Projects per year
Personal profile
Research profile
My personal aim is to advance the treatment of inflammatory diseases, focusing on the inflammatory bowel diseases (IBD) and rheumatoid arthritis (RA). The inflammatory diseases remain poorly understood, limiting the development of treatments and diagnostics. Through my research, I aim to bridge this knowledge-gap and identify disease-specific pathways which can serve as biological targets for treatment, while also increasing our fundamental understanding of the diseases.
My primary biological focus is the innate immune system, particularly the development in newborns and the role of neutrophil granulocytes during inflammatory diseases. I perform comprehensive systems biology (OMICS) characterization of clinical samples from patients and cellular assays, using proteomics, combined with advanced microscopy, bioinformatics, and machine learning/AI.
My efforts aim to extract biological insights, to understand the underlying biology of the pathologies, and ultimately translate this to meaningful advances in treatment options and patient care.
Teaching profile
I teach on all academic levels at the university, from 1st semester to PhD level. PBL is a central element in all my teaching activities, and I have attended a number of PBL- andcase-based workshops.
Main subjects:
- Biochemistry
- Eucaryotic cell biology
- Enzyme kinetics
- Bioinformatics
- Proteomics analysis
- Course for case cafilitators
Main methods:
- Lectures with 10-300 students, physical and online with ongoing assignments.
- Project supervision. individual and in groups with laboratory and bioinformatics elements.
- Facilitation of problem-based case learning.
Administrative profile
- Semester coordinator 1st semester, Medicine/MedIS BA.
- Module Coordinator Molecular Biology, Medicine/MedIS BA.
- Union Representative (H-TR) for IDA at AAU SUND
PhD Supervision
- PhD assessment committee chairman (1x2025, 1x 2024, 1x 2023, 2x 2022, 2x 2021)
- Co-supervisor for PhD-students (1x 2024, 1x 2021, 1x 2020)
- Main supervisor for master students (2025, 2x 2024, 2x 2013, 2x 2018)
- Associate Professor assessment committee (chairman 2025)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor Medicinae, Dr. Med (DMSc), Proteomics Characterization of the Innate Immune System, The Faculty of Medicine
Award Date: 5 Jul 2024
Professional postgraduate teacher training, Professional postgraduate teacher training
1 Jan 2017 → 14 Feb 2019
Award Date: 14 Feb 2019
Philosophiae Doctor, PhD, Inflammatory Diseases and proteomics, The Faculty of Engineering and Science
1 Sept 2011 → 31 Aug 2014
Award Date: 23 Dec 2014
Nanotechnology, MS.c., The Faculty of Engineering and Science
1 Sept 2009 → 29 Jun 2011
Award Date: 29 Jun 2011
Nanotechnology, BS.c., The Faculty of Engineering and Science
1 Sept 2006 → 8 Sept 2009
Award Date: 8 Sept 2009
External positions
External consultant, Biogenity
1 Aug 2024 → …
Adjunct Associate Professor in Inflammatory Diseases, University of Southern Denmark
1 Apr 2021 → 31 Mar 2026
Externally Affiliated Postdoctoral Researcher SteenLab Proteomics, Boston Children’s Hospital, Harvard Medical School
1 Apr 2017 → …
Postdoctoral researcher, The innate immune system and inflammation: Proteomics and bioinformatics, Harvard University
1 Oct 2015 → 1 Apr 2017
Postdoctoral resaercher, The innate immune system in inflammatory bowel diseases, Regional Hospital Southern Denmark
1 Apr 2014 → 1 Apr 2015
Keywords
- Biomedicine
- Protein Science
- Systems Biology based approaches using proteomic and metabolomic techniques
- immunology
- innate immune system
- Bioinformatics
- transcriptomics
- proteomics
- Medicine
- Protein Science
- Systems Biology based approaches using proteomic and metabolomic techniques
- immunology
- innate immune system
- Bioinformatics
- transcriptomics
- proteomics
- Chemistry and Bioscience
- biochemistry
- enzymes
- metabolism
- hormones
Fingerprint
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- 1 Similar Profiles
Collaborations from the last five years
Dive into details by clicking on the dots.
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EPIC-HIPC: Systems Biology to Identify Biomarkers of Neonatal Vaccine Immunogenicity (EPIC-HIPC)
Bennike, T. B. (PI)
01/01/2016 → 01/12/2026
Project: Research
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Improved Treatment of Inflammatory Bowel Disease
Bennike, T. B. (PI), Larsen, L. (PI) & Jess, T. (CoI)
01/04/2025 → 01/04/2030
Project: Research
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Molecular biology underlying Mola pregnancies
Bennike, T. B. (PI), Sunde, L. E. M. (PI), Hegtmann, C. L. (PI) & Palmfeldt, J. (PI)
01/12/2024 → 01/12/2028
Project: Research
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Exhaled breath protein composition in patients
Gade, I. L. (PI), Bennike, T. B. (PI), Kristensen, S. R. (PI) & Honoré, B. (PI)
01/02/2024 → …
Project: Research
Research output
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Dynamic molecular changes during the first week of human life follow a robust developmental trajectory
Lee, A. H., Shannon, C. P., Amenyogbe, N., Bennike, T. B., Diray-Arce, J., Idoko, O. T., Gill, E. E., Ben-Othman, R., Pomat, W. S., van Haren, S. D., Cao, K. A. L., Cox, M., Darboe, A., Falsafi, R., Ferrari, D., Harbeson, D. J., He, D., Bing, C., Hinshaw, S. J. & Ndure, J. & 24 others, , 12 Mar 2019, In: Nature Communications. 10, 1, 14 p., 1092.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile143 Citations (Scopus)146 Downloads (Pure) -
Advancing Inflammatory Bowel Disease Treatment by Targeting the Innate Immune System and Precision Drug Delivery
Kiilerich, K. F., Andresen, T., Darbani, B., Gregersen, L. H. K., Liljensøe, A., Bennike, T. B., Holm, R., Moeller, J. B. & Andersen, V., 11 Jan 2025, In: International Journal of Molecular Sciences . 26, 2, 575.Research output: Contribution to journal › Review article › peer-review
Open AccessFile3 Citations (Scopus)19 Downloads (Pure) -
Differences in complement activation of serum-resistant and serum-sensitive Klebsiella pneumoniae isolates
Thomsen, M. E., Bennike, T. B., Christiansen, G., Emmersen, J., Laursen, N. S., Zarantonello, A., Andersen, G. R., Liu, L., Dueholm, M. K. D., Opstrup, K. V., Stensballe, A. & Birkelund, S., Jul 2025, In: Molecular Immunology. 183, p. 274-285 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exhaled breath protein composition in patients hospitalised during the first wave of COVID-19
Gade, I. L., Bodilsen, J., Mariager, T., Hertz, S., Duerlund, L. S. S., Holm, C. K., Madsen, P. H., Bennike, T. B. & Honoré, B., 1 Jul 2025, In: Journal of Breath Research. 19, 3, 036008.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile -
Systemic Changes in Adults With a Fontan Circulation: Insights From the Plasma Proteome
Kelly, B., Ravndal, M., Bach, P., Telinius, N., Bennike, T. B. & Hjortdal, V. E., 20 May 2025, In: Journal of the American Heart Association. 14, 10, e038648.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)2 Downloads (Pure)
Datasets
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Additional file 1 of Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients
Birkelund, S. (Creator), Bennike, T. B. (Creator), Kastaniegaard, K. (Creator), Lausen, M. (Creator), Poulsen, T. B. G. (Creator), Kragstrup, T. W. (Creator), Deleuran, B. W. (Creator), Christiansen, G. (Creator) & Stensballe, A. (Creator), Figshare, 6 Aug 2020
DOI: 10.6084/m9.figshare.12775188.v1, https://springernature.figshare.com/articles/Additional_file_1_of_Proteomic_analysis_of_synovial_fluid_from_rheumatic_arthritis_and_spondyloarthritis_patients/12775188/1 and one more link, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Proteomic_analysis_of_synovial_fluid_from_rheumatic_arthritis_and_spondyloarthritis_patients/12775188 (show fewer)
Dataset
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Complement deposition on Chlamydia trachomatis
Bennike, T. B. (Creator), Nielsen, M. L. (Creator), Thomsen, M. E. (Creator), Christiansen, G. (Creator), Karred, N. (Creator), Stensballe, A. (Creator) & Birkelund, S. (Creator), PRoteomics IDEntifications Database (PRIDE), 26 May 2020
https://www.ebi.ac.uk/pride/archive/projects/PXD019393
Dataset
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Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients
Birkelund, S. (Creator), Bennike, T. B. (Creator), Kastaniegaard, K. (Creator), Lausen, M. (Creator), Poulsen, T. B. G. (Creator), Kragstrup, T. W. (Creator), Deleuran, B. W. (Creator), Christiansen, G. (Creator) & Stensballe, A. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.c.5085102, https://springernature.figshare.com/collections/Proteomic_analysis_of_synovial_fluid_from_rheumatic_arthritis_and_spondyloarthritis_patients/5085102
Dataset
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Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients
Birkelund, S. (Creator), Bennike, T. B. (Creator), Kastaniegaard, K. (Creator), Lausen, M. (Creator), Poulsen, T. B. G. (Creator), Kragstrup, T. W. (Creator), Deleuran, B. W. (Creator), Christiansen, G. (Creator) & Stensballe, A. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.c.5085102.v1, https://doi.org/10.6084%2Fm9.figshare.c.5085102.v1
Dataset
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Depleted Prefractionated Human Plasma for Data Independent Acquisition Spectral Library
Bennike, T. B. (Creator), Bellin, M. D. (Contributor), Xuan, Y. (Contributor), Stensballe, A. (Contributor), Møller, F. T. (Contributor), Beilman, G. (Contributor), Levy, O. (Contributor), Cruz-Monserrate, Z. (Contributor), Andersen, V. (Contributor), Steen, J. (Contributor), Conwell, D. L. (Contributor) & Steen, H. (Contributor), PRoteomics IDEntifications Database (PRIDE), 18 Apr 2018
https://www.ebi.ac.uk/pride/archive/projects/PXD008163
Dataset
Prizes
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Svend Andersen Foundation's Research Talent Award
Bennike, T. B. (Recipient), 2025
Prize: Research, education and innovation prizes
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Teacher of the Year at The Faculty of Medicine
Bennike, T. B. (Recipient), 2025
Prize: Educational prizes
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Teacher of the Year at The Studyboard for Medicine
Bennike, T. B. (Recipient), 2025
Prize: Educational prizes
Activities
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Ontogeny of the plasma proteome across the first week of human life
Bennike, T. B. (Lecturer)
18 Oct 2019Activity: Talks and presentations › Conference presentations
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Boston Children's Hospital
Bennike, T. B. (Visiting researcher)
26 Feb 2025 → 3 Mar 2025Activity: Visiting another research institution
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US Human Proteome Organization Conference 2025
Bennike, T. B. (Organizer)
25 Feb 2025Activity: Attending an event › Conference organisation or participation
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OA07.03 | Insights from 3000 plasma proteins into the underlying biology of living with a Fontan Circulation and resulting Symptoms
Bennike, T. B. (Lecturer)
25 Feb 2025Activity: Talks and presentations › Conference presentations
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Aalborg R user meeting
Bennike, T. B. (Organizer) & Brøndum, R. F. (Organizer)
22 Jan 2025Activity: Attending an event › Organisation or participation in workshops, courses, seminars, exhibitions or similar
Press/Media
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Bedre børnevaccination med Big Data: Ny forskning kortlægger nyfødtes komplicerede første uge
14/03/2019 → 14/03/2019
4 items of Media coverage
Press/Media: Press / Media
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How Do Our Immune Systems Develop in the First Days of Life?
22/10/2020
6 items of Media coverage
Press/Media: Press / Media
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Weekly highlight from Precision Vaccines Program
05/07/2019
1 item of Media coverage
Press/Media: Press / Media
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Big data er vejen til bedre børnevaccinationer
03/04/2019
1 item of Media coverage
Press/Media: Press / Media
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Small babies, big data - Systems biology reveals babies' detailed developmental trajectory during week 1 of life
12/03/2019
1 item of Media coverage
Press/Media: Press / Media