Peter Kristensen

PhD, Head of Section for Biotechnology

  • Fredrik Bajers Vej 7, H, 1-532

    9220 Aalborg

    Denmark

1993 …2019
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Personal profile

Research profile

The research of Peter Kristensen is centered on the technical development and application of methods that allow Darwinian evolution of proteins using directed evolution technologies.

The main scientific contributions have more specifically been in the area of recombinant antibodies and methods of isolating such antibodies from large libraries. In addition Peter Kristensen was the first to develop technologies which allow isolation of proteins with improved stabilities from large libraries of mutants. The interest to make technological developments based on recombinant antibodies and for manipulating protein stability and activity, were initiated while Peter Kristensen performed his post doc at the MRC-LMB in Cambridge in the group of Nobel Laureate Sir Greg Winter.  However to justify technological development, the technology developed should be able to provide new insight or solve important problems and here we have especially focused attention at finding novel biomarkers which can be used in characterization of important human conditions, such as age related diseases and rare circulating cells in the blood, just to mention the most relevant example. Most recently, the research has involved the use of non-natural amino acids for immobilization and conjugation of recombinant antibodies and proteins of industrial interest and novel biosensors building on recombinant antibody technology.

Education/Academic qualification

Chemistry and Biotechnology, PhD, Department of Chemistry, University of Aarhus, Aarhus

19922 Oct 1995

Chemistry and Biotechnology, MSc, Aarhus University

1 Sep 198630 Jun 1992

External positions

Associate Professor (MSK), Department of Engineering, Aarhus University, Gustav Wieds Vej 10C, Aarhus C, DK-8000, Denmark.

20102017

Associate Professor (MSK), Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10, Aarhus, Denmark.

20032010

Senior Scientist, Aarhus Universityhospital, Denmark

20012002

Research Associate Professor, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10, Aarhus, Denmark.

20002001

Research Assistant Professor, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10, Aarhus, Denmark.

19982000

Research Scientist, Medical Research Council Centre, Laboratory for Molecular Biology (MRC-LMB)

19971998

Post-doctoral Fellow, Medical Research Council Centre, Laboratory for Molecular Biology (MRC-LMB)

19951997

Keywords

  • Chemistry and Bioscience
  • Protein Science
  • protein engineering
  • aging
  • biomarkers
  • antibody engineering
  • phage display
  • cancer stem cells
  • Biomedicine

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Research Output 1993 2019

3 Citations (Scopus)

An anti vimentin antibody promotes tube formation

Jørgensen, M. L., Møller, C. K., Rasmussen, L., Boisen, L., Pedersen, H. & Kristensen, P., 15 Jun 2017, In : Scientific Reports. 7, 1, 3576.

Research output: Contribution to journalJournal articleResearchpeer-review

Vimentin
Anti-Idiotypic Antibodies
Endothelial Cells
Antibodies
Antibody Binding Sites
3 Citations (Scopus)

Pericyte modulation by a functional antibody obtained by a novel single-cell selection strategy

Just, J., Lykkemark, S., Nielsen, C. H., Roshenas, A. R., Drasbek, K. R., Petersen, S. V., Bek, T. & Kristensen, P., 1 Aug 2017, In : Microcirculation. 24, 6, e12365.

Research output: Contribution to journalJournal articleResearchpeer-review

Pericytes
Antibodies
Epitopes
Fibronectins
Blood Vessels
2 Citations (Scopus)

A novel excision selection method for isolation of antibodies binding antigens expressed specifically by rare cells in tissue sections

Lykkemark, S., Mandrup, O. A., Jensen, M. B., Just, J. & Kristensen, P., 1 Jun 2017, In : Nucleic Acids Research. 45, 11, p. e107

Research output: Contribution to journalJournal articleResearchpeer-review

Antigens
Antibodies
Nucleic Acids
Biomarkers
Immunohistochemistry
10 Citations (Scopus)

Identification of an unstable 4-hydroxynoneal modification on the 20S proteasome subunit α7 by recombinant antibody technology.

Just, J., Jung, T., Friis, N. A., Lykkemark, S., Drasbek, K., Siboska, G., Grune, T. & Kristensen, P., 1 Dec 2015, In : Free Radical Biology and Medicine. 89, p. 786-792 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Proteasome Endopeptidase Complex
Oxidative stress
Technology
Antibodies
Oxidative Stress

Insight into the structure and activity of surface-engineered lipase biofluids

Zhou, Y., Jones, N. C., Pedersen, J. N., Pérez, B., Hoffmann, S. V., Petersen, S. V., Pedersen, J. S., Perriman, A., Kristensen, P., Gao, R. & Guo, Z., 9 Jan 2019, In : ChemBioChem.

Research output: Contribution to journalJournal articleResearchpeer-review

Lipase
Bacilli
Bacillus subtilis
Enzymes
Mutagenesis

Activities 2019 2019

File

Introduction to Omics

Peter Kristensen (Lecturer)
14 Sep 201929 Sep 2019

Activity: Talks and presentationsExternal teaching and course activities at other universities

Single cell selections of recombinant antibodies binding to circulating tumor cells

Peter Kristensen (Lecturer)
5 Jul 2019

Activity: Talks and presentationsConference presentations

Establishing a method for incorporation of artificial amino acids in plants

Peter Kristensen (External examiner)
3 Jul 2019

Activity: ExaminationExternal examination