Activities per year
Project Details
Description
-Development of the innate immune system in the newborn.
-Neutrophil granulocytes and neutrophil extracellular traps in inflammatory diseases, including inflammatory bowel disease.
-Role of complement system in sepsis.
-Neutrophil granulocytes and neutrophil extracellular traps in inflammatory diseases, including inflammatory bowel disease.
-Role of complement system in sepsis.
Key findings
-Immune system develops consistently only hours after birth.
-The classical complement activation pathway and membrane attach complex (MAC, or terminal complement complex TCC) are prioritized and may be central for newborn immune protection to pathogens.
-Neutrophil extracellular traps are invovled in the ulcerative colitis (UC) inflammatory bowel disease (IBD) etiology.
-Sepsis may be connected to evading complement system activation.
-The classical complement activation pathway and membrane attach complex (MAC, or terminal complement complex TCC) are prioritized and may be central for newborn immune protection to pathogens.
-Neutrophil extracellular traps are invovled in the ulcerative colitis (UC) inflammatory bowel disease (IBD) etiology.
-Sepsis may be connected to evading complement system activation.
| Status | Active |
|---|---|
| Effective start/end date | 01/01/2014 → … |
Funding
- Carlsbergfondet: DKK350,000.00
- Lundbeck Foundation: DKK700,000.00
- A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal: DKK50,000.00
Keywords
- innate
- immune
- system
- baby
- newborn
- development
- immunity
- inflammatory
- diseases
- IBD
- bowel
- ulcerative colitis
- crohns disease
- UC
- CD
- complement
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
Activities
- 2 Conference presentations
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Large scale proteomics of biofluids
Tue Bjerg Bennike (Lecturer)
5 Dec 2023Activity: Talks and presentations › Conference presentations
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Autoimmune diseases and breach of immune tolerance
Tue Bjerg Bennike (Lecturer)
3 Feb 2022Activity: Talks and presentations › Conference presentations
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Molecular insights into patent ductus arteriosus in extremely preterm neonates: More than a hemodynamic challenge
Bennike, T. B., Sellmer, A., Henriksen, T. B., Palmfeldt, J., Bech, B. H., Astono, J. & Hjortdal, V. E., 6 Dec 2022.Research output: Contribution to conference without publisher/journal › Poster › Research
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New insights into the ulcerative colitis etiology from multi-OMICS integration analysis of the colon mucosa proteome and transcriptome
Bennike, T. B., Christiansen, G., Birkelund, S. & Andersen, V., 29 Aug 2022.Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review
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Urine Proteomics Reveals Sex-Specific Response to Total Pancreatectomy with Islet Autotransplantation
Bennike, T. B., Templeton, K., Fujimura, K., Bellin, M. D., Ahmed, S., Schlaffner, C. N., Arora, R., Cruz-Monserrate, Z., Arnaout, R., Beilman, G. J., Groverc, A. S., Conwell, D. L. & Steen, H., May 2022, In: Pancreas. 51, 5, p. 435-444 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access1 Citation (Scopus)
Press/Media
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How Do Our Immune Systems Develop in the First Days of Life?
22/10/2020
6 items of Media coverage
Press/Media: Press / Media
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Bedre børnevaccination med Big Data: Ny forskning kortlægger nyfødtes komplicerede første uge
14/03/2019 → 14/03/2019
4 items of Media coverage
Press/Media: Press / Media
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Small babies, big data - Systems biology reveals babies' detailed developmental trajectory during week 1 of life
12/03/2019
1 item of Media coverage
Press/Media: Press / Media
Datasets
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Complement deposition on Chlamydia trachomatis
Bennike, T. B. (Creator), Nielsen, M. L. (Creator), Thomsen, M. E. (Creator), Christiansen, G. (Creator), Karred, N. (Creator), Stensballe, A. (Creator) & Birkelund, S. (Creator), PRoteomics IDEntifications Database (PRIDE), 26 May 2020
https://www.ebi.ac.uk/pride/archive/projects/PXD019393
Dataset
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Depleted Prefractionated Human Plasma for Data Independent Acquisition Spectral Library
Bennike, T. B. (Creator), Bellin, M. D. (Contributor), Xuan, Y. (Contributor), Stensballe, A. (Contributor), Møller, F. T. (Contributor), Beilman, G. (Contributor), Levy, O. (Contributor), Cruz-Monserrate, Z. (Contributor), Andersen, V. (Contributor), Steen, J. (Contributor), Conwell, D. L. (Contributor) & Steen, H. (Contributor), PRoteomics IDEntifications Database (PRIDE), 18 Apr 2018
https://www.ebi.ac.uk/pride/archive/projects/PXD008163
Dataset
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A proteome analysis by LC-MS/MS of human colon mucosal biopsies from gastrointestinal healthy rheumatoid arthritis patients
Bennike, T. B. (Creator), Ellingsen, T. (Contributor), Glerup, H. (Contributor), Bonderup, O. K. (Contributor), Carlsen, T. G. (Contributor), Meyer, M. K. (Contributor), Bøgsted, M. (Contributor), Christiansen, G. (Contributor), Birkelund, S. (Contributor), Andersen, V. (Contributor) & Stensballe, A. (Creator), PRoteomics IDEntifications Database (PRIDE), 26 Sept 2016
https://www.ebi.ac.uk/pride/archive/projects/PXD003082
Dataset