Acid-induced experimental knee pain and hyperalgesia in healthy humans

Research output: Contribution to journalJournal articleResearchpeer-review

5 Citations (Scopus)

Abstract

Inflammation and the related acidity in peri-articular structures may be involved in pain generation and hyperalgesia in knee osteoarthritis. This study investigated pain and associated hyperalgesia provoked by infusion of acidic saline into the infrapatellar fat pad. Twenty-eight subjects participated in two sessions in which acidic saline (AS, pH 5) or neutral saline (NS, pH 7.4) were infused into the infrapatellar fat pad for 15 min. Pain intensity, pain area, mechanical and thermal sensitivity, and maximal voluntary knee extension force were recorded. Repeated infusions were performed in 14 subjects. Infusion of AS caused significantly higher pain intensity, larger pain areas, induced hyperalgesia around the infused knee, and reduced extension force. No significant pain facilitation or spreading of hyperalgesia was found after repeated infusions as compared with single infusions. Acidic saline infused into the infrapatellar fat pad provoked pain and localized mechanical hyperalgesia. Thus, this acid-induced pain model may mimic the early-stage responses to tissue injury of knee osteoarthritis.

Original languageEnglish
JournalExperimental Brain Research
Volume236
Issue number2
Pages (from-to)587-598
Number of pages12
ISSN0014-4819
DOIs
Publication statusPublished - Feb 2018

Keywords

  • Journal Article
  • Gender difference
  • Experimental pain
  • Acid-induced pain
  • Osteoarthritis
  • Hyperalgesia
  • Humans
  • Skin/innervation
  • Male
  • Dose-Response Relationship, Drug
  • Young Adult
  • Pain Threshold/drug effects
  • Knee Joint/innervation
  • Time Factors
  • Adult
  • Female
  • Muscle Contraction/drug effects
  • Physical Stimulation
  • Double-Blind Method
  • Pain/chemically induced
  • Functional Laterality/physiology
  • Sex Characteristics
  • Cross-Over Studies
  • Analysis of Variance
  • Acids/adverse effects
  • Hyperalgesia/chemically induced
  • Pain Measurement
  • Hydrogen-Ion Concentration

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