Activation of human alloreactive cytotoxic precursor T lymphocytes

H E Johnsen, M Madsen, J Mossin, S E Christiansen, P W Hansen

Research output: Contribution to journalJournal articleResearchpeer-review

2 Citations (Scopus)

Abstract

The requirements for allogeneic T-cell activation have been studied in experiments with T and/or B cells as stimulator. Although target determinants (TDs, defined by CTL effectors in CML) are present on B and T cells used as target cells, this study indicates that TDs are functionally different when expressed on B and T cells used as stimulator cells, as only B cells can activate CTL precursors. Further, the study confirms that inducing TDs and strong lymphocyte-activating determinants (LADs, defined by proliferation in MLC) can be distinct structures found on two different stimulator B cells. The study suggests that binding of cytotoxic precursor T cells to TDs per se does not allow any detectable activation or start of proliferation and differentiation but requires another function of the stimulator cells in the non-T-cell compartment. The nature of this function is unknown, but it is the background for the first signal received by the TD-specific clones of CTL precursors, resulting in the expression of growth receptors for T-cell growth factor or interleukin 2 which is the second signal necessary for clonal expansion and differentiation.

Original languageEnglish
JournalHuman Immunology
Volume5
Issue number1
Pages (from-to)73-82
Number of pages10
ISSN0198-8859
Publication statusPublished - Aug 1982
Externally publishedYes

Keywords

  • B-Lymphocytes
  • Cytotoxicity, Immunologic
  • Epitopes
  • Humans
  • Lymphocyte Activation
  • T-Lymphocytes

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