo, L., Xu, N., Meisgen, F., Wei, T., Bradley, M., Stenvang, J., Kauppinen, S., Alenius, H., Lauerma, A., Homey, B., Winqvist, O., Ståhle, M. & Pivarcsi, A., 2010, In : Journal of Allergy and Clinical Immunology. 126, 3, p. 581-589.e20 29 p.

Research output: Contribution to journalJournal articleResearchpeer-review

CTLA-4 Antigen
Small Untranslated RNA
Atopic Dermatitis
MicroRNAs
Skin Diseases
12 Citations (Scopus)

miRMaid: a unified programming interface for microRNA data resources

Jacobsen, A., Krogh, A., Kauppinen, S. & Lindow, M., 1 Jan 2010, In : B M C Bioinformatics. 11, 29

Research output: Contribution to journalJournal articleResearchpeer-review

MicroRNA
RNA
MicroRNAs
Gene expression
Animals
263 Citations (Scopus)

Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice

Patrick, D. M., Montgomery, R. L., Qi, X., Obad, S., Kauppinen, S., Hill, J. A., van Rooij, E. & Olson, E. N., 1 Nov 2010, In : Journal of Clinical Investigation. 120, 11, p. 3912-3916 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

MicroRNAs
Cardiomegaly
Fibrosis
RNA Stability
Protein Biosynthesis
1297 Citations (Scopus)

Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

Lanford, R. E., Hildebrandt-Eriksen, E. S., Petri, A., Persson, R., Lindow, M., Munk, M. E., Kauppinen, S. & Ørum, H., 8 Jan 2010, In : Science. 327, 5962, p. 198-201 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Chronic Hepatitis C
Virus Diseases
MicroRNAs
Hepacivirus
Primates