Project Details
Description
In collaboration with Dr. Poul Henning Jensen, Aarhus University, we are studying the biophysical properties of proteins involved in Parkinson?s Disease. The N-terminal segment of parkin behaves in many ways like its structural homologue ubiquitin, while p25 appears to be partially unfolded under physiological conditions; it is protease-sensitive but undergoes cooperative unfolding. The effects of these proteins on fibrillation of a-synuclein, the causative agent of Parkinson?s Disease, are being investigated using the techniques developed for glucagons. (Jesper S. Pedersen, Jakob Pedersen, Daniel Otzen).
Status | Finished |
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Effective start/end date | 19/05/2010 → 17/04/2018 |