Abstract
The requirements for allogeneic T-cell activation have been studied in experiments with T and/or B cells as stimulator. Although target determinants (TDs, defined by CTL effectors in CML) are present on B and T cells used as target cells, this study indicates that TDs are functionally different when expressed on B and T cells used as stimulator cells, as only B cells can activate CTL precursors. Further, the study confirms that inducing TDs and strong lymphocyte-activating determinants (LADs, defined by proliferation in MLC) can be distinct structures found on two different stimulator B cells. The study suggests that binding of cytotoxic precursor T cells to TDs per se does not allow any detectable activation or start of proliferation and differentiation but requires another function of the stimulator cells in the non-T-cell compartment. The nature of this function is unknown, but it is the background for the first signal received by the TD-specific clones of CTL precursors, resulting in the expression of growth receptors for T-cell growth factor or interleukin 2 which is the second signal necessary for clonal expansion and differentiation.
Original language | English |
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Journal | Human Immunology |
Volume | 5 |
Issue number | 1 |
Pages (from-to) | 73-82 |
Number of pages | 10 |
ISSN | 0198-8859 |
Publication status | Published - Aug 1982 |
Externally published | Yes |
Keywords
- B-Lymphocytes
- Cytotoxicity, Immunologic
- Epitopes
- Humans
- Lymphocyte Activation
- T-Lymphocytes