Acid etching and plasma sterilization fail to improve osseointegration of grit blasted titanium implants

Mikkel Saksø Mortensen, Stig Storgaard Jakobsen, Henrik Saksø, Jørgen Baas, Thomas Vestergaard Jakobsen, Kjeld Søballe

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Interaction between implant surface and surrounding bone influences implant fixation. We attempted to improve the bone-implant interaction by 1) adding surface micro scale topography by acid etching, and 2) removing surface-adherent pro-inflammatory agents by plasma cleaning. Implant fixation was evaluated by implant osseointegration and biomechanical fixation.The study consisted of two paired animal sub-studies where 10 skeletally mature Labrador dogs were used. Grit blasted titanium alloy implants were inserted press fit in each proximal tibia. In the first study grit blasted implants were compared with acid etched grit blasted implants. In the second study grit blasted implants were compared with acid etched grit blasted implants that were further treated with plasma sterilization. Implant performance was evaluated by histomorphometrical investigation (tissue-to-implant contact, peri-implant tissue density) and mechanical push-out testing after four weeks observation time.Neither acid etching nor plasma sterilization of the grit blasted implants enhanced osseointegration or mechanical fixation in this press-fit canine implant model in a statistically significant manner.
Original languageEnglish
JournalThe Open Orthopaedics Journal
Volume6
Pages (from-to)376-82
Number of pages7
ISSN1874-3250
DOIs
Publication statusPublished - 2012
Externally publishedYes

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