Projects per year
Personal profile
Research profile
The research of Peter Kristensen is centered on the technical development and application of methods that allow Darwinian evolution of proteins using directed evolution technologies.
The main scientific contributions have more specifically been in the area of recombinant antibodies and methods of isolating such antibodies from large libraries. In addition Peter Kristensen was the first to develop technologies which allow isolation of proteins with improved stabilities from large libraries of mutants. The interest to make technological developments based on recombinant antibodies and for manipulating protein stability and activity, were initiated while Peter Kristensen performed his post doc at the MRC-LMB in Cambridge in the group of Nobel Laureate Sir Greg Winter. However to justify technological development, the technology developed should be able to provide new insight or solve important problems and here we have especially focused attention at finding novel biomarkers which can be used in characterization of important human conditions, such as age related diseases and rare circulating cells in the blood, just to mention the most relevant example. Most recently, the research has involved the use of non-natural amino acids for immobilization and conjugation of recombinant antibodies and proteins of industrial interest and novel biosensors building on recombinant antibody technology.
PhD Supervision
|
Name |
Title of Thesis |
University of Enrolment |
Year |
Role |
|
Svend Kjær |
Use of phage displayed repertoires in the study of eukaryotic elongation factor 1A |
Aarhus University |
1998 |
Project Supervisor |
|
Henrik Sølvsten |
Detection and Regulation of the Vitamin D Receptor |
Aarhus University (Faculty of Health) |
1998 |
Co-Supervisor |
|
Troels Wind |
Phage Display as a tool for elucidation of Ras biology |
Aarhus University |
1999 |
Project Supervisor |
|
Brian Stausbøl-Grøn |
solation and Characterisation of Recombinant Human Antibody Fragments From Phage Display Antibody Libraries |
Aarhus University (Faculty of Health) |
1999 |
Co-Supervisor |
|
Kristian Hobolt Jensen |
Application of phage display and understanding of the infection process |
Aarhus University |
2000 |
Project Supervisor |
|
Kim Bak Jensen |
Identification of Keratinocyte Specific Markers Using Phage Display |
Aarhus University |
2002 |
Project Supervisor |
|
Charlotte Georgi Jakobsen |
Establishment of human and murine IgE and IgG combinatorial phage libraries |
Aarhus University |
2003 |
Project Supervisor |
|
Martin Larsen |
Studies on immune presenting systems with potential of improving vaccines |
Aarhus University |
2004 |
Project Supervisor |
|
Potjamas Pansri |
Production of Antibody by phage display technology |
Suranaree University of Technology, Thailand |
2008 |
Co-Supervisor |
|
Lu Sang |
Phage antibody Technology Applied to Identify New Molecular Targets on LM-332 Positive Malignant Cells |
Aarhus University |
2008 |
Project Supervisor |
|
Louise Boisen |
Using phage display to investigate age-related changes in the proteome and their influence on angiogenesis |
Aarhus University |
2009 |
Project Supervisor |
|
Morten Dræby Sørensen |
Selection of antibodies by phage display against rare circulating cells in the peripheral bloodstream |
Aarhus Univesity |
2010 |
Supervisor |
|
Ole Aalund Mandrup |
Phage Display Libraries, Selections and Screenings for the Identification of Internalizing Antibodies and Cellular Markers |
Aarhus University |
2012 |
Supervisor |
|
Theresa Meldgaard |
Discovery of Cell Specific Biomarkers in Breast Cancer using Recombinant Antibodies |
Aarhus University |
2013 (2014 due to maternatiy leave |
Supervisor |
|
Lotte Rasmussen |
Tracing vasculogenesis in tumours – with special emphasis on characterisation and involvement of endothelial outgrowth cells |
Aarhus University |
2014 |
Co-supervisor |
|
Simon Asbjørn Larsen |
Identification and Analysis of Cell-specific Biomarkers of Breast Cancer Subpopulations by Recombinant antibody selection |
Aarhus University |
2014 |
Supervisor |
|
Jesper Just |
Exploration of the Pericyte and Oxidative Stress by Recombinant Antibody Technology |
Aarhus University |
2015 |
Supervisor |
|
Niels Anton Friis |
|
Aarhus University |
2014 |
Supervisor |
|
SimonLykkemark |
A Novel Phage Display Selection Method for Pericyte Marker Discovery |
Aarhus University |
2016 |
Supervisor |
|
Mathias Lindh Jørgensen |
Identification and Exploration of Biomarkers associated to circulating tumour cells by recombinant antibody technology |
Aarhus Universitet |
2017 |
Supervisor |
|
Emil Frank Holmquist |
Organic Reaction-Based Capture ELISA: Development of High-Throughput Screening Assays for Acetoacetate and Methylglyoxal |
Aarhus University |
2016 |
Co-supervisor |
|
Rasmus Kold-Christensen |
|
|
2019 |
Co-supervisor |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Chemistry and Biotechnology, PhD, Aarhus University
1992 → 2 Oct 1995
Award Date: 2 Oct 1995
Chemistry and Biotechnology, MSc, Aarhus University
1 Sept 1986 → 30 Jun 1992
Award Date: 1 Jun 1992
External positions
Associate Professor (MSK), Department of Engineering, Aarhus University, Gustav Wieds Vej 10C, Aarhus C, DK-8000, Denmark.
2010 → 2017
Associate Professor (MSK), Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10, Aarhus, Denmark.
2003 → 2010
Senior Scientist, Aarhus Universityhospital, Denmark
2001 → 2002
Research Associate Professor, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10, Aarhus, Denmark.
2000 → 2001
Research Assistant Professor, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10, Aarhus, Denmark.
1998 → 2000
Research Scientist, Medical Research Council Centre, Laboratory for Molecular Biology (MRC-LMB)
1997 → 1998
Post-doctoral Fellow, Medical Research Council Centre, Laboratory for Molecular Biology (MRC-LMB)
1995 → 1997
Keywords
- Chemistry and Bioscience
- Protein Science
- protein engineering
- aging
- biomarkers
- antibody engineering
- phage display
- cancer stem cells
- Biomedicine
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Collaborations from the last five years
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Projects
- 1 Active
-
FIFA: Fungal Infections Fought by Fungal antibodies
Kristensen, P., Søndergaard, T. & Heinis, C.
01/08/2024 → 31/07/2027
Project: Research
-
An anti vimentin antibody promotes tube formation
Jørgensen, M. L., Møller, C. K., Rasmussen, L., Boisen, L., Pedersen, H. & Kristensen, P., 15 Jun 2017, In: Scientific Reports. 7, 1, 3576.Research output: Contribution to journal › Journal article › Research › peer-review
8 Citations (Scopus) -
Pericyte modulation by a functional antibody obtained by a novel single-cell selection strategy
Just, J., Lykkemark, S., Nielsen, C. H., Roshenas, A. R., Drasbek, K. R., Petersen, S. V., Bek, T. & Kristensen, P., 1 Aug 2017, In: Microcirculation. 24, 6, e12365.Research output: Contribution to journal › Journal article › Research › peer-review
3 Citations (Scopus) -
A novel excision selection method for isolation of antibodies binding antigens expressed specifically by rare cells in tissue sections
Lykkemark, S., Mandrup, O. A., Jensen, M. B., Just, J. & Kristensen, P., 1 Jun 2017, In: Nucleic Acids Research. 45, 11, p. e107Research output: Contribution to journal › Journal article › Research › peer-review
5 Citations (Scopus) -
Identification of an unstable 4-hydroxynoneal modification on the 20S proteasome subunit α7 by recombinant antibody technology.
Just, J., Jung, T., Friis, N. A., Lykkemark, S., Drasbek, K., Siboska, G., Grune, T. & Kristensen, P., 1 Dec 2015, In: Free Radical Biology and Medicine. 89, p. 786-792 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
14 Citations (Scopus) -
Deep mining of antibody phage-display selections using Oxford Nanopore Technologies and Dual Unique Molecular Identifiers
Mejias-Gomez, O., Braghetto, M., Sørensen, M. K. D., Madsen, A. V., Guiu, L. S., Kristensen, P., Pedersen, L. E. & Goletz, S., 25 May 2024, In: New Biotechnology. 80, p. 56-68 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access
Activities
-
Selection of peptides against human IgE-Fc using phage display
Kristensen, P. (Internal examiner)
21 Jan 2022Activity: Examination › External examination
-
Discovery of single-domain antibodies against Clostridium difficile
Peter Kristensen (Internal examiner)
20 Jan 2022Activity: Examination › External examination
-
Discovery of single-domain antibodies against two distinct adhesion factors of Clostridium difficile
Peter Kristensen (Internal examiner)
20 Jan 2022Activity: Examination › External examination
-
Partial site-saturation and semi-rational engineering of fatty acid hydratases from Lactobacillus Acidophilus and optimization of bi-enzymatic cascade reaction system towards production of hydroxy fatty acids
Kristensen, P. (Internal examiner)
17 Jan 2022Activity: Examination › External examination
-
Avidity and multivalent target engagement in antibodies
Kristensen, P. (Internal examiner)
17 Jan 2022Activity: Examination › External examination
Press/Media
-
Se video: Her er, hvad du skal vide om coronavirussen
31/01/2020
1 item of Media coverage
Press/Media: Press / Media
-
-
Innovativt dansk forsøg kan bane vejen for bedre slange-modgift
20/06/2022 → 23/06/2022
3 items of Media coverage
Press/Media: Press / Media
-
Virus viser vej til modgift mod slangebid
12/08/2020 → 17/08/2020
10 items of Media coverage
Press/Media: Press / Media
-
Nordjysk virus-forsker: Derfor skal du ikke være nervøs for corona
27/02/2020
1 item of Media coverage
Press/Media: Press / Media
Impacts
-
YKL-40 antibody and uses thereof
Peter Kristensen (Participant), Udo Schumacher (Participant) & Peter Minor (Participant)
Impact: Quality of life impact