Abstract
Background and aims: Approximately 20% of patients with knee osteoarthritis (KOA) experience postoperative pain. Pain in KOA is multifactorial and may include low-grade chronic inflammation. This study aimed 1) to evaluate preoperative serum levels of inflammatory biomarkers in KOA patients compared to healthy controls, 2) investigate preoperative differences of inflammatory biomarkers within different subgroups of patients with KOA and link these subgroups to clinical pain before and after total knee replacement (TKR) surgery.
Methods: Blood samples from preoperative KOA patients (n=200) and healthy participants (n=39) were collected and analyzed using OLINK inflammatory panel. Clinical pain intensity and the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire were assessed before and 12-months after TKR. Multivariate data analysis was performed to identify differences between patients and controls. Hierarchical cluster analysis and orthogonal partial least squares-discriminant analysis (OPLS-DA) was used to identify subgroups within patients with KOA and t-tests were used to evaluate differences in clinical pain intensity and KOOS scores between the groups
Results: Multivariate analysis showed 12 proteins differentially expressed between patients and controls. Hierarchical cluster and OPLS-DA analysis identified two patient subgroups with 23 proteins being significantly (p<0.01) up- or downregulated in the subgroups. Postoperative clinical pain and KOOS were significantly different between patients’ subgroup 1 and subgroup 2 (p<0.05).
Conclusions: This study identified differences in 23 preoperative inflammatory markers comparing patients with KOA and controls. Furthermore, 2 specific subgroups within the patient cohort could be established using 23 inflammatory markers and these subgroups demonstrate different clinical pain and function scores when assessed 12-months after TKR.
| Original language | English |
|---|---|
| Publication date | Sept 2023 |
| Publication status | Published - Sept 2023 |
| Event | 13th Congress of the European Pain Federation EFIC: Personalised Pain Management: The Future is Now - Budapest, Hungary Duration: 20 Sept 2023 → 22 Sept 2023 https://europeanpainfederation.eu/efic2023/ |
Conference
| Conference | 13th Congress of the European Pain Federation EFIC |
|---|---|
| Country/Territory | Hungary |
| City | Budapest |
| Period | 20/09/2023 → 22/09/2023 |
| Internet address |