The innate immune system: Ontogeny and role in inflammatory diseases

Project Details


-Development of the innate immune system in the newborn.
-Neutrophil granulocytes and neutrophil extracellular traps in inflammatory diseases, including inflammatory bowel disease.
-Role of complement system in sepsis.

Key findings

-Immune system develops consistently only hours after birth.
-The classical complement activation pathway and membrane attach complex (MAC, or terminal complement complex TCC) are prioritized and may be central for newborn immune protection to pathogens.
-Neutrophil extracellular traps are invovled in the ulcerative colitis (UC) inflammatory bowel disease (IBD) etiology.
-Sepsis may be connected to evading complement system activation.
Effective start/end date01/01/2014 → …


  • Carlsbergfondet: DKK350,000.00
  • Lundbeck Foundation: DKK700,000.00
  • A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal: DKK50,000.00


  • innate
  • immune
  • system
  • baby
  • newborn
  • development
  • immunity
  • inflammatory
  • diseases
  • IBD
  • bowel
  • ulcerative colitis
  • crohns disease
  • UC
  • CD
  • complement


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