Clinical trials (CTs) are essential for the public and health professionals to trust the treatment options regarding safety and efficacy. However, several studies state that the majority of CTs fail to reach a sufficient sample size, indicating a need to overcome several barriers related to recruitment, for example poor communication and a dysfunctional physician-patient relationship. The use of a tailored information strategy has shown to increase communication and discussion of health-related issues between patients and health professionals. Hence, this study attempted to identify a tailored information strategy for Danish health professionals to increase patient recruitment of a broad Danish audience with different sociodemographic backgrounds. A Danish custom-made questionnaire was developed, distributed via social networking and flyers, and left open for 4 weeks in the fall, 2018. Descriptive statistics were performed to identify a tailored information strategy. Additionally, multinomial regression was performed to investigate associations with respondents’ willingness towards CT participation. In total, 464 questionnaires were included in the analysis. Mainly females (82.11%) and age group 18–34 years (59.70%) answered the questionnaire. Multinomial regression analysis showed that age group 18–34 years, females, having a chronic disease, and participated in a CT in the past, were more willing towards CT participation. A broad agreement was seen among respondents regarding preferable information topics, preferable way to receive information, and preferable health professional. This study found that a tailored information strategy for the Danish population should consist of a dialogue with a physician about CTs’ advantages.