Photo of Christian Holt
  • Fredrik Bajers Vej 7, H, 1534

    9220 Aalborg

    Denmark

20172020
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  • 4 Similar Profiles
Calmodulin Medicine & Life Sciences
Mutation Medicine & Life Sciences
Cardiac Arrhythmias Medicine & Life Sciences
Ryanodine Receptor Calcium Release Channel Medicine & Life Sciences
Calcium Channels Medicine & Life Sciences
EF Hand Motifs Medicine & Life Sciences
Proteins Medicine & Life Sciences
Mutant Proteins Medicine & Life Sciences

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Research Output 2017 2020

  • 3 Journal article
  • 1 Ph.D. thesis

Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca2+ binding and cause misfolding

Wang, K., Brohus, M., Holt, C., Overgaard, M. T., Wimmer, R. & Van Petegem, F., 3 Feb 2020, In : The Journal of Physiology.

Research output: Contribution to journalJournal articleResearchpeer-review

Calmodulin
Cardiac Arrhythmias
Mutation
EF Hand Motifs
Proteins
4 Citations (Scopus)

Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel

Wang, K., Holt, C., Lu, J., Brohus, M., Larsen, K. T., Overgaard, M. T., Wimmer, R. & Van Petegem, F., 6 Nov 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 45, p. E10556-E10565 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Calmodulin
Calcium Channels
Cardiac Arrhythmias
Mutation
EF Hand Motifs

Calmodulin Mutations Alter the Structure and Interaction with Cardiac Calcium Channels

Holt, C., 2018, (Ph.d.-serien for Det Ingeniør- og Naturvidenskabelige Fakultet, Aalborg Universitet).

Research output: Book/ReportPh.D. thesisResearch

13 Citations (Scopus)

The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+-binding but not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor

Søndergaard, M. T., Liu, Y., Larsen, K. T., Nani, A., Tian, X., Holt, C., Wang, R., Wimmer, R., Van Petegem, F., Fill, M., Chen, S. R. W. & Overgaard, M. T., Jan 2017, In : Journal of Biological Chemistry. 292, p. 1385-1395 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Ryanodine Receptor Calcium Release Channel
Calmodulin
Mutation

Activities 2018 2018

  • 1 Conference presentations

The F141L mutation in human calmodulin disrupts the structure and leads to misregulation of a voltage-gated cardiac calcium channel

Christian Holt (Other), Malene Bredal Brohus (Other), Kaiqian Wang (Other), Filip Van Petegem (Other), Michael Toft Overgaard (Other), Reinhard Wimmer (Lecturer)
19 Aug 201824 Aug 2018

Activity: Talks and presentationsConference presentations