Photo of Malene Bredal Brohus
  • Fredrik Bajers Vej 7, H, 1-534

    9220 Aalborg

    Denmark

20152019
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  • 11 Similar Profiles
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Research Output 2015 2019

  • 8 Journal article
  • 1 Ph.D. thesis
3 Citations (Scopus)
95 Downloads (Pure)

Ca2+ dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains

Brohus, M., Søndergaard, M. T., Chen, W. S. R., Van Petegem, F. & Overgaard, M. T., 18 Jan 2019, In : Biochemical Journal. 476, 2, p. 193-209

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Ryanodine Receptor Calcium Release Channel
Calmodulin
Fluorescence Polarization
Sensors
Clamping devices
1 Citation (Scopus)

Diminished inhibition and facilitated activation of RyR2-mediated Ca2+ release is a common defect of arrhythmogenic calmodulin mutations

Søndergaard, M. T., Liu, Y., Brohus, M., Guo, W., Nani, A., Carvajal, C., Fill, M., Overgaard, M. T. & Chen, S. R. W., 23 Jun 2019, In : F E B S Journal.

Research output: Contribution to journalJournal articleResearchpeer-review

Ryanodine Receptor Calcium Release Channel
Calmodulin
Mutation
HEK293 Cells
Cardiac Arrhythmias

Role of cardiac ryanodine receptor calmodulin-binding domains in mediating the action of arrhythmogenic calmodulin N-domain mutation N54I

Søndergaard, M. T., Liu, Y., Guo, W., Wei, J., Wang, R., Brohus, M., Overgaard, M. T. & Chen, S. R. W., 25 Nov 2019, In : The FEBS Journal.

Research output: Contribution to journalJournal articleResearchpeer-review

Ryanodine Receptor Calcium Release Channel
Calmodulin
Mutation
HEK293 Cells
4 Citations (Scopus)

Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel

Wang, K., Holt, C., Lu, J., Brohus, M., Larsen, K. T., Overgaard, M. T., Wimmer, R. & Van Petegem, F., 6 Nov 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 45, p. E10556-E10565 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Calmodulin
Calcium Channels
Cardiac Arrhythmias
Mutation
EF Hand Motifs
8 Citations (Scopus)
73 Downloads (Pure)

Human calmodulin mutations

Jensen, H. H., Brohus, M., Nyegaard, M. & Overgaard, M. T., 13 Nov 2018, In : Frontiers in Molecular Neuroscience. 11, 9 p., 396.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Calmodulin
Mutation
Ryanodine Receptor Calcium Release Channel
Phenotype
Cardiac Arrhythmias

Activities 2018 2018

  • 1 Conference presentations

The F141L mutation in human calmodulin disrupts the structure and leads to misregulation of a voltage-gated cardiac calcium channel

Christian Holt (Other), Malene Bredal Brohus (Other), Kaiqian Wang (Other), Filip Van Petegem (Other), Michael Toft Overgaard (Other), Reinhard Wimmer (Lecturer)
19 Aug 201824 Aug 2018

Activity: Talks and presentationsConference presentations

Press / Media

Ph.d.-grad

Malene Brohus

26/06/2018

1 item of Media coverage

Press/Media: Press / Media