Projects per year
Personal profile
Research profile
René Ernst Nielsen, Professor, Chief Physician, PhD
René Ernst Nielsen is Professor of Psychiatry at Aalborg University and Chief Physician at Psychiatry – Aalborg University Hospital. His research focuses on affective disorders, including bipolar disorder and treatment-resistant depression, as well as somatic comorbidity and excess mortality among individuals with severe mental illness. He currently leads two of the four adult psychiatry research programs at Aalborg University Hospital: one on affective disorders and another on morbidity and mortality.
He has authored more than 110 peer-reviewed publications and is an active member of several national and international research networks, including the ECNP Bipolar Network and PAN-HEalth group, as well as the International Society for Bipolar Disorders. Since 2022, he has served as President of the International Group for the Study of Lithium Treated Patients (IGSLI), and he holds multiple positions of trust in psychiatric academic and diagnostic committees.
René Ernst Nielsen is a regular peer reviewer for top-tier journals including JAMA Psychiatry, Molecular Psychiatry, and Schizophrenia Bulletin. He has served as associate editor for Nordic Journal of Psychiatry and BMC Psychiatry and is on the editorial boards of several international journals. He supervises PhD students and teaches medical students in both clinical settings and research methodology.
His clinical research includes several large-scale trials, most recently as principal investigator in a phase III trial on psilocybin for major depressive disorder.
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Collaborations from the last five years
Projects
- 2 Finished
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Funktionelle anfald hos børn og unge
Hansen, A. S. (PI), Christensen, J. (CoI), Rask, C. U. (CoI) & Nielsen, R. E. (CoI)
01/09/2016 → 01/09/2020
Project: Research
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Åreforkalkning som årsag til sygelighed og dødelighed hos patienter med skizofreni: Epidemiologi og status med henblik på forebyggelsestiltag og behandling
Aagaard, J. (Project Manager), Jensen, S. E. (Project Manager) & Nielsen, R. E. (Project Manager)
01/10/2014 → 30/06/2021
Project: Research
Research output
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Does Lithium Lower the Risk of Glaucoma—A Danish Nationwide Study
Hajek, T., Forlenza, O., Nicolela, M., Christensen, A. E., Vorum, H. & Nielsen, R. E., Oct 2025, In: Acta Psychiatrica Scandinavica. 152, 4, p. 308-315 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Downloads (Pure) -
Efficacy of esketamine nasal spray over quetiapine extended release over the short and long term: sensitivity analyses of ESCAPE-TRD, a randomised phase IIIb clinical trial
Young, A. H., Llorca, P.-M., Fagiolini, A., Falkai, P., Cardoner, N., Nielsen, R. E., Blomqvist, O., Godinov, Y., Rive, B., Diels, J., Mulhern-Haughey, S. & Reif, A., Feb 2025, In: British Journal of Psychiatry. 226, 2, p. 72-78 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)40 Downloads (Pure) -
Lithium versus cariprazine in the acute phase treatment for depressive episodes in patients with bipolar disorder: A protocol for a pragmatic open, randomised multicentre study - The 9th trial of the Danish University Antidepressant Group, DUAG-9
Hovgesen, S. V., Licht, R. W. W., Straszek, S. P. V., Christensen, A. E., Vinberg, M., Videbech, P., Miskowiak, K. W., Johnsen, S., Munk, M. M., Mai, M. L., Baethge, C., Kessing, L. V. & Nielsen, R. E., 27 Aug 2025, In: BMJ Open. 15, 8, 9 p., e102406.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile64 Downloads (Pure) -
Prevalence of cardiovascular risk factors and disease in patients with schizophrenia: baseline results from a prospective cohort study with long-term clinical follow-up
Polcwiartek, C., Jensen, S. E., Frøkjær, J. B. & Nielsen, R. E., Jul 2025, In: Schizophrenia. 11, 6 p., 95.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus) -
Real-world treatment outcomes of transcranial pulsating electromagnetic fields as augmentation therapy for treatment-resistant depression
Jensen, R. H., Nielsen, R. E. & Bizik, G., 1 Jan 2025, In: Journal of Affective Disorders. 368, p. 487-492 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile97 Downloads (Pure)
Datasets
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Additional file 2 of Differences in bacterial taxa between treatment-naive patients with major depressive disorder and non-affected controls may be related to a proinflammatory profile
Knudsen, J. K. (Creator), Bundgaard-Nielsen, C. (Creator), Leutscher, P. (Creator), Hjerrild, S. (Creator), Nielsen, R. E. (Creator) & Sørensen, S. (Creator), Figshare, 14 Aug 2024
DOI: 10.6084/m9.figshare.25124089.v1, https://springernature.figshare.com/articles/figure/Additional_file_2_of_Differences_in_bacterial_taxa_between_treatment-naive_patients_with_major_depressive_disorder_and_non-affected_controls_may_be_related_to_a_proinflammatory_profile/25124089/1
Dataset: Supplementary material
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Additional file 3 of Differences in bacterial taxa between treatment-naive patients with major depressive disorder and non-affected controls may be related to a proinflammatory profile
Knudsen, J. K. (Creator), Bundgaard-Nielsen, C. (Creator), Leutscher, P. (Creator), Hjerrild, S. (Creator), Nielsen, R. E. (Creator) & Sørensen, S. (Creator), Figshare, 14 Aug 2024
DOI: 10.6084/m9.figshare.26675216, https://springernature.figshare.com/articles/figure/Additional_file_3_of_Differences_in_bacterial_taxa_between_treatment-naive_patients_with_major_depressive_disorder_and_non-affected_controls_may_be_related_to_a_proinflammatory_profile/26675216
Dataset: Supplementary material
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Additional file 5 of Differences in bacterial taxa between treatment-naive patients with major depressive disorder and non-affected controls may be related to a proinflammatory profile
Knudsen, J. K. (Creator), Bundgaard-Nielsen, C. (Creator), Leutscher, P. (Creator), Hjerrild, S. (Creator), Nielsen, R. E. (Creator) & Sørensen, S. (Creator), Figshare, 14 Aug 2024
DOI: 10.6084/m9.figshare.26675222.v1, https://springernature.figshare.com/articles/figure/Additional_file_5_of_Differences_in_bacterial_taxa_between_treatment-naive_patients_with_major_depressive_disorder_and_non-affected_controls_may_be_related_to_a_proinflammatory_profile/26675222/1
Dataset: Supplementary material
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Additional file 7 of Differences in bacterial taxa between treatment-naive patients with major depressive disorder and non-affected controls may be related to a proinflammatory profile
Knudsen, J. K. (Creator), Bundgaard-Nielsen, C. (Creator), Leutscher, P. (Creator), Hjerrild, S. (Creator), Nielsen, R. E. (Creator) & Sørensen, S. (Creator), Figshare, 14 Aug 2024
DOI: 10.6084/m9.figshare.26675228.v1, https://springernature.figshare.com/articles/figure/Additional_file_7_of_Differences_in_bacterial_taxa_between_treatment-naive_patients_with_major_depressive_disorder_and_non-affected_controls_may_be_related_to_a_proinflammatory_profile/26675228/1
Dataset: Supplementary material
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Additional file 6 of Differences in bacterial taxa between treatment-naive patients with major depressive disorder and non-affected controls may be related to a proinflammatory profile
Knudsen, J. K. (Creator), Bundgaard-Nielsen, C. (Creator), Leutscher, P. (Creator), Hjerrild, S. (Creator), Nielsen, R. E. (Creator) & Sørensen, S. (Creator), Figshare, 14 Aug 2024
DOI: 10.6084/m9.figshare.26675225.v1, https://springernature.figshare.com/articles/figure/Additional_file_6_of_Differences_in_bacterial_taxa_between_treatment-naive_patients_with_major_depressive_disorder_and_non-affected_controls_may_be_related_to_a_proinflammatory_profile/26675225/1
Dataset: Supplementary material
Activities
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Aalborg University (Organisational unit)
Nielsen, R. E. (Member)
1 May 2020Activity: Memberships › Membership of research networks or expert groups
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Aalborg University (Organisational unit)
Nielsen, R. E. (Member)
1 Dec 2019Activity: Memberships › Membership of committees, commissions, boards, councils, associations, organisations, or similar
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Aalborg University (Organisational unit)
Nielsen, R. E. (Member)
1 Dec 2019Activity: Memberships › Membership of committees, commissions, boards, councils, associations, organisations, or similar
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Diagnoseudvalg Dansk Psykiatrisk Selskab (External organisation)
Nielsen, R. E. (Chairperson)
1 Dec 2019Activity: Memberships › Membership of research networks or expert groups
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ECNP Bipolar Network (External organisation)
Nielsen, R. E. (Member)
1 Dec 2018Activity: Memberships › Membership of research networks or expert groups
Press/Media
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Debat: Tiden er kommet til at handle på tidens største ulighedsproblem
Knudsen, S. V., Mackenhauer, J., Mainz, J., Johnsen, S. P., Terp, M., Polcwiartek, C. B. & Nielsen, R. E.
19/01/2026
1 item of Media coverage
Press/Media: Press / Media
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MDMA-terapi mod PTSD i Danmark: Forskere får knap 6 millioner kroner til stort forsøg
25/11/2025
1 item of Media coverage
Press/Media: Press / Media
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Litium kan måske blive et effektivt våben mod Alzheimers sygdom
16/11/2025
1 item of Media coverage
Press/Media: Press / Media
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Vildt gennembrud: Litium, som findes i genopladelige batterier, kan måske blive et effektivt våben mod Alzheimers sygdom
08/11/2025 → 12/11/2025
2 items of Media coverage
Press/Media: Press / Media
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Sammenhæng mellem lithium og Alzheimers sygdom
15/09/2025
1 item of Media coverage
Press/Media: Press / Media
Impacts
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Psilocybin for depression increases quality of life
Nielsen, R. E. (Participant) & Licht, R. W. (Participant)
Impact: Quality of life impact