A novel non-invasive method for measuring knee joint laxity in four dof: In vitro proof-of-concept and validation

Dennis Pedersen, Valentine Vanheule, Roel Wirix-Speetjens, Orçun Taylan , Hendrik Pieter Delport, Lennart Scheys, Michael Skipper Andersen

Research output: Contribution to journalJournal articleResearchpeer-review

5 Citations (Scopus)
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Knee joint laxity or instability is a common problem that may have detrimental consequences for patients. Unfortunately, assessment of knee joint laxity is limited by current methodologies resulting in suboptimal diagnostics and treatment. This paper presents a novel method for accurately measuring non-invasive knee joint laxity in four degrees-of-freedom (DOF). An arthrometer, combining a parallel manipulator and a six-axis force/moment sensor, was developed to be used in combination with a low-dose biplanar x-ray system and 3D image data to reconstruct tibiofemoral position and orientation of laxity measurements. As proof-of-concept, four cadaveric knees were tested in the device. Each cadaveric knee was mounted in the device at approximately 30° of flexion and twelve monoplanar anteroposterior, mediolateral and internal/external load cases were applied. Additionally, four biplanar load cases were applied, consisting of different combinations of anteroposterior and internal/external loads. The arthrometer was limited to four DOF to address the specific measurements. For validation purposes, the pose reconstructions of tibia and femur were compared with pose reconstructions of bone pin marker frames mounted on each bone. The measurements from the arthrometer in terms of translation and rotations displayed comparable values to what have previously been presented in the literature. Furthermore, the measurements revealed coupled motions in multiple planes, demonstrating the importance of multi DOF laxity measurements. The validation displayed an average mean difference for translations of 0.08 mm and an average limit of agreement between −1.64 mm and 1.80 mm. The average mean difference for rotations was 0.10° and the limit of agreement was between −0.85° and 1.05°. The presented method eliminates several limitations present in current methods and may prove a valuable tool for assessing knee joint laxity.

Original languageEnglish
JournalJournal of Biomechanics
Pages (from-to)62-69
Number of pages8
Publication statusPublished - 3 Jan 2019


  • Arthrometry
  • EOS Imaging
  • Laxity
  • Tibiofemoral joint

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