Advances in linking polyketides and non-ribosomal peptides to their biosynthetic gene clusters in Fusarium

Mikkel Rank Nielsen, Teis Esben Sondergaard, Henriette Giese, Jens Laurids Sørensen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

The eukaryotic ascomycete genus Fusarium comprises many species capable of producing secondary metabolites important for agriculture, health, and biotechnology. Filamentous fungi share common physiological features, but even within Fusarium, there are significant differences that affect the success of biotechnological methods used to unravel biosynthetic pathways. The aim of this review is to describe the different methods that have successfully been used throughout the genus Fusarium to identify the products of novel biosynthetic pathways. The results are presented in tables to give the reader an overview and thereby enable the selection of the most appropriate method to the problem, regarding both species and target products. Significant work has gone into characterization of the underlying molecular genetics of secondary metabolites, but still, the products of only 25–30% of predicted gene clusters have been identified. In this review, we highlight existing knowledge and encourage the development of new techniques and strategies to provide access to the many unknown polyketide and non-ribosomal peptide products that await discovery in Fusarium.

Original languageEnglish
JournalCurrent Genetics
Volume65
Issue number6
Pages (from-to)1263-1280
Number of pages18
ISSN0172-8083
DOIs
Publication statusPublished - 1 Dec 2019

Keywords

  • Fusarium
  • Gene cluster
  • Natural products
  • NRPS
  • PKS
  • Secondary metabolites

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