Peter Kristensen

PhD, Head of Section for Biotechnology

  • Fredrik Bajers Vej 7, H, 1-532

    9220 Aalborg

    Denmark

1993 …2020

Research output per year

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Personal profile

Research profile

The research of Peter Kristensen is centered on the technical development and application of methods that allow Darwinian evolution of proteins using directed evolution technologies.

The main scientific contributions have more specifically been in the area of recombinant antibodies and methods of isolating such antibodies from large libraries. In addition Peter Kristensen was the first to develop technologies which allow isolation of proteins with improved stabilities from large libraries of mutants. The interest to make technological developments based on recombinant antibodies and for manipulating protein stability and activity, were initiated while Peter Kristensen performed his post doc at the MRC-LMB in Cambridge in the group of Nobel Laureate Sir Greg Winter.  However to justify technological development, the technology developed should be able to provide new insight or solve important problems and here we have especially focused attention at finding novel biomarkers which can be used in characterization of important human conditions, such as age related diseases and rare circulating cells in the blood, just to mention the most relevant example. Most recently, the research has involved the use of non-natural amino acids for immobilization and conjugation of recombinant antibodies and proteins of industrial interest and novel biosensors building on recombinant antibody technology.

PhD Supervision

Name

Title of Thesis

University of Enrolment

Year

Role

Svend Kjær

Use of phage displayed repertoires in the study of eukaryotic elongation factor 1A

Aarhus University

1998

Project Supervisor

Henrik Sølvsten

Detection and Regulation of the Vitamin D Receptor

Aarhus University

(Faculty of Health)

1998

Co-Supervisor

Troels Wind

Phage Display as a tool for elucidation of Ras biology

Aarhus University

1999

Project Supervisor

Brian Stausbøl-Grøn

solation and Characterisation of Recombinant Human Antibody Fragments From Phage Display Antibody Libraries

Aarhus University (Faculty of Health)

1999

Co-Supervisor

Kristian Hobolt Jensen

Application of phage display and understanding of the infection process

Aarhus University

2000

Project Supervisor

Kim Bak Jensen

Identification of Keratinocyte Specific Markers Using Phage Display

Aarhus University

2002

Project Supervisor

Charlotte Georgi Jakobsen

Establishment of human and murine IgE and IgG combinatorial phage libraries

Aarhus University

2003

Project Supervisor

Martin Larsen

Studies on immune presenting systems with potential of improving vaccines

Aarhus University

2004

Project Supervisor

Potjamas Pansri

Production of Antibody by phage display technology

Suranaree University of Technology, Thailand

2008

Co-Supervisor

Lu Sang

Phage antibody Technology Applied to Identify New Molecular Targets on LM-332 Positive Malignant Cells

Aarhus University

2008

Project Supervisor

Louise Boisen

Using phage display to investigate age-related changes in the proteome and their influence on angiogenesis

Aarhus University

2009

Project Supervisor

Morten Dræby Sørensen

Selection of antibodies by phage display against rare circulating cells in the peripheral bloodstream

Aarhus Univesity

2010

Supervisor

Ole Aalund Mandrup

Phage Display Libraries, Selections and Screenings for the Identification of Internalizing Antibodies and Cellular Markers

Aarhus University

2012

Supervisor

Theresa Meldgaard

Discovery of Cell Specific Biomarkers in Breast Cancer using Recombinant Antibodies

Aarhus University

2013

(2014 due to maternatiy leave

Supervisor

Lotte Rasmussen

Tracing vasculogenesis in tumours – with special emphasis on characterisation and involvement of endothelial outgrowth cells

Aarhus University

2014

Co-supervisor

Simon Asbjørn Larsen

Identification and Analysis of Cell-specific Biomarkers of Breast Cancer Subpopulations by Recombinant antibody selection

Aarhus University

2014

Supervisor

Jesper Just

Exploration of the Pericyte and Oxidative Stress by Recombinant Antibody Technology

Aarhus University

2015

Supervisor

Niels Anton Friis

 

Aarhus University

2014

Supervisor

SimonLykkemark

A Novel Phage Display Selection Method for Pericyte Marker Discovery

Aarhus University

2016

Supervisor

Mathias Lindh Jørgensen

Identification and Exploration of Biomarkers associated to circulating tumour cells by recombinant antibody technology

Aarhus Universitet

2017

Supervisor

Emil Frank Holmquist

Organic Reaction-Based Capture ELISA: Development of High-Throughput Screening Assays for Acetoacetate and Methylglyoxal

Aarhus University

2016

Co-supervisor

Rasmus Kold-Christensen

 

 

2019

Co-supervisor

Education/Academic qualification

Chemistry and Biotechnology, PhD, Department of Chemistry, University of Aarhus, Aarhus

19922 Oct 1995

Award Date: 2 Oct 1995

Chemistry and Biotechnology, MSc, Aarhus University

1 Sep 198630 Jun 1992

Award Date: 1 Jun 1992

External positions

Associate Professor (MSK), Department of Engineering, Aarhus University, Gustav Wieds Vej 10C, Aarhus C, DK-8000, Denmark.

20102017

Associate Professor (MSK), Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10, Aarhus, Denmark.

20032010

Senior Scientist, Aarhus Universityhospital, Denmark

20012002

Research Associate Professor, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10, Aarhus, Denmark.

20002001

Research Assistant Professor, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10, Aarhus, Denmark.

19982000

Research Scientist, Medical Research Council Centre, Laboratory for Molecular Biology (MRC-LMB)

19971998

Post-doctoral Fellow, Medical Research Council Centre, Laboratory for Molecular Biology (MRC-LMB)

19951997

Keywords

  • Chemistry and Bioscience
  • Protein Science
  • protein engineering
  • aging
  • biomarkers
  • antibody engineering
  • phage display
  • cancer stem cells
  • Biomedicine

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Research Output

An anti vimentin antibody promotes tube formation

Jørgensen, M. L., Møller, C. K., Rasmussen, L., Boisen, L., Pedersen, H. & Kristensen, P., 15 Jun 2017, In : Scientific Reports. 7, 1, 3576.

Research output: Contribution to journalJournal articleResearchpeer-review

  • 3 Citations (Scopus)

    Pericyte modulation by a functional antibody obtained by a novel single-cell selection strategy

    Just, J., Lykkemark, S., Nielsen, C. H., Roshenas, A. R., Drasbek, K. R., Petersen, S. V., Bek, T. & Kristensen, P., 1 Aug 2017, In : Microcirculation. 24, 6, e12365.

    Research output: Contribution to journalJournal articleResearchpeer-review

  • 3 Citations (Scopus)

    A novel excision selection method for isolation of antibodies binding antigens expressed specifically by rare cells in tissue sections

    Lykkemark, S., Mandrup, O. A., Jensen, M. B., Just, J. & Kristensen, P., 1 Jun 2017, In : Nucleic Acids Research. 45, 11, p. e107

    Research output: Contribution to journalJournal articleResearchpeer-review

  • 3 Citations (Scopus)

    Identification of an unstable 4-hydroxynoneal modification on the 20S proteasome subunit α7 by recombinant antibody technology.

    Just, J., Jung, T., Friis, N. A., Lykkemark, S., Drasbek, K., Siboska, G., Grune, T. & Kristensen, P., 1 Dec 2015, In : Free Radical Biology and Medicine. 89, p. 786-792 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  • 11 Citations (Scopus)

    Fatty acid hydratase for value-added biotransformation: A review

    Zhang, Y., Eser, B. E., Kristensen, P. & Guo, Z., Aug 2020, In : Chinese Journal of Chemical Engineering. 28, 8, p. 2051-2063 13 p.

    Research output: Contribution to journalReview articleResearchpeer-review

  • Activities

    Press / Media

    Se video: Her er, hvad du skal vide om coronavirussen

    Peter Kristensen

    31/01/2020

    1 item of Media coverage

    Press/Media: Press / Media

    Molecular Engineering

    Peter Kristensen

    22/04/2015

    1 item of Media coverage

    Press/Media: Press / Media

    Virus viser vej til modgift mod slangebid

    Peter Kristensen

    12/08/202017/08/2020

    10 items of Media coverage

    Press/Media: Press / Media

    Nordjysk virus-forsker: Derfor skal du ikke være nervøs for corona

    Peter Kristensen

    27/02/2020

    1 item of Media coverage

    Press/Media: Press / Media