Sakari Kauppinen

Research output

Research output per year 2010 2010 2011 2012 2013 2018 2022 2023 2023

• 48 Journal article
• 6 Conference abstract in journal
• 5 Review article
• 5 Patent
• 4 More
  • 2 Book chapter
  • 2 Comment/debate

Research output per year

Research output per year

Search results

• Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-Convergence on axonal guidance

  Kaalund, S. S., Venø, M. T., Bak, M., Møller, R. S., Laursen, H., Madsen, F., Broholm, H., Quistorff, B., Uldall, P., Tommerup, N., Kauppinen, S., Sabers, A., Fluiter, K., Møller, L. B., Nossent, A. Y., Silahtaroglu, A., Kjems, J., Aronica, E. & Tümer, Z., 19 Nov 2014, In: Epilepsia. 55, 12, p. 2017-2027 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MicroRNA 100%
  • Hippocampal Sclerosis 100%
  • Mesial Temporal Lobe Epilepsy 100%
  • Hippocampus 62%
  • Neuron 25%
  63 Citations (Scopus)

• A MicroRNA Linking Human Positive Selection and Metabolic Disorders

  Wang, L., Sinnott-Armstrong, N., Wagschal, A., Wark, A. R., Camporez, J. P., Perry, R. J., Ji, F., Sohn, Y., Oh, J., Wu, S., Chery, J., Moud, B. N., Saadat, A., Dankel, S. N., Mellgren, G., Tallapragada, D. S. P., Strobel, S. M., Lee, M. J., Tewhey, R., Sabeti, P. C., & 12 othersSchaefer, A., Petri, A., Kauppinen, S., Chung, R. T., Soukas, A., Avruch, J., Fried, S. K., Hauner, H., Sadreyev, R. I., Shulman, G. I., Claussnitzer, M. & Näär, A. M., 29 Oct 2020, In: Cell. 183, 3, p. 684-701.e14

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MicroRNA 100%
  • Metabolic Disorder 100%
  • Antisense 50%
  • Lactase 33%
  • Glucose 33%
  39 Citations (Scopus)

• An intranasal ASO therapeutic targeting SARS-CoV-2

  Zhu, C., Lee, J. Y., Woo, J. Z., Xu, L., Nguyenla, X., Yamashiro, L. H., Ji, F., Biering, S. B., Van Dis, E., Gonzalez, F., Fox, D., Wehri, E., Rustagi, A., Pinsky, B. A., Schaletzky, J., Blish, C. A., Chiu, C., Harris, E., Sadreyev, R. I., Stanley, S., & 3 othersKauppinen, S., Rouskin, S. & Näär, A. M., 3 Aug 2022, In: Nature Communications. 13, 1, p. 4503 4503.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • SARS Coronavirus 100%
  • Locked Nucleic Acid 85%
  • Antisense Oligonucleotide 85%
  • COVID-19 57%
  25 Citations (Scopus)

  50 Downloads (Pure)

• Antisense-oligonucleotide-mediated perturbation of long non-coding RNA reveals functional features in stem cells and across cell types

  Yip, C. W., Hon, C-C., Yasuzawa, K., Sivaraman, D. M., Ramilowski, J. A., Shibayama, Y., Agrawal, S., Prabhu, A. V., Parr, C., Severin, J., Lan, Y. J., Dostie, J., Petri, A., Nishiyori-Sueki, H., Tagami, M., Itoh, M., López-Redondo, F., Kouno, T., Chang, J-C., Luginbühl, J., & 14 othersKato, M., Murata, M., Yip, W. H., Shu, X., Abugessaisa, I., Hasegawa, A., Suzuki, H., Kauppinen, S., Yagi, K., Okazaki, Y., Kasukawa, T., de Hoon, M., Carninci, P. & Shin, J. W., 27 Dec 2022, In: Cell reports. 41, 13, 111893.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Stem Cell 100%
  • Oligonucleotide 100%
  • Long Non-Coding RNA 100%
  • Antisense 100%
  • Cell Growth 28%
  6 Citations (Scopus)

  81 Downloads (Pure)

• Assessment of immunostimulatory responses to the antimiR-22 oligonucleotide compound RES-010 in human peripheral blood mononuclear cells

  Panella, R., Zanderigo, F., Morandini, F., Federico, D., Vicentini, E., Andreetta, F., Toniolo, A. & Kauppinen, S., 23 Mar 2023, In: Frontiers in Pharmacology. 14, 1125654.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Peripheral Blood Mononuclear Cell 100%
  • T Cell Activation 25%
  • Antisense 25%
  • Tumor Necrosis Factor 25%
  • Interleukin-6 25%
  19 Downloads (Pure)

• Cell-specific detection of microRNA expression during cardiomyogenesis by combined in situ hybridization and immunohistochemistry

  Schneider, M., Andersen, D. C., Silahtaroglu, A., Lyngbæk, S., Kauppinen, S., Hansen, J. L. & Sheikh, S. P., Aug 2011, In: Journal of Molecular Histology (Print Edition). 42, 4, p. 289-299 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MicroRNA 100%
  • Fluorescence 7%
  • Myosin 7%
  • Embryogenesis 7%
  • Stromal Cell 7%
  32 Citations (Scopus)

• Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases

  Holm, A., Hansen, S. N., Klitgaard, H. & Kauppinen, S., 2022, In: RNA Biology. 19, 1, p. 594-608 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Nervous System Disorder 100%
  • Neuromuscular Disorder 100%
  • Small Hairpin RNA 85%
  • Central Nervous System 57%
  • Amyotrophic Lateral Sclerosis 42%
  20 Citations (Scopus)

  156 Downloads (Pure)

• Clinical and functional significance of circular RNAs in cytogenetically normal AML

  Papaioannou, D., Volinia, S., Nicolet, D., Świerniak, M., Petri, A., Mrózek, K., Bill, M., Pepe, F., Walker, C. J., Walker, A. E., Carroll, A. J., Kohlschmidt, J., Eisfeld, A-K., Powell, B. L., Uy, G. L., Kolitz, J. E., Wang, E. S., Kauppinen, S., Dorrance, A., Stone, R. M., & 3 othersByrd, J. C., Bloomfield, C. D. & Garzon, R., 28 Jan 2020, In: Blood advances. 4, 2, p. 239-251 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Circular RNA 100%
  • Ribonuclease 25%
  • Messenger RNA 25%
  • Exon 25%
  • Gene Expression Profiling 25%
  27 Citations (Scopus)

  71 Downloads (Pure)

• Development of Locked Nucleic Acid Antisense Oligonucleotides Targeting Ebola Viral Proteins and Host Factor Niemann-Pick C1

  Chery, J., Petri, A., Wagschal, A., Lim, S-Y., Cunningham, J., Vasudevan, S., Kauppinen, S. & Näär, A. M., 1 Oct 2018, In: Nucleic Acid Therapeutics. 28, 5, p. 273-284 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  • Locked Nucleic Acid 100%
  • Antisense Oligonucleotide 100%
  • Oligonucleotide Targeting 100%
  • Antisense 100%
  • Viral Protein 100%
  18 Citations (Scopus)

• Development of microRNA therapeutics is coming of age

  van Rooij, E. & Kauppinen, S., 2014, In: E M B O Molecular Medicine (Online). 6, 7, p. 851-864 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  • Diseases 100%
  510 Citations (Scopus)

• Discovering the first microRNA-targeted drug

  Lindow, M. & Kauppinen, S., 2012, In: Journal of Cell Biology. 199, 3, p. 407-412

  Research output: Contribution to journal › Journal article › Research › peer-review
  257 Citations (Scopus)

• FibroDB: Expression Analysis of Protein-Coding and Long Non-Coding RNA Genes in Fibrosis

  Ilieva, M. S., Miller, H. E., Agarwal, A., Paulus, G. K., Madsen, J. H., Bishop, A. J. R., Kauppinen, S. & Uchida, S., 28 Jan 2022, In: Non-coding RNA. 8, 1, 13.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Long Non-Coding RNA 100%
  • Expression Analysis 100%
  • Protein Characterization 100%
  • Gene 100%
  • Long Noncoding RNA 75%
  10 Citations (Scopus)

  67 Downloads (Pure)

• Fluorescence-Based Codetection with Protein Markers Reveals Distinct Cellular Compartments for Altered MicroRNA Expression in Solid Tumors

  Sempere, L. F., Preis, M., Yezefski, T., Ouyang, H., Suriawinata, A. A., Silahtaroglu, A., Conejo-Garcia, J. R., Kauppinen, S., Wells, W. & Korc, M., 2010, In: Clinical Cancer Research. 16, 16, p. 4246-4255 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  95 Citations (Scopus)

• Functional annotation of human long noncoding RNAs via molecular phenotyping

  Ramilowski, J. A., Yip, C. W., Agrawal, S., Chang, J-C., Ciani, Y., Kulakovskiy, I. V., Mendez, M., Ooi, J. L. C., Ouyang, J. F., Parkinson, N., Petri, A., Roos, L., Severin, J., Yasuzawa, K., Abugessaisa, I., Akalin, A., Antonov, I. V., Arner, E., Bonetti, A., Bono, H., & 96 othersBorsari, B., Brombacher, F., Cameron, C. JF., Cannistraci, C. V., Cardenas, R., Cardon, M., Chang, H., Dostie, J., Ducoli, L., Favorov, A., Fort, A., Garrido, D., Gil, N., Gimenez, J., Guler, R., Handoko, L., Harshbarger, J., Hasegawa, A., Hasegawa, Y., Hashimoto, K., Hayatsu, N., Heutink, P., Hirose, T., Imada, E. L., Itoh, M., Kaczkowski, B., Kanhere, A., Kawabata, E., Kawaji, H., Kawashima, T., Kelly, S. T., Kojima, M., Kondo, N., Koseki, H., Kouno, T., Kratz, A., Kurowska-Stolarska, M., Kwon, A. T. J., Leek, J., Lennartsson, A., Lizio, M., López-Redondo, F., Luginbühl, J., Maeda, S., Makeev, V. J., Marchionni, L., Medvedeva, Y. A., Minoda, A., Müller, F., Muñoz-Aguirre, M., Murata, M., Nishiyori, H., Nitta, K. R., Noguchi, S., Noro, Y., Nurtdinov, R., Okazaki, Y., Orlando, V., Paquette, D., Parr, C. J. C., Rackham, O. J. L., Rizzu, P., Sánchez Martinez, D. F., Sandelin, A., Sanjana, P., Semple, C. A. M., Shibayama, Y., Sivaraman, D. M., Suzuki, T., Szumowski, S. C., Tagami, M., Taylor, M. S., Terao, C., Thodberg, M., Thongjuea, S., Tripathi, V., Ulitsky, I., Verardo, R., Vorontsov, I. E., Yamamoto, C., Young, R. S., Baillie, J. K., Forrest, A. R. R., Guigó, R., Hoffman, M. M., Hon, C. C., Kasukawa, T., Kauppinen, S., Kere, J., Lenhard, B., Schneider, C., Suzuki, H., Yagi, K., de Hoon, M. J. L., Shin, J. W. & Carninci, P., Jul 2020, In: Genome Research. 30, 7, p. 1060-1072 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Long Noncoding RNA 100%
  • Antisense 25%
  • Oligonucleotide 20%
  • Gene 20%
  89 Citations (Scopus)

  85 Downloads (Pure)

• Identification of antisense long noncoding RNAs that function as SINEUPs in human cells

  Schein, A., Zucchelli, S., Kauppinen, S., Gustincich, S. & Carninci, P., 2016, In: Scientific Reports. 6, 8 p., 33605.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  • Long Noncoding RNA 100%
  • Antisense 100%
  • Human Cell 100%
  • Protein Phosphatase 1 42%
  • Translation (Protein Synthesis) 28%
  52 Citations (Scopus)

• Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche

  Tsukamoto, S., Løvendorf, M. B., Park, J., Salem, K. Z., Reagan, M. R., Manier, S., Zavidij, O., Rahmat, M., Huynh, D., Takagi, S., Kawano, Y., Kokubun, K., Thrue, C. A., Nagano, K., Petri, A., Roccaro, A. M., Capelletti, M., Baron, R., Kauppinen, S. & Ghobrial, I. M., 2018, In: Leukemia. 32, 8, p. 1739-1750 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • microRNA 100%
  • Multiple Myeloma 100%
  • Bone Marrow 100%
  • Mesenchymal Stem Cell 66%
  • Myeloma Bone Disease 50%
  33 Citations (Scopus)

• Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo

  Leucci, E., Zriwil, A., Gregersen, L. H., Jensen, K. T., Obad, S., Bellan, C., Leoncini, L., Kauppinen, S. & Lund, A. H., 6 Dec 2012, In: Oncogene. 31, 49, p. 5081-5089 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Xenograft 100%
  • Breast 100%
  • Inflammatory Cell 100%
  • MicroRNA 100%
  • Protein 100%
  79 Citations (Scopus)

• Intragenic antagonistic roles of protein and circRNA in tumorigenesis

  Guarnerio, J., Zhang, Y., Cheloni, G., Panella, R., Mae Katon, J., Simpson, M., Matsumoto, A., Papa, A., Loretelli, C., Petri, A., Kauppinen, S., Garbutt, C., Petur Nielsen, G., Deshpande, V., Castillo-Martin, M., Cordon-Cardo, C., Dimitrios, S., Clohessy, J. G., Batish, M. & Pandolfi, P. P., 1 Aug 2019, In: Cell Research. 29, 8, p. 628-640 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  • Protein 100%
  • RNA 100%
  • Transcription Factor 50%
  • Tumor Progression 50%
  • Genetics 50%
  106 Citations (Scopus)

• Knockdown of Circular RNAs Using LNA-Modified Antisense Oligonucleotides

  Løvendorf, M. B., Holm, A., Petri, A., Thrue, C. A., Uchida, S., Venø, M. T. & Kauppinen, S., 1 Feb 2023, In: Nucleic Acid Therapeutics. 33, 1, p. 45-57 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Oligonucleotide 100%
  • Antisense 100%
  • Circular RNA 100%
  • Protein 22%
  • Gene 22%
  2 Citations (Scopus)

• Knockdown of the long noncoding RNA PURPL induces apoptosis and sensitizes liver cancer cells to doxorubicin

  Berhane, T., Holm, A., Karstensen, K. T., Petri, A., Ilieva, M. S., Krarup, H., Vyberg, M., Løvendorf, M. B. & Kauppinen, S., 14 Nov 2022, In: Scientific Reports. 12, 1, 19502.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Cancer Cell 100%
  • Programmed Cell Death 100%
  • Doxorubicin 100%
  • Hepatocellular Carcinoma 100%
  • Protein P53 100%
  4 Citations (Scopus)

  36 Downloads (Pure)

• LNA-mediated anti-miR-155 silencing in low-grade B-cell lymphomas

  Zhang, Y., Roccaro, A. M., Rombaoa, C., Flores, L. M., Obad, S., Fernandes, S. M., Sacco, A., Liu, Y., Ngo, H., Quang, P., Azab, A. K., Azab, F., Maiso, P., Reagan, M. R., Brown, J. R., Thai, T. H., Kauppinen, S. & Ghobrial, I. M., 23 Aug 2012, In: Blood. 120, 8, p. 1678-1686 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • B-Cell Lymphoma 100%
  • microRNA 155 100%
  • B Cell 100%
  • Macroglobulinemia 100%
  • Waldenström's Macroglobulinemia 58%
  136 Citations (Scopus)

• Long Noncoding RNA Expression during Human B-Cell Development

  Petri, A., Dybkær, K., Bøgsted, M., Thrue, C. A., Hagedorn, P. H., Schmitz, A., Bødker, J. S., Johnsen, H. E. & Kauppinen, S., 2015, In: PLOS ONE. 10, 9, 19 p., e0138236.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  • B Cell Development 100%
  • Long Noncoding RNA 100%
  • B Cell 75%
  • Antisense 50%
  • Probe 50%
  72 Citations (Scopus)

• Long Non-Coding RNAs in Diffuse Large B-Cell Lymphoma

  Karstensen, K. T., Schein, A., Petri, A., Bøgsted, M., Dybkær, K., Uchida, S. & Kauppinen, S., Jan 2021, In: Non-coding RNA. 7, 1, 13 p., 1.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Diffuse Large B-Cell Lymphoma 100%
  • Long Untranslated RNA 100%
  • B Cell 100%
  • Patient 28%
  • Protein 14%
  7 Citations (Scopus)

  68 Downloads (Pure)

• MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo

  Eskildsen, T., Taipaleenmäki, H., Stenvang, J., Abdallah, B., Ditzel, N., Nossent, A. Y., Bak, M., Kauppinen, S. & Kassem, M., Apr 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 15, p. 6139-6144 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MicroRNA 100%
  • Stem Cell 100%
  • Mesenchymal Stem Cell 100%
  • Focal Adhesion 40%
  • Lineages 20%
  418 Citations (Scopus)

• MicroRNA-22 Is a Key Regulator of Lipid and Metabolic Homeostasis

  Panella, R., Petri, A., Desai, B. N., Fagoonee, S., Cotton, C. A., Nguyen, P. K., Lundin, E. M., Wagshal, A., Wang, D-Z., Näär, A. M., Vlachos, I. S., Maratos-Flier, E., Altruda, F., Kauppinen, S. & Paolo Pandolfi, P., 17 Aug 2023, In: International Journal of Molecular Sciences . 24, 16, 12870.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Lipid 100%
  • microRNA 22 100%
  • Obesity 66%
  • Maturity Onset Diabetes of the Young 16%
  • Diseases 16%
  5 Citations (Scopus)

  20 Downloads (Pure)

• MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors

  Liu, X., Sempere, L. F., Ouyang, H., Memoli, V. A., Andrew, A. S., Luo, Y., Demidenko, E., Korc, M., Shi, W., Preis, M., Dragnev, K. H., Li, H., Direnzo, J., Bak, M., Freemantle, S. J., Kauppinen, S. & Dmitrovsky, E., 1 Apr 2010, In: Journal of Clinical Investigation. 120, 4, p. 1298-309 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MicroRNA 100%
  • Cancer Cell 100%
  • Mouse 100%
  • Tumor Suppressor Protein 100%
  • Mir-31 88%
  362 Citations (Scopus)

• microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

  Leucci, E., Patella, F., Waage, J., Holmstrøm, K., Lindow, M., Porse, B., Kauppinen, S. & Lund, A. H., 29 Aug 2013, In: Scientific Reports. 3, 6 p., 2535.

  Research output: Contribution to journal › Journal article › Research › peer-review
  218 Citations (Scopus)

• MicroRNA Profiling Identifies MicroRNA-155 as an Adverse Mediator of Cardiac Injury and Dysfunction during Acute Viral MyoCarditis

  Corsten, M. F., Papageorgiou, A., Verhesen, W., Carai, P., Lindow, M., Obad, S., Summer, G., Coort, S. L. M., Hazebroek, M., Van Leeuwen, R., Gijbels, M. J. J., Wijnands, E., Biessen, E. A. L., De Winther, M. P. J., Stassen, F. R. M., Carmeliet, P., Kauppinen, S., Schroen, B. & Heymans, S., 3 Aug 2012, In: Circulation Research. 111, 4, p. 415-425 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mouse 100%
  • Viral Disease 23%
  • Macrophage 23%
  • Normal Human 19%
  • Inflammation 19%
  175 Citations (Scopus)

• MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4

  Sonkoly, E., Janson, P., Majuri, M-L., Savinko, T., Fyhrquist, N., Eidsmo, L., Xu, N., Meisgen, F., Wei, T., Bradley, M., Stenvang, J., Kauppinen, S., Alenius, H., Lauerma, A., Homey, B., Winqvist, O., Ståhle, M. & Pivarcsi, A., 2010, In: Journal of Allergy and Clinical Immunology. 126, 3, p. 581-589.e20 29 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Atopic Dermatitis 100%

• miR-21 is up-regulated in psoriasis and suppresses T cell apoptosis

  Meisgen, F., Xu, N., Wei, T., Janson, P. C., Obad, S., Broom, O., Nagy, N., Kauppinen, S., Kemény, L., Ståhle, M., Pivarcsi, A. & Sonkoly, E., 1 Apr 2012, In: Experimental Dermatology Online. 21, 4, p. 312-314 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • T Cell 100%
  • MicroRNA 100%
  • Apoptosis 100%
  • T Helper Cell 16%
  • Inflammation 16%
  139 Citations (Scopus)

• miRMaid: a unified programming interface for microRNA data resources

  Jacobsen, A., Krogh, A., Kauppinen, S. & Lindow, M., 1 Jan 2010, In: B M C Bioinformatics. 11, 29

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MicroRNA 100%
  • RNA 16%
  15 Citations (Scopus)

• mRNA expression profiling reveals conserved and non-conserved miR-140 targets.

  Nicolas, F. E., Pais, H., Schwach, F., Lindow, M., Kauppinen, S., Moulton, V. & Dalmay, T., 2011, In: RNA Biology. 8, 4, p. 607-615 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Messenger RNA 100%
  • Chondrocyte 50%
  • Small Interfering RNA 33%
  • Gene 33%
  • Gene Expression 33%
  35 Citations (Scopus)

• Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR

  Rottiers, V., Obad, S., Petri, A., McGarrah, R., Lindholm, M. W., Black, J. C., Sinha, S., Goody, R. J., Lawrence, M. S., Delemos, A. S., Hansen, H. F., Whittaker, S., Henry, S., Brookes, R., Najafi-Shoushtari, S. H., Chung, R. T., Whetstine, J. R., Gerszten, R. E., Kauppinen, S. & Näär, A. M., 20 Nov 2013, In: Science Translational Medicine. 5, 212, p. 212ra162

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MicroRNA 100%
  • Insulin 9%
  • Cholesterol 9%
  • Mammalian Cell 9%
  • Defense Mechanism 9%
  105 Citations (Scopus)

• PTENP1-AS contributes to BRAF inhibitor resistance and is associated with adverse clinical outcome in stage III melanoma

  Vidarsdottir, L., Azimi, A., Das, I., Sigvaldadottir, I., Suryo Rahmanto, A., Petri, A., Kauppinen, S., Ingvar, C., Jönsson, G., Olsson, H., Frostvik Stolt, M., Tuominen, R., Sangfelt, O., Pokrovskaja Tamm, K., Hansson, J., Grandér, D., Egyházi Brage, S. & Johnsson, P., 26 May 2021, In: Scientific Reports. 11, 1, 11 p., 11023.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • PTENP1 100%
  • Antisense RNA 16%
  • EZH2 16%
  • Transcription 16%
  6 Citations (Scopus)

  46 Downloads (Pure)

• Regulation of acute graft-versus-host disease by microRNA-155

  Ranganathan, P., Heaphy, C. E. A., Costinean, S., Stauffer, N., Na, C., Hamadani, M., Santhanam, R., Mao, C., Taylor, P. A., Sandhu, S., He, G., Shana'ah, A., Nuovo, G. J., Lagana, A., Cascione, L., Obad, S., Broom, O., Kauppinen, S., Byrd, J. C., Caligiuri, M., & 7 othersPerrotti, D., Hadley, G. A., Marcucci, G., Devine, S. M., Blazar, B. R., Croce, C. M. & Garzon, R., 17 May 2012, In: Blood. 119, 20, p. 4786-4797 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MicroRNA 100%
  • Hematopoietic Stem Cell Transplantation 37%
  • T Cell 27%
  • Lymphocyte 12%
  • T Cell Activation 12%
  123 Citations (Scopus)

• Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice

  Garchow, B. G., Encinas, O. B., Leung, Y. T., Tsao, P. Y., Eisenberg, R. A., Caricchio, R., Obad, S., Petri, A., Kauppinen, S. & Kiriakidou, M., 2011, In: E M B O Molecular Medicine. 3, 10, p. 605-616

  Research output: Contribution to journal › Journal article › Research › peer-review
  168 Citations (Scopus)

• Silencing of microRNA families by seed-targeting tiny LNAs

  Obad, S., Dos Santos, C. O., Petri, A., Heidenblad, M., Broom, O., Ruse, C., Fu, C., Lindow, M., Stenvang, J., Straarup, E. M., Hansen, H. F., Koch, T., Pappin, D., Hannon, G. J. & Kauppinen, S., Apr 2011, In: Nature Genetics. 43, 4, p. 371-378

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Breast 100%
  563 Citations (Scopus)

• Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy

  Bernardo, B. C., Gao, X-M., Tham, Y. K., Kiriazis, H., Winbanks, C. E., Ooi, J. Y. Y., Boey, E. J. H., Obad, S., Kauppinen, S., Gregorevic, P., Du, X-J., Lin, R. C. Y. & McMullen, J. R., 2014, In: P L o S One. 9, 2, e90337.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  • Mouse 100%
  • Hypertrophic Cardiomyopathy 100%
  • Pressure Overload 42%
  • Hypertrophy 28%
  • Echocardiography 14%
  71 Citations (Scopus)

• Silencing of the miR-17~92 Cluster Family Inhibits Medulloblastoma Progression

  Murphy, B. L., Obad, S., Bihannic, L., Ayrault, O., Zindy, F., Kauppinen, S. & Roussel, M. F., 1 Dec 2013, In: Cancer Research. 73, 23, p. 7068-78 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Medulloblastoma 100%
  • Sonic Hedgehog 100%
  • MicroRNA 42%
  • Allotransplantation 25%
  • Transplant Procedure 25%
  115 Citations (Scopus)

• Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice

  Patrick, D. M., Montgomery, R. L., Qi, X., Obad, S., Kauppinen, S., Hill, J. A., van Rooij, E. & Olson, E. N., 1 Nov 2010, In: Journal of Clinical Investigation. 120, 11, p. 3912-3916 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  322 Citations (Scopus)

• Systematic Analysis of Long Non-Coding RNA Genes in Nonalcoholic Fatty Liver Disease

  Ilieva, M., Dao, J., Miller, H. E., Madsen, J. H., Bishop, A. J. R., Kauppinen, S. & Uchida, S., 22 Jul 2022, In: Non-coding RNA. 8, 4, 16 p., 56.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Long Non-Coding RNA 100%
  • Non-Alcoholic Fatty Liver Disease 100%
  • Liver 100%
  • Gene 50%
  • Long Noncoding RNA 33%
  9 Citations (Scopus)

  36 Downloads (Pure)

• Targeting of microRNA-22 Suppresses Tumor Spread in a Mouse Model of Triple-Negative Breast Cancer

  Panella, R., Cotton, C. A., Maymi, V. A., Best, S., Berry, K. E., Lee, S., Batalini, F., Vlachos, I. S., Clohessy, J. G., Kauppinen, S. & Paolo Pandolfi, P., 18 May 2023, In: Biomedicines. 11, 5, 1470.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • microRNA 22 100%
  • Metastatic Carcinoma 100%
  • Triple Negative Breast Cancer 100%
  • Mouse Model 100%
  • MicroRNA 100%
  17 Downloads (Pure)

• The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

  Castoldi, M., Spasic, M. V., Altamura, S., Elmén, J., Lindow, M., Kiss, J., Stolte, J., Sparla, R., D'Alessandro, L. A., Klingmüller, U., Fleming, R. E., Longerich, T., Gröne, H. J., Benes, V., Kauppinen, S., Hentze, M. W. & Muckenthaler, M. U., Apr 2011, In: Journal of Clinical Investigation. 121, 4, p. 1386-1396 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • microRNA 122 100%
  • microRNA 100%
  • Iron Homeostasis 100%
  • Liver 100%
  • MicroRNA 100%
  203 Citations (Scopus)

• The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

  Papaioannou, D., Petri, A., Dovey, O. M., Terreri, S., Wang, E., Collins, F. A., Woodward, L. A., Walker, A. E., Nicolet, D., Pepe, F., Kumchala, P., Bill, M., Walker, C. J., Karunasiri, M., Mrózek, K., Gardner, M. L., Camilotto, V., Zitzer, N., Cooper, J. L., Cai, X., & 13 othersRong-Mullins, X., Kohlschmidt, J., Archer, K. J., Freitas, M. A., Zheng, Y., Lee, R. J., Aifantis, I., Vassiliou, G., Singh, G., Kauppinen, S., Bloomfield, C. D., Dorrance, A. M. & Garzon, R., 25 Nov 2019, In: Nature Communications. 10, 1, 15 p., 5351.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Ribosomal RNA 100%
  • Long Non-Coding RNA 100%
  • Binding Protein 50%
  • Ribosomal DNA 25%
  • Long Noncoding RNA 25%
  73 Citations (Scopus)

  88 Downloads (Pure)

• Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function

  Bernardo, B. C., Gao, X., Winbanks, C. E., Boey, E. J. H., Tham, Y., Kiriazis, H., Gregorevic, P., Obad, S., Kauppinen, S., Du, X., Lin, R. C. Y. & McMullen, J. R., 23 Oct 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 43, p. 17615-17620 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MicroRNA 100%
  • Vascular Endothelial Growth Factor 33%
  • Atrial Natriuretic Peptide 33%
  • Semaphorin 33%
  • ATPase 33%
  381 Citations (Scopus)

• Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

  Lanford, R. E., Hildebrandt-Eriksen, E. S., Petri, A., Persson, R., Lindow, M., Munk, M. E., Kauppinen, S. & Ørum, H., 8 Jan 2010, In: Science. 327, 5962, p. 198-201 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • microRNA 122 100%
  • Chronic Hepatitis C 100%
  • Viral Disease 100%
  • Primate 100%
  • Miravirsen 50%
  1519 Citations (Scopus)

• The therapeutic potential of MicroRNAs in cancer

  Thorsen, S., Obad, S., Jensen, N. F., Stenvang, J. & Kauppinen, S., 1 May 2012, In: Cancer Journal. 18, 3, p. 275-284 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MicroRNA 100%
  • Oncogene 33%
  • Antisense 33%
  • Tumor Suppressor Protein 18%
  • Oligonucleotide 9%
  101 Citations (Scopus)

• Transcriptome dynamics of the microRNA inhibition response

  Wen, J., Leucci, E., Vendramin, R., Kauppinen, S., Lund, A. H., Krogh, A. & Parker, B. J., 2015, In: Nucleic Acids Research. 43, 13, p. 6207-6221 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  • Dynamics 100%
  • Inhibition 100%
  • Transcriptome 100%
  • Processing 33%
  • RNA 25%
  5 Citations (Scopus)