Malene Bredal Brohus

Postdoc, Department of Chemistry and Bioscience
Postdoc, The Faculty of Engineering and Science
Postdoc, Section of Biotechnology
Medical Biotechnology

Phone9940 3599, 6177 8817
Emailmbrohus@bio.aau.dk

Fredrik Bajers Vej 7, H, 1-534
9220 Aalborg
Denmark

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11 Journal article
1 Ph.D. thesis
1 Poster

Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca²⁺ binding and cause misfolding
Wang, K., Brohus, M., Holt, C., Overgaard, M. T., Wimmer, R. & Van Petegem, F., Mar 2020, In : The Journal of Physiology. 598, 6, p. 1169-1186 18 p.
Research output: Contribution to journal › Journal article › Research › peer-review
2 Citations (Scopus)
Infanticide vs. inherited cardiac arrhythmias
Brohus, M., Arsov, T., Wallace, D. A., Jensen, H. H., Nyegaard, M., Crotti, L., Adamski, M., Zhang, Y., Field, M. A., Athanasopoulos, V., Baró, I., Ribeiro de Oliveira-Mendes, B. B., Redon, R., Charpentier, F., Raju, H., DiSilvestre, D., Wei, J., Wang, R., Rafehi, H., Kaspi, A. & 7 others, Bahlo, M., Dick, I. E., Chen, S. R. W., Cook, M. C., Vinuesa, C. G., Overgaard, M. T. & Schwartz, P. J., 17 Nov 2020, In : Europace.
Research output: Contribution to journal › Journal article › Research › peer-review

Open Access
The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor
Holt, C., Hamborg, L., Lau, K., Brohus, M., Sørensen, A. B., Larsen, K. T., Sommer, C., Van Petegem, F., Overgaard, M. T. & Wimmer, R., 29 May 2020, In : Journal of Biological Chemistry. 295, 22, p. 7620-7634 15 p.
Research output: Contribution to journal › Journal article › Research › peer-review
A novel mutation in calmodulin causes dysregulation of calcium channels
Jensen, H. H., Brohus, M. B., Dick, I. E., Søndergaard, M. T., Liu, Y., Chen, W. S. R., Nyegaard, M., Kjærulf Jensen, H. & Overgaard, M. T., 18 Sep 2019.
Research output: Contribution to conference without publisher/journal › Poster › Research
Ca²⁺ dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains
Brohus, M., Søndergaard, M. T., Chen, W. S. R., Van Petegem, F. & Overgaard, M. T., 18 Jan 2019, In : Biochemical Journal. 476, 2, p. 193-209 17 p.
Research output: Contribution to journal › Journal article › Research › peer-review

Open Access
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6 Citations (Scopus)

179 Downloads (Pure)

1 Conference presentations

The F141L mutation in human calmodulin disrupts the structure and leads to misregulation of a voltage-gated cardiac calcium channel
Christian Holt (Other), Malene Bredal Brohus (Other), Kaiqian Wang (Other), Filip Van Petegem (Other), Michael Toft Overgaard (Other) & Reinhard Wimmer (Lecturer)
19 Aug 2018 → 24 Aug 2018
Activity: Talks and presentations › Conference presentations

Australsk mor dømt for at slå sine fire børn ihjel: Nu sætter danske forskere spørgsmålstegn ved dommen
Malene Brohus, Helene Halkjær Jensen & Michael Toft Overgaard
20/08/2020
1 item of Media coverage
Press/Media: Press / Media
En genfejl, der går lige i hjertet
Michael Toft Overgaard, Helene Halkjær Jensen & Malene Bredal Brohus
07/05/2019
1 item of Media coverage
Press/Media: Press / Media
Ph.d.-grad
Malene Brohus
26/06/2018
1 item of Media coverage
Press/Media: Press / Media