Systems Biology to Identify Biomarkers of Neonatal Vaccine Immunogenicity (EPIC-HIPC)

Project Details

Description

Infection is the most common cause of death in early life, especially for newborns and can be reduced by immunization but insufficient knowledge of how vaccines protect the very young limits their optimal use. To gain insight into how vaccines induce protection of the most vulnerable, this National Institutes of Health (NIH)/National Institute of Allergy & Infectious Diseases (NIAID)-funded Human Immunology Project Consortium (HIPC) study, based at Boston Children's Hospital and conducted by the Expanded Program on Immunization Consortium (EPIC), employs two novel approaches studying newborn responses to hepatitis B vaccine (HBV): (a) systems biology that uses technologies which comprehensively measure global changes in molecules such as transcriptomics (RNA) and proteomics (proteins), as well as cell composition of the blood and (b) use of human newborn blood components, collected prior to immunization, to model vaccine responses in vitro (outside the body). Characterizing vaccine-induced molecular patterns ("signatures") that correspond to vaccine-mediated protection will accelerate development and optimization of vaccines against early life infections of major global health importance
(https://clinicaltrials.gov/ct2/show/NCT03246230).

Layman's description

Improve our understanding of our immune system and vaccinations, with a focus on the developing immune system in newborns.
AcronymEPIC-HIPC
StatusActive
Effective start/end date01/01/201601/01/2022

Funding

  • Lundbeck Foundation: DKK18,580.00

Activities

  • 3 Conference presentations
  • 1 Membership of committees, commissions, boards, councils, associations, organisations, or similar

EPIC-HIPC manuscript committee (External organisation)

Tue Bjerg Bennike (Chairman)

1 Apr 2020 → …

Activity: MembershipsMembership of committees, commissions, boards, councils, associations, organisations, or similar

Ontogeny of the plasma proteome across the first week of human life

Tue Bjerg Bennike (Lecturer)

18 Oct 2019

Activity: Talks and presentationsConference presentations

Research Output

Ontogeny of the plasma proteome during the first week of life

Bennike, T. B., Fatou, B., Wurie, Z., Idoko, O. T., Kampmann, B., Levy, O. & Steen, H., 27 Mar 2019.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

  • Press / Media

    Weekly highlight from Precision Vaccines Program

    Tue Bjerg Bennike

    05/07/2019

    1 item of Media coverage

    Press/Media: Press / Media