Tue Bjerg Bennike

2025

Advancing Inflammatory Bowel Disease Treatment by Targeting the Innate Immune System and Precision Drug Delivery

Kiilerich, K. F., Andresen, T., Darbani, B., Gregersen, L. H. K., Liljensøe, A., Bennike, T. B., Holm, R., Moeller, J. B. & Andersen, V., 11 Jan 2025, In: International Journal of Molecular Sciences . 26, 2, 575.

Research output: Contribution to journal › Review article › peer-review

Open Access

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3 Citations (Scopus)

21 Downloads (Pure)

Differences in complement activation of serum-resistant and serum-sensitive Klebsiella pneumoniae isolates

Thomsen, M. E., Bennike, T. B., Christiansen, G., Emmersen, J., Laursen, N. S., Zarantonello, A., Andersen, G. R., Liu, L., Dueholm, M. K. D., Opstrup, K. V., Stensballe, A. & Birkelund, S., Jul 2025, In: Molecular Immunology. 183, p. 274-285 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exhaled breath protein composition in patients hospitalised during the first wave of COVID-19

Gade, I. L., Bodilsen, J., Mariager, T., Hertz, S., Duerlund, L. S. S., Holm, C. K., Madsen, P. H., Bennike, T. B. & Honoré, B., 1 Jul 2025, In: Journal of Breath Research. 19, 3, 036008.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

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Systemic Changes in Adults With a Fontan Circulation: Insights From the Plasma Proteome

Kelly, B., Ravndal, M., Bach, P., Telinius, N., Bennike, T. B. & Hjortdal, V. E., 20 May 2025, In: Journal of the American Heart Association. 14, 10, e038648.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

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1 Citation (Scopus)

6 Downloads (Pure)

2024

A clinical proteomics study of exhaled breath condensate and biomarkers for pulmonary embolism

Gade, I. L., Juul Riddersholm, S., Stilling-Vinther, T., Brøndum, R. F., Bennike, T. B. & Honoré, B., Jan 2024, In: Journal of Breath Research. 18, 1, 016007.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

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4 Citations (Scopus)

106 Downloads (Pure)

Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation

An, A. Y., Acton, E., Idoko, O. T., Shannon, C. P., Blimkie, T. M., Falsafi, R., Wariri, O., Imam, A., Dibbasey, T., Bennike, T. B., Smolen, K. K., Diray-Arce, J., Ben-Othman, R., Montante, S., Angelidou, A., Odumade, O. A., Martino, D., Tebbutt, S. J., Levy, O. & Steen, H. & 5 others, Kollmann, T. R., Kampmann, B., Hancock, R. E. W., Lee, A. H. & EPIC Consortium, Dec 2024, In: EBioMedicine. 110, 105411.

Research output: Contribution to journal › Journal article › Research › peer-review

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2 Citations (Scopus)

13 Downloads (Pure)

Systemic Changes in Adults Living with a Fontan Circulation – Insights from 3000 plasma proteins

Bennike, T. B., Kelly, B., Ravndal, M., Bach, P., Telinius, N. & Hjortdal, V. E., 24 Oct 2024, p. 1163.

Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review

Open Access

Systemic Changes in Adults Living with a Fontan Circulation - Insights from the plasma proteome

Bennike, T. B., Kelly, B., Ravndal, M., Bach, P., Telinius, N. & Hjortdal, V. E., 3 Dec 2024.

Research output: Contribution to conference without publisher/journal › Poster › Communication

2023

Advances in proteomics: characterization of the innate immune system after birth and during inflammation

Bennike, T. B., 6 Oct 2023, In: Frontiers in Immunology. 14, 1254948.

Research output: Contribution to journal › Review article › peer-review

Open Access

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8 Citations (Scopus)

61 Downloads (Pure)

Complement killing of clinical Klebsiella pneumoniae isolates is serum concentration dependent

Opstrup, K. V., Bennike, T. B., Christiansen, G. & Birkelund, S., May 2023, In: Microbes and Infection. 25, 4, 105074.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Impaired Abcb1a function and red meat in a translational colitis mouse model induces inflammation and alters microbiota composition

Stensballe, A., Bennike, T. B., Ravn-Haren, G., Mortensen, A., Aboo, C., Knudsen, L. A., Rühlemann, M. C., Birkelund, S., Bang, C., Franke, A., Vogel, U., Hansen, A. K. & Andersen, V., 31 Jul 2023, In: Frontiers in Medicine. 10, 1200317.

Research output: Contribution to journal › Journal article › Research › peer-review

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3 Citations (Scopus)

58 Downloads (Pure)

Investigating the Crime Scene-Molecular Signatures in Inflammatory Bowel Disease

Andersen, V., Bennike, T. B., Bang, C., Rioux, J. D., Hébert-Milette, I., Sato, T., Hansen, A. K. & Nielsen, O. H., 7 Jul 2023, In: International Journal of Molecular Sciences . 24, 13, 11217.

Research output: Contribution to journal › Review article › peer-review

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7 Citations (Scopus)

111 Downloads (Pure)

2022

Molecular insights into patent ductus arteriosus in extremely preterm neonates: More than a hemodynamic challenge

Bennike, T. B., Sellmer, A., Henriksen, T. B., Palmfeldt, J., Bech, B. H., Astono, J. & Hjortdal, V. E., 6 Dec 2022.

Research output: Contribution to conference without publisher/journal › Poster › Research

New insights into the ulcerative colitis etiology from multi-OMICS integration analysis of the colon mucosa proteome and transcriptome

Bennike, T. B., Christiansen, G., Birkelund, S. & Andersen, V., 29 Aug 2022.

Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review

The Patent Ductus Arteriosus in Extremely Preterm Neonates Is More than a Hemodynamic Challenge: New Molecular Insights

Sellmer, A., Henriksen, T. B., Palmfeldt, J., Bech, B. H., Astono, J., Bennike, T. B. & Hjortdal, V. E., 25 Aug 2022, In: Biomolecules. 12, 9, 1179.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

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4 Citations (Scopus)

80 Downloads (Pure)

Urine Proteomics Reveals Sex-Specific Response to Total Pancreatectomy with Islet Autotransplantation

Bennike, T. B., Templeton, K., Fujimura, K., Bellin, M. D., Ahmed, S., Schlaffner, C. N., Arora, R., Cruz-Monserrate, Z., Arnaout, R., Beilman, G. J., Groverc, A. S., Conwell, D. L. & Steen, H., May 2022, In: Pancreas. 51, 5, p. 435-444 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

1 Citation (Scopus)

2021

Analysis of complement deposition and processing on Chlamydia trachomatis

Lausen, M., Thomsen, M. E., Christiansen, G., Karred, N., Stensballe, A., Bennike, T. B. & Birkelund, S., Feb 2021, In: Medical Microbiology and Immunology. 210, 1, p. 13-32 20 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Hour-of-life Matters: The Plasma Proteome of Healthy Newborns

EPIC/HIPC Consortium, 18 Nov 2021.

Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review

Sample Preparation for High-Throughput Urine Proteomics Using 96-Well Polyvinylidene Fluoride (PVDF) Membranes

Ahmed, S., Fatou, B., Mehta, N. M., Bennike, T. B. & Steen, H., 2021, Translational Urinomics. Springer, p. 1-12 12 p. (Advances in Experimental Medicine and Biology, Vol. 1306).

Research output: Contribution to book/anthology/report/conference proceeding › Book chapter › Research › peer-review

2 Citations (Scopus)

2020

Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life

Bennike, T. B., Fatou, B., Angelidou, A., Diray-Arce, J., Falsafi, R., Ford, R., Gill, E. E., van Haren, S. D., Idoko, O. T., Lee, A. H., Ben-Othman, R., Pomat, W. S., Shannon, C. P., Smolen, K. K., Tebbutt, S. J., Ozonoff, A., Richmond, P. C., Biggelaar, A. H. J. V. D., Hancock, R. E. W. & Kampmann, B. & 3 others, Kollmann, T. R., Levy, O. & Steen, H., 20 Oct 2020, In: Frontiers in Immunology. 11, 578505.

Research output: Contribution to journal › Journal article › Research › peer-review

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25 Citations (Scopus)

172 Downloads (Pure)

Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients

Birkelund, S., Bennike, T. B., Kastaniegaard, K., Lausen, M., Poulsen, T. B. G., Kragstrup, T. W., Deleuran, B. W., Christiansen, G. & Stensballe, A., 2020, In: Clinical proteomics. 17, 1, 29.

Research output: Contribution to journal › Journal article › Research › peer-review

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34 Citations (Scopus)

157 Downloads (Pure)

2019

Data from quantitative serum proteomic analysis after laparoscopic gastric plication

Savedoroudi, P., Bennike, T. B., Kastaniegaard, K., Talebpour, M., Ghassempour, A. & Stensballe, A., 1 Aug 2019, In: Data in Brief. 25, 8 p., 104077.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

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2 Citations (Scopus)

1381 Downloads (Pure)

Degradation of the extracellular matrix is part of the pathology of ulcerative colitis

Kirov, S., Sasson, A., Zhang, C., Chasalow, S., Dongre, A., Steen, H., Stensballe, A., Andersen, V., Birkelund, S. & Bennike, T. B., 31 Jan 2019, In: Molecular Omics. 15, 1, p. 67-76 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

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23 Citations (Scopus)

163 Downloads (Pure)

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

Lee, A. H., Shannon, C. P., Amenyogbe, N., Bennike, T. B., Diray-Arce, J., Idoko, O. T., Gill, E. E., Ben-Othman, R., Pomat, W. S., van Haren, S. D., Cao, K. A. L., Cox, M., Darboe, A., Falsafi, R., Ferrari, D., Harbeson, D. J., He, D., Bing, C., Hinshaw, S. J. & Ndure, J. & 24 others, Njie-Jobe, J., Pettengill, M. A., Richmond, P. C., Ford, R., Saleu, G., Masiria, G., Matlam, J. P., Kirarock, W., Roberts, E., Malek, M., Sanchez-Schmitz, G., Singh, A., Angelidou, A., Smolen, K. K., The EPIC Consortium, Brinkman, R. R., Ozonoff, A., Hancock, R. E. W., van den Biggelaar, A. H. J., Steen, H., Tebbutt, S. J., Kampmann, B., Levy, O. & Kollmann, T. R., 12 Mar 2019, In: Nature Communications. 10, 1, 14 p., 1092.

Research output: Contribution to journal › Journal article › Research › peer-review

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143 Citations (Scopus)

148 Downloads (Pure)

Ontogeny of the plasma proteome during the first week of life

Bennike, T. B., Fatou, B., Wurie, Z., Idoko, O. T., Kampmann, B., Levy, O. & Steen, H., 27 Mar 2019.

Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review

Phenotyping of multiple biofluids for liquid biomarkers for diagnostics and personalized medicine

Poulsen, T. B. G., Bennike, T. B., Birkelund, S., Nielsen, C. H., Sangild, P. T., Rasmussen, S., Arendt-Nielsen, L. & Stensballe, A., 2019.

Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research › peer-review

Serum proteome changes and accelerated reduction of fat mass after laparoscopic gastric plication in morbidly obese patients

Savedoroudi, P., Bennike, T. B., Kastaniegaard, K., Talebpour, M., Ghassempour, A. & Stensballe, A., 15 Jul 2019, In: Journal of Proteomics. 203, 103373.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

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4 Citations (Scopus)

135 Downloads (Pure)

2018

A Cost-Effective High-Throughput Plasma and Serum Proteomics Workflow Enables Mapping of the Molecular Impact of Total Pancreatectomy with Islet Autotransplantation

Bennike, T. B., Bellin, M. D., Xuan, Y., Stensballe, A., Møller, F. T., Beilman, G. J., Levy, O., Cruz-Monserrate, Z., Andersen, V., Steen, J., Conwell, D. L. & Steen, H., 19 Apr 2018, In: Journal of Proteome Research. 17, 5, p. 1983-1992 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

35 Citations (Scopus)

Clinical proteomics - Advances in proteomics and protein arrays for personalized and precision medicine

Poulsen, T. B. G., Meyer, M. K., Kastaniegaard, K., Bastrup, J., Bennike, T. B. & Stensballe, A., 15 May 2018, Systems Biology of Synovialis from Rheumatoid Arthritis and Osteoarthritis Patients Reveals Site-Specific Pathology.

Research output: Contribution to book/anthology/report/conference proceeding › Conference abstract in proceeding › Research

Degradation of the extracellular matrix is part of the pathology of ulcerative colitis

Kirov, S., Sasson, A., Zhang, C., Chasalow, S., Dongre, A., Steen, H., Stensballe, A., Andersen, V., Birkelund, S. & Bennike, T. B., 10 Sept 2018, bioRxiv.

Research output: Working paper/Preprint › Preprint

Open Access

Developing a Serum Proteomics Pipeline for the Mapping of TPIAT-induced Changes to the Serum Proteome

Bellin, M., Bennike, T. B., Ahmed, S., Cruz-Monserrate, Z., Beilman, G., Conwell, D. & Steen, H., 31 Oct 2018, p. P1-64.

Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review

Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases: protocol for a prospective cohort study of prognostic factors and personalised medicine

Christensen, R., Heitmann, B. L., Andersen, K. W., Nielsen, O. H., Sørensen, S. B., Jawhara, M., Bygum, A., Hvid, L., Grauslund, J., Wied, J., Glerup, H., Fredberg, U., Villadsen, J. A., Kjær, S. G., Fallingborg, J., Moghadd, S. A. G. R., Knudsen, T., Brodersen, J., Frøjk, J. & Dahlerup, J. F. & 21 others, Bojesen, A. B., Sorensen, G. L., Thiel, S., Færgeman, N. J., Brandslund, I., Bennike, T. B., Stensballe, A., Schmidt, E. B., Franke, A., Ellinghaus, D., Rosenstiel, P., Raes, J., Boye, M., Werner, L., Nielsen, C. L., Munk, H. L., Nexøe, A. B., Ellingsen, T., Holmskov, U., Kjeldsen, J. & Andersen, V., 1 Feb 2018, In: BMJ Open. 8, 2, 15 p., e018166.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

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22 Citations (Scopus)

302 Downloads (Pure)

Investigating the Urinary Proteome pre and post Total Pancreatectomy with Islet Autotransplantation(TPIAT)

Bellin, M., Bennike, T. B., Ahmed, S., Cruz-Monserrate, Z., Arora, R., Beilman, G., Arnaout, R., Conwell, D. & Steen, H., 31 Oct 2018, p. P1-65.

Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review

Taking a first Peek at the Ontogeny of the Plasma Proteome during the first week of life

Bennike, T. B., 29 Jan 2018.

Research output: Contribution to conference without publisher/journal › Poster › Research

2017

High-throughput parallel proteomic sample preparation using 96-well polyvinylidene fluoride (PVDF) membranes and C18 purification plates

Bennike, T. B. & Steen, H., 2017, Serum/Plasma Proteomics: Methods and Protocols. Greening, D. W. & Simpson, R. J. (eds.). 2 ed. Humana Press, p. 395-402 (Methods in Molecular Biology; No. 1619).

Research output: Contribution to book/anthology/report/conference proceeding › Book chapter › Research › peer-review

14 Citations (Scopus)

Proteome analysis of rheumatoid arthritis gut mucosa

Bennike, T. B., Ellingsen, T., Glerup, H., Bonderup, O. K., Carlsen, T. G., Meyer, M. K., Bøgsted, M., Christiansen, G., Birkelund, S., Andersen, V. & Stensballe, A., 2017, In: Journal of Proteome Research. 16, 1, p. 346-354

Research output: Contribution to journal › Journal article › Research › peer-review

55 Citations (Scopus)

Proteomics dataset: The colon mucosa from inflammatory bowel disease patients, gastrointestinal asymptomic rheumatoid arthritis patients, and controls

Bennike, T. B., Carlsen, T. G., Ellingsen, T., Bonderup, O. K., Glerup, H., Bøgsted, M., Christiansen, G., Birkelund, S., Andersen, V. & Stensballe, A., Dec 2017, In: Data in Brief. 15, p. 511-516 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

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4 Citations (Scopus)

389 Downloads (Pure)

The colon mucosa is a potential site for the initial triggering of Rheumatoid Arthritis: A study of proteins reveals that the colon mucosa is a potential site of immune tolerance break towards proteins with the post-translational modification citrullination, which could contribute to the onset of the joint disease rheumatoid arthritis

Bennike, T. B., Ellingsen, T. J., Glerup, H., Bonderup, O. K., Carlsen, T. G., Meyer, M. K., Bøgsted, M., Christiansen, G., Birkelund, S., Andersen, V. & Stensballe, A., Jun 2017, In: Biomedical Advances.

Research output: Contribution to journal › Journal article › Communication

Open Access

2016

Assessing the Role of Citrullination and Lipid Interaction with Myelin Basic Protein in Multiple Sclerosis Etiology

Kastaniegaard, K., Bennike, T. B., Nielsen, S., Stensballe, A. & Nieland, J. D., 2 Jun 2016.

Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research › peer-review

Open Access

Comparing the proteome of snap frozen, RNAlater preserved, and formalin-fixed paraffin-embedded human tissue samples

Bennike, T. B., Kastaniegaard, K., Padurariu, S., Gaihede, M., Birkelund, S., Andersen, V. & Stensballe, A., 2016, In: EuPA Open Proteomics. 10, p. 9-18

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

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45 Citations (Scopus)

271 Downloads (Pure)

Proteome stability analysis of snap frozen, RNAlater preserved, and formalin-fixed paraffin-embedded human colon mucosal biopsies

Bennike, T. B., Kastaniegaard, K., Padurariu, S., Gaihede, M., Birkelund, S., Andersen, V. & Stensballe, A., 2016, In: Data in Brief. 6, p. 942-947

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

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19 Citations (Scopus)

490 Downloads (Pure)

Strategies for biological drug quantification in biological drug immune responses

Meyer, M. K., Andersen, M., Stausbo , T. V., Bennike, T. B., Andersen, G. N. & Stensballe, A., 2016.

Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research › peer-review

Open Access

The Pig PeptideAtlas: a resource for systems biology in animal production and biomedicine

Hesselager, M. O., Codrea, M. C., Sun, Z., Deutsch, E. W., Bennike, T. B., Stensballe, A., Bundgaard, L., Moritz, R. L. & Bendixen, E., 2016, In: Proteomics. 16, 4, p. 634-644

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

46 Citations (Scopus)

Therapeutic drug quantification using targeted mass spectrometry

Meyer, M. K., Andersen, M., Stausbo , T. V., Bennike, T. B., Andersen, G. N. & Stensballe, A., 2016.

Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research › peer-review

Open Access

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147 Downloads (Pure)

Time-course investigation of Phytophthora infestans infection of potato leaf from three cultivars by quantitative proteomics

Larsen, M. K. G., Jørgensen, M., Bennike, T. B. & Stensballe, A., 2016, In: Data in Brief. 6, p. 238-248

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

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6 Citations (Scopus)

300 Downloads (Pure)

2015

Characterization of the porcine synovial fluid proteome and a comparison to the plasma proteome

Bennike, T. B., Barnaby, O., Steen, H. & Stensballe, A., 2015, In: Data in Brief. 5, p. 241-247

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

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3 Citations (Scopus)

537 Downloads (Pure)

Effect of IL-6R Inhibition with Tocilizumab on the Proteome of Peripheral Blood Mononuclear Cells from a Rheumatoid Arthritis Patient

Meyer, M. K., Andersen, M., Bennike, T. B., Birkelund, S., Andersen, G. N. & Stensballe, A., 2015, In: Journal of Proteomics & Bioinformatics. 8, 12, p. 274-282

Research output: Contribution to journal › Journal article › Research › peer-review

Open Access

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521 Downloads (Pure)

Inflammatory Diseases – An Analysis of the Underlying Biological Triggers

Bennike, T. B., 2015, Aalborg Universitetsforlag.

Research output: PhD thesis

Open Access

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905 Downloads (Pure)

Neutrophil extracellular traps in ulcerative colitis: a proteome analysis of intestinal biopsies

Bennike, T. B., Carlsen, T. G., Ellingsen, T., Bonderup, O. K., Glerup, H., Bøgsted, M., Christiansen, G., Birkelund, S., Stensballe, A. & Andersen, V., 2015, Congress Abstract Book, 14th Human Proteome Organization World Congress, HUPO2015, 27-30 September 2015, Vancouver, Canada. Human Proteome Organization, p. 25, No. CS07.05

Research output: Contribution to book/anthology/report/conference proceeding › Conference abstract in proceeding › Research › peer-review

Neutrophil extracellular traps in ulcerative colitis: A proteome analysis of intestinal biopsies

Bennike, T. B., Carlsen, T. G., Ellingsen, T., Bonderup, O. K., Glerup, H., Bøgsted, M., Christiansen, G., Birkelund, S., Stensballe, A. & Andersen, V., 2015, Proceedings, Targeted Proteomics Workshop & International Symposium, TPWIS 2015, 10-14 December 2015, Mumbai, India. Indian Institute of Technology, p. 97-98, No. D-1-07

Research output: Contribution to book/anthology/report/conference proceeding › Conference abstract in proceeding › Research › peer-review

Open Access

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Tue Bjerg Bennike

Research output

Search results