Research Output per year
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- 11 Similar Profiles
Calmodulin
Medicine & Life Sciences
Ryanodine Receptor Calcium Release Channel
Medicine & Life Sciences
Mutation
Medicine & Life Sciences
Somatomedins
Chemical Compounds
insulin-like growth factor binding proteins
Agriculture & Biology
somatomedins
Agriculture & Biology
Insulin-Like Growth Factor Binding Proteins
Medicine & Life Sciences
Mole Rats
Medicine & Life Sciences
Network
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Research Output 2015 2019
3
Citations
(Scopus)
95
Downloads
(Pure)
Ca2+ dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains
Brohus, M., Søndergaard, M. T., Chen, W. S. R., Van Petegem, F. & Overgaard, M. T., 18 Jan 2019, In : Biochemical Journal. 476, 2, p. 193-209Research output: Contribution to journal › Journal article › Research › peer-review
Open Access
File
Ryanodine Receptor Calcium Release Channel
Calmodulin
Fluorescence Polarization
Sensors
Clamping devices
1
Citation
(Scopus)
Diminished inhibition and facilitated activation of RyR2-mediated Ca2+ release is a common defect of arrhythmogenic calmodulin mutations
Søndergaard, M. T., Liu, Y., Brohus, M., Guo, W., Nani, A., Carvajal, C., Fill, M., Overgaard, M. T. & Chen, S. R. W., 23 Jun 2019, In : F E B S Journal.Research output: Contribution to journal › Journal article › Research › peer-review
Ryanodine Receptor Calcium Release Channel
Calmodulin
Mutation
HEK293 Cells
Cardiac Arrhythmias
Role of cardiac ryanodine receptor calmodulin-binding domains in mediating the action of arrhythmogenic calmodulin N-domain mutation N54I
Søndergaard, M. T., Liu, Y., Guo, W., Wei, J., Wang, R., Brohus, M., Overgaard, M. T. & Chen, S. R. W., 25 Nov 2019, In : The FEBS Journal.Research output: Contribution to journal › Journal article › Research › peer-review
Ryanodine Receptor Calcium Release Channel
Calmodulin
Mutation
HEK293 Cells
4
Citations
(Scopus)
Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel
Wang, K., Holt, C., Lu, J., Brohus, M., Larsen, K. T., Overgaard, M. T., Wimmer, R. & Van Petegem, F., 6 Nov 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 45, p. E10556-E10565 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access
Calmodulin
Calcium Channels
Cardiac Arrhythmias
Mutation
EF Hand Motifs
8
Citations
(Scopus)
73
Downloads
(Pure)
Human calmodulin mutations
Jensen, H. H., Brohus, M., Nyegaard, M. & Overgaard, M. T., 13 Nov 2018, In : Frontiers in Molecular Neuroscience. 11, 9 p., 396.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access
File
Calmodulin
Mutation
Ryanodine Receptor Calcium Release Channel
Phenotype
Cardiac Arrhythmias
Activities 2018 2018
- 1 Conference presentations
The F141L mutation in human calmodulin disrupts the structure and leads to misregulation of a voltage-gated cardiac calcium channel
Christian Holt (Other), Malene Bredal Brohus (Other), Kaiqian Wang (Other), Filip Van Petegem (Other), Michael Toft Overgaard (Other), Reinhard Wimmer (Lecturer)19 Aug 2018 → 24 Aug 2018
Activity: Talks and presentations › Conference presentations
Press / Media
En genfejl, der går lige i hjertet
Michael Toft Overgaard, Helene Halkjær Jensen & Malene Bredal Brohus
07/05/2019
1 item of Media coverage
Press/Media: Press / Media