Photo of Henrik Okkels
  • Denmark

20052020

Research output per year

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Research Output

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Journal article
2020

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Dominguez-Valentin, M., Sampson, J. R., Seppälä, T. T., Ten Broeke, S. W., Plazzer, J-P., Nakken, S., Engel, C., Aretz, S., Jenkins, M. A., Sunde, L., Bernstein, I., Capella, G., Balaguer, F., Thomas, H., Evans, D. G., Burn, J., Greenblatt, M., Hovig, E., de Vos Tot Nederveen Cappel, W. H., Sijmons, R. H. & 68 others, Bertario, L., Tibiletti, M. G., Cavestro, G. M., Lindblom, A., Della Valle, A., Lopez-Köstner, F., Gluck, N., Katz, L. H., Heinimann, K., Vaccaro, C. A., Büttner, R., Görgens, H., Holinski-Feder, E., Morak, M., Holzapfel, S., Hüneburg, R., Knebel Doeberitz, M. V., Loeffler, M., Rahner, N., Schackert, H. K., Steinke-Lange, V., Schmiegel, W., Vangala, D., Pylvänäinen, K., Renkonen-Sinisalo, L., Hopper, J. L., Win, A. K., Haile, R. W., Lindor, N. M., Gallinger, S., Le Marchand, L., Newcomb, P. A., Figueiredo, J. C., Thibodeau, S. N., Wadt, K., Therkildsen, C., Okkels, H., Ketabi, Z., Moreira, L., Sánchez, A., Serra-Burriel, M., Pineda, M., Navarro, M., Blanco, I., Green, K., Lalloo, F., Crosbie, E. J., Hill, J., Denton, O. G., Frayling, I. M., Rødland, E. A., Vasen, H., Mints, M., Neffa, F., Esperon, P., Alvarez, K., Kariv, R., Rosner, G., Pinero, T. A., Gonzalez, M. L., Kalfayan, P., Tjandra, D., Winship, I. M., Macrae, F., Möslein, G., Mecklin, J-P., Nielsen, M. & Møller, P., Jan 2020, In : Genetics in Medicine. 22, 1, p. 15-25 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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35 Citations (Scopus)
17 Downloads (Pure)

New Pathogenic Germline Variants in Very Early Onset and Familial Colorectal Cancer Patients

Djursby, M., Madsen, M. B., Frederiksen, J. H., Berchtold, L. A., Therkildsen, C., Willemoe, G. L., Hasselby, J. P., Wikman, F., Okkels, H., Skytte, A. B., Nilbert, M., Wadt, K., Gerdes, A. M. & van Overeem Hansen, T., 24 Sep 2020, In : Frontiers in Genetics. 11, 16 p., 566266.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
4 Downloads (Pure)
2019

Detection of PMS2 mutations by screening hereditary nonpolyposis colon cancer families from Denmark and Sweden

Okkels, H., Lagerstedt-Robinsson, K., Wikman, F. P., Hansen, T. V. O., Lolas, I., Lindberg, L. J. & Krarup, H. B., 1 Sep 2019, In : Genetic Testing and Molecular Biomarkers. 23, 9, p. 688-695 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

1 Citation (Scopus)
6 Citations (Scopus)
2018

First reported adult patient with TARP syndrome: A case report

Højland, A. T., Lolas, I., Okkels, H., Lautrup, C. K., Diness, B. R., Petersen, M. B. & Nielsen, I. K., Dec 2018, In : American Journal of Medical Genetics. Part A. 176, 12, p. 2915-2918 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
1 Citation (Scopus)
188 Downloads (Pure)
2013

Functional examination of MLH1, MSH2, and MSH6 intronic mutations identified in Danish colorectal cancer patients

Petersen, S. M., Dandanell, M., Rasmussen, L. J., Gerdes, A-M. A., Krogh, L. N., Bernstein, I., Okkels, H., Wikman, F., Nielsen, F. C. & Hansen, T. V. O., 2013, In : B M C Medical Genetics. 14, p. 103 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

16 Citations (Scopus)
2012

MSH6 Mutations are Frequent in Hereditary Nonpolyposis Colorectal Cancer Families With Normal pMSH6 Expression as Detected by Immunohistochemistry

Okkels, H., Larsen, K. L., Thorlacius-Ussing, O., Vyberg, M., Lindebjerg, J., Sunde, L., Bernstein, I. T., Klarskov, L. L., Holck, S. & Krarup, H. B., 2012, In : Applied Immunohistochemistry & Molecular Morphology. 20, p. 470-7 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

15 Citations (Scopus)
2011

Biomedical informatics as support to individual healthcare in hereditary colon cancer: the Danish HNPCC system

Bernstein, I. T., Larsen, K. L., Timshel, S., Brandt, C., Dinesen, B., Fenger, M., Gerdes, A-M. A., Iversen, L. H., Madsen, M. R., Okkels, H., Sunde, L., Rahr, H. B., Wikman, F. P. & Rossing, N., 2011, In : Human Mutation. 32, p. 551-6 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

9 Citations (Scopus)

Challenges in the Identification of MSH6-Associated Colorectal Cancer: Rectal Location, Less Typical Histology, and a Subset With Retained Mismatch Repair Function

Klarskov, L. L., Holck, S., Bernstein, I. T., Okkels, H., Rambech, E., Baldetorp, B. & Nilbert, M., 1 Sep 2011, In : American Journal of Surgical Pathology. 35, p. 1391-9 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

20 Citations (Scopus)
5 Citations (Scopus)
2010

Genetic variants of glutathione S-transferases mu, theta, and pi display no susceptibility to inflammatory bowel disease in the Danish population

Ernst, A., Andersen, V., Østergaard, M., Jacobsen, B. A., Dagiliene, E., Pedersen, I. S., Drewes, A. M., Okkels, H. & Krarup, H. B., 2010, In : Scandinavian Journal of Gastroenterology. 45, p. 1068-75 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

10 Citations (Scopus)
2009

Functional characterization of rare missense mutations in MLH1 and MSH2 identified in Danish colorectal cancer patients

Christensen, L. L., Kariola, R., Korhonen, M. K., Wikman, F. P., Sunde, L., Gerdes, A-M. A., Okkels, H., Brandt, C., Bernstein, I. T., Hansen, T. V. O., Hagemann-Madsen, R., Andersen, C. L., Nyström, M. & Ørntoft, T. F., 1 Jan 2009, In : Familial Cancer. 8, p. 489-500 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

8 Citations (Scopus)

Major contribution from recurrent alterations and MSH6 mutations in the Danish Lynch syndrome population

Nilbert, M., Wikman, F. P., Hansen, T. V. O., Krarup, H. B., Örntoft, T. F., Nielsen, F. C., Sunde, L., Gerdes, A-M., Cruger, D., Timshel, S., Bisgaard, M-L., Bernstein, I. & Okkels, H., 2009, In : Familial Cancer. 8, p. 75-83 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

28 Citations (Scopus)
2008

Benign course of long-standing hepatitis B virus infection among Greenland Inuit?

Krarup, H. B., Andersen, S., Madsen, P. H., Okkels, H., Hvingel, B. H. & Laurberg, P., 2008, In : Scandinavian Journal of Gastroenterology. 43, 3, p. 334-343 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

34 Citations (Scopus)
2007

Mutations in CARD15 and smoking confer susceptibility to Crohn`s disease in the Danish population

Ernst, A., Jacobsen, B. A., Østergaard, M., Okkels, H., Andersen, V., Dagiliene, E., Pedersen, I. S., Thorsgaard, N., Drewes, A. M. & Krarup, H. B., 2007, In : Scandinavian Journal of Gastroenterology. 42, p. 1445-1451 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

26 Citations (Scopus)
2006
5 Citations (Scopus)
2005

Neurofibromatosis von Recklinghausen Type I Phenotype and Early Onset of Cancers in Siblings Compound Heterozygous for Mutations in MSH6

Østergaard, J. R., Sunde, L. & Okkels, H., 2005, In : American Journal of Medical Genetics. Part A. 139A, p. 96-105

Research output: Contribution to journalJournal articleResearchpeer-review

60 Citations (Scopus)