68Ga-PSMA PET/CT Uptake in the Ureter Caused by Ligand Expression in Urothelial Cancer

Research output: Contribution to journalJournal articleCommunication

Abstract

Ga-PSMA PET/CT has become a well-established imaging modality to detect prostate cancer (PCa) metastases in biochemical recurrence. Despite its claimed specificity for PCa, Ga-PSMA uptake in tissues unrelated to PCa, particularly in the neovascular tissue of other cancers, has been reported in numerous studies. A 73-year-old man underwent Ga-PSMA PET/CT for biochemical recurrence of PCa 7 years after radical prostatectomy. The Ga-PSMA PET/CT showed 1 lesion with PSMA uptake in the distal left ureter. Histology revealed a low-grade noninvasive papillary urothelial carcinoma. By immunohistochemistry, PSMA expression was observed in the neoplastic urothelial cells and in the vessels of the papillary structures.

Original languageEnglish
JournalClinical Nuclear Medicine
Volume45
Issue number1
Pages (from-to)e43-e45
Number of pages2
ISSN0363-9762
DOIs
Publication statusPublished - Jan 2020

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Ureter
Prostatic Neoplasms
Ligands
Neoplasms
Recurrence
Papillary Carcinoma
Prostatectomy
Histology
Immunohistochemistry
Neoplasm Metastasis

Cite this

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title = "68Ga-PSMA PET/CT Uptake in the Ureter Caused by Ligand Expression in Urothelial Cancer",
abstract = "Ga-PSMA PET/CT has become a well-established imaging modality to detect prostate cancer (PCa) metastases in biochemical recurrence. Despite its claimed specificity for PCa, Ga-PSMA uptake in tissues unrelated to PCa, particularly in the neovascular tissue of other cancers, has been reported in numerous studies. A 73-year-old man underwent Ga-PSMA PET/CT for biochemical recurrence of PCa 7 years after radical prostatectomy. The Ga-PSMA PET/CT showed 1 lesion with PSMA uptake in the distal left ureter. Histology revealed a low-grade noninvasive papillary urothelial carcinoma. By immunohistochemistry, PSMA expression was observed in the neoplastic urothelial cells and in the vessels of the papillary structures.",
author = "Zacho, {Helle D} and Pedersen, {Sine H} and Astrid Petersen and Petersen, {Lars J}",
year = "2020",
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language = "English",
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68Ga-PSMA PET/CT Uptake in the Ureter Caused by Ligand Expression in Urothelial Cancer. / Zacho, Helle D; Pedersen, Sine H; Petersen, Astrid; Petersen, Lars J.

In: Clinical Nuclear Medicine, Vol. 45, No. 1, 01.2020, p. e43-e45.

Research output: Contribution to journalJournal articleCommunication

TY - JOUR

T1 - 68Ga-PSMA PET/CT Uptake in the Ureter Caused by Ligand Expression in Urothelial Cancer

AU - Zacho, Helle D

AU - Pedersen, Sine H

AU - Petersen, Astrid

AU - Petersen, Lars J

PY - 2020/1

Y1 - 2020/1

N2 - Ga-PSMA PET/CT has become a well-established imaging modality to detect prostate cancer (PCa) metastases in biochemical recurrence. Despite its claimed specificity for PCa, Ga-PSMA uptake in tissues unrelated to PCa, particularly in the neovascular tissue of other cancers, has been reported in numerous studies. A 73-year-old man underwent Ga-PSMA PET/CT for biochemical recurrence of PCa 7 years after radical prostatectomy. The Ga-PSMA PET/CT showed 1 lesion with PSMA uptake in the distal left ureter. Histology revealed a low-grade noninvasive papillary urothelial carcinoma. By immunohistochemistry, PSMA expression was observed in the neoplastic urothelial cells and in the vessels of the papillary structures.

AB - Ga-PSMA PET/CT has become a well-established imaging modality to detect prostate cancer (PCa) metastases in biochemical recurrence. Despite its claimed specificity for PCa, Ga-PSMA uptake in tissues unrelated to PCa, particularly in the neovascular tissue of other cancers, has been reported in numerous studies. A 73-year-old man underwent Ga-PSMA PET/CT for biochemical recurrence of PCa 7 years after radical prostatectomy. The Ga-PSMA PET/CT showed 1 lesion with PSMA uptake in the distal left ureter. Histology revealed a low-grade noninvasive papillary urothelial carcinoma. By immunohistochemistry, PSMA expression was observed in the neoplastic urothelial cells and in the vessels of the papillary structures.

U2 - 10.1097/RLU.0000000000002720

DO - 10.1097/RLU.0000000000002720

M3 - Journal article

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SP - e43-e45

JO - Clinical Nuclear Medicine

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SN - 0363-9762

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