Abstract
6-methylsalicylic acid (6-MSA) is a small, simple polyketide produced by a broad spectrum of fungal species. Since fungi obtained the ability to synthesize 6-MSA from bacteria through a horizontal gene transfer event, it has developed into a multipurpose metabolic hub from where numerous complex compounds are produced. The most relevant metabolite from a human perspective is the small lactone patulin as it is one of the most potent mycotoxins. Other important end products derived from 6-MSA include the small quinone epoxide terreic acid and the prenylated yanuthones. The most advanced modification of 6-MSA is observed in the aculin biosynthetic pathway, which is mediated by a non-ribosomal peptide synthase and a terpene cyclase. In this short review, we summarize for the first time all the possible pathways that takes their onset from 6-MSA and provide a synopsis of the responsible gene clusters and derive the resulting biosynthetic pathways.
Original language | English |
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Article number | lxad107 |
Journal | Journal of Applied Microbiology |
Volume | 134 |
Issue number | 6 |
ISSN | 1364-5072 |
DOIs | |
Publication status | Published - Jun 2023 |
Keywords
- 6-MSA
- 6MSAS
- PKS
- gene clusters
- mycotoxins
- polyketide synthase
- polyketides
- secondary metabolites