Development of cell-free therapy for chronic wound

The use of secretom harvested from electricity-stimulated stem cells for chronic wound

Chronic wounds represent a major health challenge due to the heavy burden on the healthcare system. Chronic non-healing wounds are characterized by non-healed injuries. Factors such as reduced vascularization, persistent inflammation, and ineffectiveness of the immune system can lead to chronic wounds. In order to develop new effective treatments for chronic wounds, there has been an interest for many years in the use of stem cells from adipose tissue, which have been shown to promote healing. Despite their many positive properties, it has been difficult to standardize the isolation, propagation and quality control of the stem cells. However, it has been shown that many of the wound healing properties of stem cells can be attributed to their secretome.
It has previously been shown that electrical stimulation of stem cells can promote their ability to influence vessel formation, reduce inflammation and influence skin tissue regeneration, which collectively contributes to the therapeutic potential of stem cells. In this project, we will investigate whether electrical stimulation of stem cells also increases the therapeutic potential of their secretome in relation to the treatment of chronic wounds.