Abstract
The content of arachidonic acid in adipose tissue is positively associated with the risk of myocardial infarction, whereas the content of eicosapentaenoic acid in adipose tissue has been reported to be negatively associated with the risk of myocardial infarction. Both arachidonic acid and eicosapentaenoic acid are substrates for the synthesis of pro-inflammatory leukotrienes and leukotrienes derived from eicosapentaenoic acid are generally much less potent. In this study we hypothesized that a high content of arachidonic acid in adipose tissue would reflect a high formation of arachidonic acid derived leukotrienes and a high expression of 5-lipoxygenase in atherosclerotic plaques. Likewise, we hypothesized that a high content of eicosapentaenoic acid in adipose tissue would reflect a low formation of arachidonic acid derived leukotrienes and a low expression of 5-lipoxygenase in plaques.
| Original language | English |
|---|---|
| Journal | Lipids in Health and Disease |
| Volume | 12 |
| Pages (from-to) | 7 |
| ISSN | 1476-511X |
| DOIs | |
| Publication status | Published - 2013 |
Keywords
- Adipose Tissue
- Aged
- Aged, 80 and over
- Arachidonate 5-Lipoxygenase
- Arachidonic Acid
- Cross-Sectional Studies
- Eicosapentaenoic Acid
- Female
- Femoral Artery
- Gene Expression
- Humans
- Leukotriene B4
- Leukotrienes
- Male
- Middle Aged
- Plaque, Atherosclerotic
- Thrombectomy